Magnesium-based composite material as well as preparation method and application thereof

A composite material, magnesium-based matrix technology, applied in the fields of biomedical engineering and biomedical materials, can solve the problems of difficult to meet precision medicine, lack of tissue regeneration, and difficult to solve the problem of continuous and stable release of loaded drugs.

Active Publication Date: 2021-10-26
INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing magnesium-based implants are mostly used for internal bone fixation. Although they meet the requirements of light weight and degradability, they still lack the ability to effectively induce tissue regeneration, and it is difficult to meet the needs of precision medicine.
[0004] In order to enable magnesium and its alloy implants to obtain the ability to induce tissue regeneration, researchers have tried to load magnesium and its alloys with drugs to make them have a drug-controlled release function, but the existing technology is difficult to solve the problem of sustained stability of the loaded drugs The puzzle of release

Method used

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  • Magnesium-based composite material as well as preparation method and application thereof
  • Magnesium-based composite material as well as preparation method and application thereof
  • Magnesium-based composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0123] In this embodiment, a magnesium-based composite material is prepared, and the specific process is as follows:

[0124] A1. Use 800-mesh SiC sandpaper to polish the magnesium-based material (magnesium content > 99%), then rinse with deionized water for 2 minutes, dehydrate with ethanol for 4 minutes, and then immediately dry in air;

[0125] A2. Under mechanical stirring, mix 18g Na 3 PO 4 12H 2 O (about 47mM) and 3g Ca(OH) 2 Dissolve (approximately 40.5mM) in 1L aqueous solution, and mechanically stir for 6 minutes to obtain an electrolyte;

[0126] A3. Using the constant current mode, the magnesium-based material obtained in step S1 is treated with the plasma electrolytic oxidation method; specifically, in the plasma electrolytic oxidation treatment, the current frequency is 2000 Hz, the duty cycle is 20%, the positive voltage is 500 V, and the temperature is 80°C, under stirring, first with 0.03A / cm 2 The current density was treated for 25s, and then 0.8A / cm 2 T...

Embodiment 2

[0136] In this embodiment, a magnesium-based composite material is prepared, and the specific process is as follows:

[0137] A1. Use 280-mesh SiC sandpaper to polish the magnesium-based material (magnesium content > 99%), then rinse with deionized water for 2 minutes, dehydrate with ethanol for 4 minutes, and then immediately dry in air;

[0138] A2. Under mechanical stirring, 10g Na 3 PO 4 12H 2 O (about 26mM) and 1g Ca(OH) 2 (about 13.5mM) was dissolved in 1L aqueous solution, and mechanically stirred for 3 minutes to obtain an electrolyte;

[0139] A3. Using the constant current mode, the magnesium-based material obtained in the plasma electrolytic oxidation treatment step S1; specifically, in the plasma electrolytic oxidation treatment, the current frequency is 2000Hz, the duty cycle is 20%, the positive voltage is 500V, and the temperature is 60°C , under stirring, first at 0.01A / cm 2 The current density was treated for 60s, and then 1.5A / cm 2 The current density w...

Embodiment 3

[0149] In this embodiment, a magnesium-based composite material is prepared, and the specific process is as follows:

[0150] A1. Use 1000-mesh SiC sandpaper to polish the magnesium-based material (magnesium content > 99%), then rinse with deionized water for 2 minutes, dehydrate with ethanol for 4 minutes, and then immediately dry in air;

[0151] A2. Under mechanical stirring, mix 15g Na 3 PO 4 12H 2 O (about 39mM) and 2g Ca(OH) 2 (about 27mM) was dissolved in 1L aqueous solution, and magnetically stirred for 5 minutes to obtain an electrolyte;

[0152] A3. Using the constant current mode, the magnesium-based material obtained in the plasma electrolytic oxidation treatment step S1; specifically, in the plasma electrolytic oxidation treatment, the current frequency is 2000Hz, the duty cycle is 20%, the positive voltage is 500V, and the temperature is 75°C , under stirring, first at 0.02A / cm 2 The current density was treated for 30s, and then 1A / cm 2 The current density ...

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Abstract

The invention discloses a magnesium-based composite material and a preparation method and application thereof, and belongs to the technical field of biomedical engineering and biomedical materials. The magnesium-based composite material comprises a magnesium-based matrix, and the surface of the magnesium-based matrix is provided with a pore structure; drug-loading particles are loaded on the surface of the magnesium-based matrix, and the skeleton of the drug-loading particles is meso-porous silicon-based particles; mesopores of the meso-porous silicon-based particles contain a drug; the surface of the drug is coated with a first sustained-release film; and a second sustained-release film is coated on the surfaces of the magnesium-based matrix and the drug-loading particles. The magnesium-based composite material provided by the invention can meet the requirements of stable release of the loaded drug in vivo and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering and biomedical materials, and in particular relates to a magnesium-based composite material and its preparation method and application. Background technique [0002] Ideal bone repair products should meet the requirements of light weight, precise mechanical matching, high bioactivity, inducible autologous tissue and blood vessel remodeling, and controllable degradation. [0003] Magnesium and its alloys are clinically recognized as degradable and biocompatible metal materials, which have the advantages of low density, can promote osteogenesis, and induce bone ingrowth. However, the application of magnesium-based implants at this stage is mainly based on Materials for internal bone fixation are mainly used, and specific commercialized products include magnesium alloy internal bone fixation screws produced by Syntellix in Germany and U&i in South Korea; degradable magnesium internal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/56A61L17/00A61L17/14A61L27/02A61L27/04A61L27/32A61L27/34A61L27/50A61L31/02A61L31/08A61L31/10A61L31/14A61L31/16C25D11/30
CPCA61L27/54A61L27/56A61L27/50A61L27/047A61L27/32A61L27/025A61L27/34A61L17/145A61L17/005A61L17/00A61L31/022A61L31/028A61L31/086A61L31/10A61L31/146A61L31/16A61L31/14C25D11/30C25D11/026A61L2430/02A61L2300/602A61L2300/412A61L2300/216A61L2300/252C08L71/02C08L67/04
Inventor 许为康
Owner INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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