39results about How to "Adjustable particle size" patented technology

The invention discloses a method for preparing therapeutic substance-loaded microcapsules. The method applies the high-voltage electrostatic spray principle and comprises the steps of leading therapeutic substance-loaded charged polymer solution to instantaneously form ultrafine gel particles under the high-voltage electrostatic action, leading a mist of the particles to be received by polymer solution charged with opposite charges, leading a surface layer of the gel particles to be wrapped by a polymer gel shell layer of the opposite charges, forming structures of capsule cores and capsule walls, further filtering by a microporous membrane, and obtaining the therapeutic substance-loaded microcapsules. Microstructures and scale of the capsule cores and the capsule walls can be precisely controlled through voltage, solution concentration and distance from a jet orifice to receiving solution, and therapeutic substances are bound by the capsule cores and the capsule walls, thereby forming controlled release and improving therapeutic efficacy. The method has the advantages of simple and feasible process and good repeatability, the whole process of the preparation process is clean and pollution-free, the provided in-situ therapeutic substance-loaded microcapsules do not need the complex post-processing, the particle size is controllable, and the release rate of the therapeutic substances is convenient to control, thereby having good application prospect.

The invention relates to a silicon dioxide-based anti-adhesion agent used for a polyolefin thin film and a preparation method thereof. The silicon dioxide-based anti-adhesion agent is suitable for plastic thin film production enterprises. The preparation method includes the following steps of: 1) preparing silicon dioxide sol from tetraethyl orthosilicate under alkaline conditions; 2) adding a surfactant and a proper oil phase organic substance, and stirring the mixture to prepare a micelle with silicon dioxide as a shell layer; 3) adding trimethoxy silane containing an R group and a catalyst to the micelle with the silicon dioxide as the shell layer, and stirring the mixture to prepare silicon dioxide-based microspheres at a certain temperature, wherein the surfaces of silicon dioxide are modified by silane; and 4) drying the microspheres to remove the oil phase to obtain silicon dioxide hollow microspheres. The silicon dioxide-based anti-adhesion agent is a compound having definite structural and molecular formulas and molecular weight, but is a hollow microsphere which has a hierarchical pore structure and is based on silicon dioxide. The anti-adhesion agent can reinforce a plastic thin film and improves creep resistance, wherein a large quantity of micro projections and gaps are formed on the surface of the thin film, thereby increasing roughness of the thin film, reducing friction coefficient and preventing adhesion of the thin films.

The invention relates to a bionic magnetosome loaded with siRNA and a preparation method of the magnetosome, and belongs to the field of chemistry and biomedicine. According to the bionic magnetosome, water-soluble MNC serves as the kernel and is wrapped by a white cell membrane, and siRNA is loaded between the MNC and the white cell membrane; antibodies or peptides with modifying groups can be coupled outside the white cell membrane of the bionic magnetosome in a covalence mode. By preparing MNC, M and MNC:siRNA and mixing an MNC:siRNA solution, an M solution and a buffer solution, the bionic magnetosome is obtained; the white cell membrane of the bionic magnetosome is modified by the peptides or antibodies through the modifying groups, and the bionic magnetosome coupled with the antibodies or peptides is obtained. The MNC in the bionic magnetosome has positive charges, can adsorb siRNA and is wrapped by M for bionics, a focus is reached efficiently and rapidly, and meanwhile immune elimination of organisms is avoided.