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Adriamycin nanoparticle with particle size controllable and preparation method thereof

A nanoparticle and doxorubicin technology, which is applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problem that the size and shape of nanoparticles are difficult to control and the stability of the human circulatory system is not good. , Difficult to reach the lesions and other problems, to achieve good biological safety and histocompatibility, improve anti-tumor activity, and enhance the effect of treatment

Inactive Publication Date: 2017-03-22
INST OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCI
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  • Abstract
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  • Application Information

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Problems solved by technology

[0003] However, the synthesis and application of nanoparticles still face many problems. For example, the size and shape of nanoparticles are not easy to control, low biological safety and strong immunogenicity, and the stability of the human circulatory system is not good, so it is difficult to reach the lesion smoothly. Not easy to degrade and other issues

Method used

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  • Adriamycin nanoparticle with particle size controllable and preparation method thereof
  • Adriamycin nanoparticle with particle size controllable and preparation method thereof
  • Adriamycin nanoparticle with particle size controllable and preparation method thereof

Examples

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Embodiment Construction

[0031] The present invention is described in detail below by embodiment, so that the characteristics and advantages of the present invention are clearer. However, it should be pointed out that the examples are used to understand the concept of the present invention, and the scope of the present invention is not limited only to the examples listed herein.

[0032] Unless otherwise specified, the raw materials used in the examples are all commercially available products, and the operations used are all conventional operations in the art.

[0033] Preparation of Adriamycin Nanoparticles with Controllable Particle Size

[0034] 1. Preparation of poly(isobutylene-alt-maleic anhydride) modified β-cyclodextrin (p(IB-alt-MAnh)-CD)

[0035] (1) Dissolve poly(isobutylene-alt-maleic anhydride) (p(IB-alt-MAnh), Mn(0.5K-1K) in DMSO at a concentration of 5-15 mg / ml;

[0036] (2) Add 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride mol ratio 2-3 times to the repeated chain number o...

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Abstract

The invention provides an adriamycin nanoparticle with the particle size controllable. The adriamycin nanoparticle is formed by taking polyethylene glycol vitamin E succinate (TPGS) as a core and wrapping the core with polyethylene glycol-adriamycin and poly(isobutene-alt-maleic anhydride)-modified beta-cyclodextrin through self-assembly. The invention further provides a preparation method of the adriamycin nanoparticle. Compared with a traditional nanoparticle prepared through a chemical bond forming and rupturing method, the adriamycin nanoparticle is controllable in particle size, simple in preparation process, mild in reaction condition and capable of easily obtaining the raw materials and has the good biological safety and tissue compatibility.

Description

technical field [0001] The invention relates to the field of preparation and biological application of nanoparticles, in particular to a doxorubicin nanoparticle with controllable particle size and a preparation method thereof. Background technique [0002] For a long time, researchers have been working on a method to prepare organic polymer nanoparticles with controllable particle size. Over the past few decades, a great deal of research has been done on the biological and pharmaceutical applications of nanoparticles, and several different types of nanoparticles have been used in different fields and to varying degrees. For example, gold nanoparticles and superparamagnetic nanoparticles modified with corresponding targeting molecules can be used to display tumor cells in vivo; drug molecules can be modified on nanoparticles, and antitumor drugs can be transported to the lesion site through a certain transport mechanism. Slow release, which can greatly reduce the side effec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K31/704A61K31/337A61K47/60A61K47/22A61K47/40A61P35/00
CPCA61K9/5146A61K9/5161A61K31/337A61K31/704A61K2300/00
Inventor 陈俊谢进胡毅
Owner INST OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCI
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