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A kind of polyvinyl alcohol hydrogel and its preparation method and application

A technology of polyvinyl alcohol and hydrogel, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of non-degradable polymers and high cytotoxicity, and achieve improved The effect of drug availability

Active Publication Date: 2021-07-20
GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure polyethyleneimine still has many defects, such as relatively high cytotoxicity, non-degradable polymer, etc.

Method used

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  • A kind of polyvinyl alcohol hydrogel and its preparation method and application
  • A kind of polyvinyl alcohol hydrogel and its preparation method and application
  • A kind of polyvinyl alcohol hydrogel and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A preparation method of polyvinyl alcohol hydrogel, comprising the steps of:

[0038] (1) Prepare polyvinyl alcohol aqueous solution: add 10g polyvinyl alcohol into 100mL deionized water, stir until dissolved at 90°C to obtain polyvinyl alcohol aqueous solution, save it for later use;

[0039] (2) Preparation of loaded oridin / sodium alginate microsphere complex: mix 1mL Tween 80 and 100mL olive oil, stir at room temperature at 800r / min for 1h, add 20mL sodium alginate aqueous solution with a mass concentration of 2% dropwise into the olive oil, continue to stir at room temperature for 1 hour, and finally add calcium chloride solution with a mass concentration of 2.5% and 50 mg oridin and stir overnight; the solution is washed three times by centrifugation with isopropanol and deionized water at a centrifugal speed of 10,000 r / min. Centrifuge for 15 minutes each time, and finally freeze-dry at -60°C for 24 hours to obtain the loaded oridin / sodium alginate microsphere com...

Embodiment 2

[0049] A preparation method of polyvinyl alcohol hydrogel material, comprising the steps of:

[0050] (1) Prepare polyvinyl alcohol aqueous solution: add 15g polyvinyl alcohol into 100mL deionized water, stir until dissolved at 90°C to obtain polyvinyl alcohol aqueous solution, save it for later use;

[0051] (2) Preparation of loaded oridin / sodium alginate microsphere complex: mix 1mL Tween 80 and 100mL olive oil, stir at room temperature at 800r / min for 1h, add 20mL sodium alginate aqueous solution with a mass concentration of 2% dropwise into the olive oil, continue to stir at room temperature for 1 hour, and finally add calcium chloride solution with a mass concentration of 2.5% and 100 mg oridin and stir overnight; the solution is washed three times by centrifugation with isopropanol and deionized water, and the centrifugal speed is 10000r / min. Centrifuge for 15 minutes each time, and finally freeze-dry at -60°C for 24 hours to obtain the loaded oridin / sodium alginate mic...

Embodiment 3

[0057] A preparation method of polyvinyl alcohol hydrogel material, comprising the steps of:

[0058] (1) Prepare polyvinyl alcohol aqueous solution: add 20g polyvinyl alcohol into 100mL deionized water, stir until dissolved at 90°C to obtain polyvinyl alcohol aqueous solution, save it for later use;

[0059] (2) Preparation of loaded oridin / sodium alginate microsphere complex: mix 1mL Tween 80 and 100mL olive oil, stir at room temperature at 800r / min for 1h, add 20mL sodium alginate aqueous solution with a mass concentration of 3% dropwise into the olive oil, continue to stir at room temperature for 1 hour, and finally add calcium chloride solution with a mass concentration of 5% and 100 mg oridin and stir overnight; the solution is washed three times by centrifugation with isopropanol and deionized water, and the centrifugal speed is 10000r / min. Centrifuge for 15 minutes each time, and finally freeze-dry at -60°C for 24 hours to obtain the loaded oridin / sodium alginate micro...

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Abstract

The invention relates to a polyvinyl alcohol hydrogel and a preparation method and application thereof, belonging to the technical field of polymer hydrogels. In the present invention, oridin is added dropwise to sodium alginate microsphere solution, and after treatment, oridin / sodium alginate microsphere complex is obtained; polyethyleneimine derivative carrier is prepared by EDC / NHS activation reaction for loading micro RNA; finally, the oridin / sodium alginate microsphere complex, microRNA / polyethyleneimine derivative carrier and polyvinyl alcohol solution are uniformly mixed, and then freeze-thawed repeatedly to form a hydrogel material. The hydrogel loaded with oridin / sodium alginate microsphere complex and microRNA / polyethyleneimine derivative carrier of the present invention has the functions of drug slow release and microRNA regulation, and can improve the drug availability of oridinin , and has the effect of gene therapy, and can be applied in skin wound dressings.

Description

technical field [0001] The invention relates to a polyvinyl alcohol hydrogel and a preparation method and application thereof, belonging to the technical field of polymer hydrogels. Background technique [0002] The skin is located on the surface of the human body and is one of the largest and most important organs in the human body. Since the skin is exposed to the external environment for a long time, it may be damaged at all times. When the trauma is very serious, such as burns, severe frostbite, mechanical trauma, ulcers caused by chronic diseases, etc., it not only brings pain to the patient, but even leads to death. Compared with traditional dressings, it is necessary to develop new dressings that can promote healing. [0003] Polyvinyl alcohol (PVA) is a long-chain water-soluble polymer obtained by hydrolysis of polyvinyl ester. It is non-toxic, tasteless, non-irritating to the skin, does not cause skin allergies, and has good film-forming properties and adhesive pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00A61K9/06A61K47/32A61K47/36A61K47/34A61K31/352A61K31/7105A61P17/02
CPCA61K9/06A61K31/352A61K31/7105A61K47/32A61K47/34A61K47/36A61L26/0014A61L26/0019A61L26/0023A61L26/0066A61L26/008A61L26/0085A61L2300/216A61L2300/258A61L2300/412A61L2300/602A61P17/02C08L29/04C08L5/04C08L79/02A61K2300/00
Inventor 刘玉蓝咏马春铭陈泰瀛
Owner GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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