15 results about "Propargyl alcohol" patented technology

The invention relates to a process for the production of an organic layer comprising regions with different electronic properties. The process is based on the use of dihydroanthracene, dihydrobenzene, benzol or fluorene precursors functionalised with at least one substituted propargyl alcohol. By subjecting these precursors to a reduction / re-aromatisation reaction and / or to a retro-Favorskii reaction one obtains small organic molecules or polymers having different electronic properties, due to the specific chemical composition generated by the different chemical reactions in which the precursors are involved. Therefore, starting from the same precursor and subjecting it alternatively to the two specified reactions, one obtains products with different electronic properties. i.e. molecules characterised by high energy levels of the highest occupied molecular orbital (HOMO), which have at least one aromatic ring substituted with at least one ethynyl group, and molecules characterised by lower energy levels of the lowest unoccupied molecular orbital (LUMO), which have at least one carbonyl functionality, preferably at least one quinone ring or at least one phenyl with at least one carbonyl functionality. The reactions are carried out in such a way that the final products are incorporated into a single organic layer.

The invention discloses a method for synthesizing chiral morpholine from propargyl alcohol ester. Chiral morpholine is an important drug molecular skeleton and is widely applied to the aspects of analgesia, anesthesia, tumor resistance, heart treatment and the like as a drug active ingredient, but an efficient synthesis method is lacked. According to the method disclosed by the invention, under the regulation and control of arylboronic acid and a specific chiral ligand, propargyl alcohol ester and an affinity reagent react to obtain optically pure (87-97% ee) morpholine. The method has the characteristics that the catalyst and the ligand are wide in source, and the substrate is cheap and easy to obtain; the chiral morpholine has excellent enantioselectivity and good functional group compatibility, can be suitable for structural modification of bioactive molecules and intermediates, and is a simple and efficient asymmetric catalysis strategy for synthesizing chiral morpholine.

The invention relates to the technical field of organic chemical synthesis, in particular to a carbazole axially chiral tetra-substituted allene derivative which is a compound containing a structure shown in the formula (III), R1 is connected with a benzene ring, and R1, R2 and R3 are independently selected from H, alkyl, halogen, silicon, alkenyl, alkynyl, aryl, acyl, sulfonyl, heteroaryl and benzyl. Compared with the prior art, the carbazole axially chiral tetra-substituted allene derivative is obtained by combining the carbazole compound and the propargyl alcohol compound in an addition manner, and the carbazole axially chiral tetra-substituted allene derivative has an allene skeleton and a carbazole active fragment at the same time; the compound can be used as a potential skeleton for developing novel antibacterial and antitumor drugs.

This invention relates to the field of lithium battery electrolyte technology, specifically a method for synthesizing tripropynyl phosphate, comprising the following steps: 1) In a dry reaction vessel, an organic solvent is added, and phosphorus oxychloride is dissolved in the organic solvent, and stored under an inert atmosphere at low temperature; 2) A mixture of propynyl alcohol and triethylamine is slowly added dropwise, and the reaction is continuously stirred while maintaining a low temperature; 3) The mixture is slowly added dropwise, and the reaction is stirred after the temperature is raised to room temperature; 4) The mixture is slowly added to the reaction vessel, and the reaction is stirred after the temperature is raised to room temperature; 5) The triethylamine hydrochloride is removed by filtration, and the filtrate is distilled under reduced pressure to obtain a crude product, which is then purified by reduced pressure distillation or column chromatography. This invention effectively solves the problems of violent exothermic reactions, numerous side reactions, harsh reaction conditions, and difficulties in post-processing and purification of the product in existing synthesis methods by rationally designing reaction steps and precisely controlling reaction conditions and molar ratios.

The application discloses a lubricating coating for high-temperature fasteners and a preparation method and application thereof. The lubricating coating is prepared by using inorganic phosphate as a binder, nano boron nitride, silver powder, molybdenum disulfide and tungsten disulfide as composite lubricants, antimony trioxide as an antioxidant, nano silicon dioxide as a phosphate binder reinforcing agent, water and anhydrous ethanol as a dispersion medium, and propargyl alcohol as a corrosion inhibitor. The coating is immersed or sprayed on the fastener, and a coating is formed after a certain curing condition. The coating has good adhesion, flexibility and impact resistance, and has no corrosion defects such as pitting, cracking and bubbling after an acetate salt spray test (AASS) for 240 hours. According to the locking torque test in accordance with HB 7687-2001, the locking torque requirement is met after 15 cycles at room temperature and 5 times of warm loading and then air cooling to room temperature. The application has a good application prospect in the field of high-temperature fastener coatings.

This application provides a method for preparing methylcarboxylic acid-2-propynyl ester, comprising the following steps: (1) mixing dimethyl carbonate and propargyl alcohol, adding a first alkaline catalyst, stirring and heating to a temperature of 90-105°C, and distilling out methanol by reactive distillation to obtain a first component; (2) performing solid-liquid separation on the first component to obtain a first liquid, and performing vacuum distillation on the first liquid to remove propargyl alcohol and dimethyl carbonate to obtain methylcarboxylic acid-2-propynyl ester and residue; (3) performing vacuum distillation on the residue, replenishing dimethyl carbonate and the second alkaline catalyst with the distillate for reaction, and reusing the reaction liquid in step (2). This application uses the transesterification reaction of propargyl alcohol and dimethyl carbonate to synthesize methylcarboxylic acid-2-propynyl ester, which has high safety, low overall reaction temperature, fewer by-products and waste, and high yield.

The invention discloses a coupling reaction of palladium-catalyzed secondary propargyl alcohol benzoate and sulfonamide to realize high-selectivity synthesis of 2-amido-substituted conjugated diene, and the method is suitable for coupling of a series of functionalized propargyl alcohol benzoate and sulfonamide. In addition, later-stage functional modification of complex small molecule drugs can be achieved through the method, a new method is provided for synthesis of sulfonamide compounds containing conjugated diene structures, and the method has important application prospects.

The invention belongs to the technical field of chemical reaction prediction, and discloses an analysis method for a tandem cyclization reaction mechanism of double-metal system catalyzed pyridyl homopropargyl alcohol and propargyl alcohol. The analysis method comprises the following steps: (1) respectively constructing calculation models of an Au (I) catalyst, a Cu (II) catalyst and a substrate pyridyl high-propargyl alcohol structure and a substrate pyridyl high-propargyl alcohol structure; (2) designing a reaction path under an Au (I) catalyst and a Cu (II) catalyst, and constructing an intermediate and a transition state; (3) screening a catalyst for catalytic synthesis of 2, 3-dihydrofuran and polycyclic dihydrobenzofuran; and (4) analyzing the reaction mechanism and path under the Au (I) catalyst and the Cu (II) catalyst. According to the invention, a highly coordinated bimetallic catalytic mechanism is emphasized by applying a density functional theory, and a valuable insight is provided for understanding and designing the bimetallic catalytic mechanism. The result obtained by the analysis method is very consistent with the experimental result, and the calculation result is accurate and reliable.

The invention discloses a copper monatomic catalyst with stable N-heterocyclic carbene as well as a preparation method and application of the copper monatomic catalyst with stable N-heterocyclic carbene. According to the method, construction of a porous organic polymer carrier and anchoring of metal monatomic active sites are innovatively combined, and the copper monatomic catalyst with stable N-heterocyclic carbene is prepared through a one-pot mechanical grinding strategy. A triazine compound, a nitrogen-containing heterocyclic compound, a copper salt and alkali directly react under the assistance of no solvent or a trace amount of solvent, and the catalyst POP-n-NHC-CuX (n = I-IV, X = Cl, Br or I) is obtained through in-situ synchronous synthesis. In the obtained catalyst, copper atoms are stably anchored on a polymer skeleton in a coordination bond form through an NHC ligand to form atomic-scale dispersed active sites. The catalyst can efficiently catalyze the conversion reaction of CO2 and propargyl alcohol and derivatives thereof under mild conditions, is suitable for synthesizing various high value-added chemicals including alpha-alkylene cyclic carbonate, oxazolidinone and beta-oxypropyl carbamate, and shows excellent catalytic cycle stability and substrate universality.

The invention discloses a method for synthesizing a non-cyclic and non-terminal vicinal diol derivative based on propargyl alcohol ester. Through a coupling strategy that propargyl alcohol ester and an exogenous nucleophilic reagent are catalyzed by transition metal (palladium), construction of a bimolecular exogenous nucleophilic group substituted allyl skeleton is realized. The strategy breaks through the dilemma that alkenylation products are limited to construction of cyclic molecules at the present stage and the tail ends of the alkenylation products are limited, and a reform synthesis scheme is provided for selective conversion of propargyl alcohol ester catalyzed by transition metal. The selected catalyst and ligand are wide in source, and the substrate is cheap and easy to obtain; the method provided by the invention has the advantages of high selectivity, excellent stereoselectivity and good functional group compatibility, can be suitable for structural modification of bioactive molecules and intermediates, is a simple and efficient asymmetric catalysis strategy for synthesizing non-cyclic and non-terminal vicinal diol derivatives, and has a good application prospect.

This invention discloses a method for synthesizing α-alkylmethylene cyclic carbonates, which utilizes a porous organic polymer silver-based nanocatalyst to catalyze a carboxylation-cyclization reaction between carbon dioxide and propargyl alcohol compounds to obtain α-alkylmethylene cyclic carbonates; the general structural formula of the porous organic polymer silver-based nanocatalyst is: [Ag-M-(N)4] n M is selected from porphyrin compounds; the structural formula of M is as follows: where R is independently selected from hydrogen atom or nitro group; N is selected from one of N1-N4 compounds: Compared with existing catalysts, the porous organic polymer silver-based nanocatalyst of the present invention is green and pollution-free, has good stability, has a small silver nanoparticle size, and requires a small amount of catalyst for carboxylation and cyclization reactions, and the reaction conditions are relatively mild.

The application provides a porous organometallic palladium polymer applied to selective hydrogenation of terminal alkynyl propanol, a preparation method and application thereof. The porous organometallic palladium polymer comprises a reaction product of a palladium-based metal organic compound, a comonomer and a crosslinking agent, and the palladium-based metal organic compound is selected from one of bisbenzimidazole nitrogen heterocyclic carbene palladium chloride, bis-triphenylphosphine palladium chloride or tetra-triphenylphosphine palladium. The porous organometallic palladium polymer of the application has the advantages of homogeneous catalysis and heterogeneous catalysis as a catalyst, has the advantages of high catalytic efficiency, good selectivity, wide applicability, easy recovery, greenness, economy and the like, and can realize a series of hydrogenation reactions under ultra-low catalytic amount and mild conditions.

The application discloses a synthesis method of unsaturated ketone, comprising the following steps: reacting alkoxy olefin and propargyl alcohol in a tubular reactor in the presence of an acidic solid catalyst to generate unsaturated ketone; the tubular reactor comprises N reaction tube sections connected in series, and the reactant material flows through the first reaction tube section to the Nth reaction tube section in sequence; each reaction tube section is independently provided with an acidic solid catalyst and comprises a circulation tube section for circulating part of the reactant material from a discharge port of the tube section to a feed port of the tube section; the amount of the acidic solid catalyst arranged in each reaction tube section is sequentially increased from the first reaction tube section to the Nth reaction tube section; the circulation ratio of each reaction tube section is controlled to make the reactant material in a turbulent flow state, and the circulation ratio of the first reaction tube section is 7-20; the method can realize the preparation of unsaturated ketone with high selectivity and high yield under the premise of no solvent and common acidic solid catalyst, the operation process is easy to realize, and the method is suitable for industrial application.

The present application relates to the technical field of analytical detection, and particularly relates to a method for determining water content in a propynol system sample by adding an organic solvent, comprising the following steps: (1) taking a to-be-detected layered sample containing water, n-propyl acetate and propynol in a propynol production process; (2) adding an alcohol organic solvent to the to-be-detected layered sample, stirring uniformly, and changing the sample from a water-oil layered state to a uniform clear solution; (3) determining water content in the uniform clear solution obtained in step (2) by using a Karl Fischer method. The present application has the advantages that the method eliminates the interference of water-oil layering on water content determination, improves the accuracy and repeatability of determination, and is suitable for propynol production process control.