43 results about "Propargyl alcohol" patented technology

The invention relates to a process for the production of an organic layer comprising regions with different electronic properties. The process is based on the use of dihydroanthracene, dihydrobenzene, benzol or fluorene precursors functionalised with at least one substituted propargyl alcohol. By subjecting these precursors to a reduction / re-aromatisation reaction and / or to a retro-Favorskii reaction one obtains small organic molecules or polymers having different electronic properties, due to the specific chemical composition generated by the different chemical reactions in which the precursors are involved. Therefore, starting from the same precursor and subjecting it alternatively to the two specified reactions, one obtains products with different electronic properties. i.e. molecules characterised by high energy levels of the highest occupied molecular orbital (HOMO), which have at least one aromatic ring substituted with at least one ethynyl group, and molecules characterised by lower energy levels of the lowest unoccupied molecular orbital (LUMO), which have at least one carbonyl functionality, preferably at least one quinone ring or at least one phenyl with at least one carbonyl functionality. The reactions are carried out in such a way that the final products are incorporated into a single organic layer.

The invention discloses a preparation method of a cyanoborate lithium salt derivative, which comprises the following steps: 1, mixing an alcohol compound, a lithium source compound, a boron source compound and trimethylsilyl cyanide in a polar organic solvent, and filtering after complete reaction to obtain a cyanoborate crude product filtrate; the alcohol compound is selected from one of 2, 2, 2-trifluoroethanol, 2, 2-difluoroethanol, 2-fluoroethanol, 3-hydroxypropionitrile, allyl alcohol and propargyl alcohol; the lithium source compound is selected from one of lithium carbonate and lithium hydroxide; the boron source compound is selected from one of boric acid, diboron trioxide and boron tribromide; the reaction temperature is controlled to be 0-120 DEG C; and 2, adding an inert organic solvent into the cyanoborate crude product filtrate for crystallization, and performing vacuum drying to obtain a finished product of the cyanoborate lithium salt. The method has the advantages of high yield and purity, simple process, convenience in operation and low cost, and is extremely suitable for industrial production.

The present application relates to the technical field of fine chemical product synthesis, and in particular to a synthesis method of 3-chloropropynyl co-production of p-chlorobenzaldehyde, which comprises the following steps: mixing propargyl alcohol, a solvent, an ionic liquid catalyst, a cocatalyst DMF and a polymerization inhibitor p-tert-butyl catechol, heating and slowly adding p-chlorobenzylidene dichloride dropwise into the mixture, collecting the generated 3-chloropropynyl crude product at the tail gas outlet, cooling after the reaction is completed, and sequentially reducing pressure rectification of 3-chloropropynyl, the remaining propargyl alcohol and the solvent, and p-chlorobenzaldehyde product through a rectification tower. The present application solves the problems of using toxic and hazardous chemicals chlorinating agent in the production of existing 3-chloropropynyl, and generating a large amount of toxic waste acid gas or low-value byproducts, and the problem of low utilization rate of chlorine atom in the existing direct hydrolysis method of p-chlorobenzaldehyde, and reduces environmental pollution.

The application discloses a catalytic synthesis method of chiral polysubstituted hydrogenated quinoline compounds, and belongs to the field of organic synthesis. The application comprises the following steps: at 0-40 DEG C, alcohol or halogenated alkane is used as a solvent, a copper metal catalyst and a chiral ligand are added, and reaction is carried out under nitrogen protection for 0.5-2 hours; the temperature is lowered to-60-0 DEG C; then, o-aminophenyl nitrone, propargyl alcohol ester and alkali are sequentially added; and reaction is carried out for 6-48 hours, so as to obtain a chiral polysubstituted hydrogenated quinoline compound shown in formula 1 or 2. The application realizes, for the first time, synthesis of chiral polysubstituted hydrogenated quinoline compounds by using o-aminophenyl nitrone and propargyl alcohol ester as reactants, and by using a cheap copper metal catalyst and a chiral ligand, the method is simple in operation, low in cost, and has excellent enantioselectivity and diastereoselectivity.

The present invention relates to a Zr-based Cr / P-free composition for treating a metal surface, comprising: (A) a source of hexafluorozirconate ions; (B) Zn cations; (C) Mg cations; and (D) at least one corrosion inhibitor selected from the group consisting of a propargyl alcohol alkoxy compound and its derivatives, a thiodiglycol ethoxylate and its derivatives, and combinations thereof; wherein the pH value of the composition is in the range of from 3.5 to 6.5, and the concentration of the component (A) calculated on the basis of Zr element is higher than 5 ppm, based on the total weight of the Zr-based Cr / P-free composition. The present invention also relates to a process for treating a metal surface with the composition, and a substrate containing a metal surface treated by the process.

The invention discloses a preparation method of tris (propargyl) phosphorus oxide, and belongs to the technical field of battery electrolyte additives, and the preparation method specifically comprises the following steps: S1, carrying out low-temperature in-situ Grignard exchange and addition reaction, the method comprises the following steps: carrying out in-situ Grignard exchange and addition reaction on phosphorus trichloride, an alkyl lithium reagent and propargyl alcohol in an organic solvent to generate an intermediate tris (propargyl) phosphorous acid; s2, oxidation reaction: adding an oxidizing agent into the reaction system obtained in the step S1, and carrying out oxidation reaction to obtain tris (propargyl) phosphorus oxide; according to the method, the technical bottleneck of preparing the phosphorus-containing alkyne additive by a traditional fractional step method is broken through, a one-pot low-temperature synchronous dropwise adding in-situ reaction process is initiated, and efficient and high-selectivity synthesis of tris (propargyl) phosphorus oxide is realized.

The invention discloses a method for synthesizing chiral morpholine from propargyl alcohol ester. Chiral morpholine is an important drug molecular skeleton and is widely applied to the aspects of analgesia, anesthesia, tumor resistance, heart treatment and the like as a drug active ingredient, but an efficient synthesis method is lacked. According to the method disclosed by the invention, under the regulation and control of arylboronic acid and a specific chiral ligand, propargyl alcohol ester and an affinity reagent react to obtain optically pure (87-97% ee) morpholine. The method has the characteristics that the catalyst and the ligand are wide in source, and the substrate is cheap and easy to obtain; the chiral morpholine has excellent enantioselectivity and good functional group compatibility, can be suitable for structural modification of bioactive molecules and intermediates, and is a simple and efficient asymmetric catalysis strategy for synthesizing chiral morpholine.

The invention relates to the technical field of organic chemical synthesis, in particular to a carbazole axially chiral tetra-substituted allene derivative which is a compound containing a structure shown in the formula (III), R1 is connected with a benzene ring, and R1, R2 and R3 are independently selected from H, alkyl, halogen, silicon, alkenyl, alkynyl, aryl, acyl, sulfonyl, heteroaryl and benzyl. Compared with the prior art, the carbazole axially chiral tetra-substituted allene derivative is obtained by combining the carbazole compound and the propargyl alcohol compound in an addition manner, and the carbazole axially chiral tetra-substituted allene derivative has an allene skeleton and a carbazole active fragment at the same time; the compound can be used as a potential skeleton for developing novel antibacterial and antitumor drugs.

This invention relates to the field of lithium battery electrolyte technology, specifically a method for synthesizing tripropynyl phosphate, comprising the following steps: 1) In a dry reaction vessel, an organic solvent is added, and phosphorus oxychloride is dissolved in the organic solvent, and stored under an inert atmosphere at low temperature; 2) A mixture of propynyl alcohol and triethylamine is slowly added dropwise, and the reaction is continuously stirred while maintaining a low temperature; 3) The mixture is slowly added dropwise, and the reaction is stirred after the temperature is raised to room temperature; 4) The mixture is slowly added to the reaction vessel, and the reaction is stirred after the temperature is raised to room temperature; 5) The triethylamine hydrochloride is removed by filtration, and the filtrate is distilled under reduced pressure to obtain a crude product, which is then purified by reduced pressure distillation or column chromatography. This invention effectively solves the problems of violent exothermic reactions, numerous side reactions, harsh reaction conditions, and difficulties in post-processing and purification of the product in existing synthesis methods by rationally designing reaction steps and precisely controlling reaction conditions and molar ratios.

This invention relates to the field of organic synthesis technology, and more particularly to a method for preparing sulfone-substituted indene compounds. The method involves mixing a propargyl alcohol compound, a sodium sulfinate compound, an acid promoter, and a solvent, and carrying out a tandem sulfonation-cyclization reaction to obtain the sulfone-substituted indene compound. This method has the advantages of readily available raw materials, no catalyst required, ease of operation, and being green and efficient, showing good prospects for industrial application.

The application discloses a lubricating coating for high-temperature fasteners and a preparation method and application thereof. The lubricating coating is prepared by using inorganic phosphate as a binder, nano boron nitride, silver powder, molybdenum disulfide and tungsten disulfide as composite lubricants, antimony trioxide as an antioxidant, nano silicon dioxide as a phosphate binder reinforcing agent, water and anhydrous ethanol as a dispersion medium, and propargyl alcohol as a corrosion inhibitor. The coating is immersed or sprayed on the fastener, and a coating is formed after a certain curing condition. The coating has good adhesion, flexibility and impact resistance, and has no corrosion defects such as pitting, cracking and bubbling after an acetate salt spray test (AASS) for 240 hours. According to the locking torque test in accordance with HB 7687-2001, the locking torque requirement is met after 15 cycles at room temperature and 5 times of warm loading and then air cooling to room temperature. The application has a good application prospect in the field of high-temperature fastener coatings.

The application discloses a kind of water-based polyurethane coating and preparation method thereof, it is related to paint technical field.The water-based polyurethane coating prepared in the application includes component A and component B, component A includes modified polyurethane dispersion, wetting agent, defoaming agent, thickening agent, stabilizer;Component B includes modified silica, dispersant, wetting agent;The modified polyurethane dispersion is prepared by isofuroxone diisocyanate, phosphorus-containing dihydric alcohol, propargyl alcohol, dimethylol butyric acid reaction;The modified silica is the silica that is wrapped by chitosan, after aldehyde group is formed, and functional monomer grafting, and the gamma-seleno butyrolactone obtained by reaction again.The water-based polyurethane coating prepared in the application has good flame-retardant, antibacterial, anti-aging and self-repairing performance.

The application discloses a method for preparing aromatic benzyl propargyl ketone by light induction and biological application, belongs to the technical field of organic synthesis and biological medicine, and converts aromatic benzyl propargyl alcohol into aromatic benzyl propargyl ketone under the condition of light induction; the change of the functional group before and after light induction is that the hydroxyl alkyne without reaction activity is converted into the carbonyl alkyne with click reaction activity, fluorescence enhancement can be realized, and the method can be used for imaging and tracing; and the aromatic benzyl propargyl ketone can react with a compound containing an amino group or a biological macromolecule to realize the killing of tumor cells. The method uses light as a starting switch, the reaction condition is simple, controllability is good, no additional catalyst is needed, and the method is easy to mass-produce, so the method has wide application prospects in polypeptide or protein labeling, anti-tumor and the like.

The application provides a base-promoted system for synthesizing alkenyl borate from propargyl alcohol compounds, which comprises propargyl alcohol compounds, a diboron reagent, a base and a solvent. The application also provides an application of the base-promoted system, which is used for synthesizing alkenyl borate from propargyl alcohol compounds through a borohydride reaction. The method is as follows: under the action of a base and a solvent, a borohydride reaction of propargyl alcohol compounds is promoted by using a diboron reagent as a boron source, so as to synthesize alkenyl borate in a trans stereospecific and beta-regioselective manner. In the reaction system, the trans stereospecific and beta-regioselectivity of the borohydride addition of propargyl alcohol compounds are realized, and a transition metal catalyst is not needed, and the system has the advantages of wide substrate application range, high conversion rate and mild reaction conditions.

The invention discloses a process for preparing 3-chloropropyne through concerted catalysis of phosphine ligand-transition metal in the technical field of organic synthesis. The process realizes efficient synthesis through specific steps: firstly, mixing a porous nitrogen-doped carbon-loaded phosphine ligand-metal nano composite material, palladium chloride and triethylamine under the protection of nitrogen to form a catalytic system; dissolving propargyl alcohol and N-chlorosuccinimide in anhydrous tetrahydrofuran, and mixing in an ice bath to obtain a pre-reaction mixture; then adding the pre-reaction mixture into a catalytic system, stirring and reacting at a specific temperature under the protection of nitrogen, and monitoring the progress through thin layer chromatography in the reaction; and after the reaction is finished, filtering and separating the catalyst, evaporating filtrate under reduced pressure to remove the solvent, and purifying by column chromatography to obtain a target product. The process is high in catalytic efficiency, good in selectivity, high in product yield and environment-friendly.

This application provides a method for preparing methylcarboxylic acid-2-propynyl ester, comprising the following steps: (1) mixing dimethyl carbonate and propargyl alcohol, adding a first alkaline catalyst, stirring and heating to a temperature of 90-105°C, and distilling out methanol by reactive distillation to obtain a first component; (2) performing solid-liquid separation on the first component to obtain a first liquid, and performing vacuum distillation on the first liquid to remove propargyl alcohol and dimethyl carbonate to obtain methylcarboxylic acid-2-propynyl ester and residue; (3) performing vacuum distillation on the residue, replenishing dimethyl carbonate and the second alkaline catalyst with the distillate for reaction, and reusing the reaction liquid in step (2). This application uses the transesterification reaction of propargyl alcohol and dimethyl carbonate to synthesize methylcarboxylic acid-2-propynyl ester, which has high safety, low overall reaction temperature, fewer by-products and waste, and high yield.

The invention belongs to the field of new materials, and discloses a preparation method of 1-propylene-1, 3-sultone, which comprises the following steps: step 1, addition reaction: using propargyl alcohol and alkali metal sulfite and / or alkali metal hydrosulfite as raw materials, and carrying out addition reaction in the presence of a catalyst and a free radical initiator to obtain an addition product; step 2, acidification reaction: adjusting the pH value of the addition product to 4 or below 4, and separating to obtain an acidified product; step 3, cyclization reaction: carrying out cyclization reaction on the acidified product to obtain 1-propylene-1, 3-sultone; the catalyst is soluble metal salt which is soluble in water. According to the method, the catalyst and the free radical initiator which are low in price are compounded, so that a product with relatively good conversion rate and selectivity is obtained.

The application discloses a kind of diindole derivatives and preparation method thereof, it is left-handed or right-handed optical active body or racemate with the following structural formula;Its preparation includes with isoindoline group propargyl alcohol compound and 2-indole methanol compound as raw material, with organic phosphoric acid catalyst as catalyst, reaction is obtained in organic solvent diindole derivative.The application utilizes catalytic tandem reaction method to synthesize diindole derivative, reaction condition is mild, process is simple, operation is convenient, the potential fluorescent property and biological activity of obtained product, this will have important significance to fluorescent material and synthesis drug screening.

The invention relates to the field of organic synthesis, in particular to a preparation method of a 6-arylvinyl-6-phosphono-5, 6-dihydroindeno [2, 1-b] indole compound. The preparation method comprises the following steps: mixing an indole ring-containing benzene propargyl alcohol compound, a phosphine oxide compound, a catalyst and a solvent to obtain a mixture, and carrying out a cyclic isomerization reaction to obtain the 6-arylvinyl-6-phosphono-5, 6-dihydroindeno [2, 1-b] indole compound. The preparation method provided by the invention is wide in substrate application range, can be used for synthesizing compounds with different molecular structures, is mild in reaction condition, cheap and easily available in reagent, good in atom economy, simple and convenient in product post-treatment and high in yield, and is suitable for industrial production and promotion of practical application.

The invention relates to a 2-aroyl-1, 5-diaryl-1, 5-pentanedione derivative and a synthesis method and application thereof.The synthesis method comprises the steps that 3-aryl propargyl alcohol and 1, 3-diaryl-1, 3-propanedione are subjected to a series Meyer-Schuster rearrangement / nucleophilic addition reaction in the presence of a first catalyst and a first organic solvent, and the 2-aroyl-1, 5-diaryl-1, 5-pentanedione derivative is obtained; the invention discloses a 1, 5-pentanedione derivative. Compared with the prior art, the 2-aroyl-1, 5-diaryl-1, 5-pentanedione derivative prepared by the preparation method disclosed by the invention has no substituent group at the position 3, has good fluorescence emission performance and metal ion recognition performance, can be used as an organic small molecule fluorescent material molecule, and is applied to the fields of metal ion detection, fluorescent probes and the like.

The invention discloses a method for synthesizing dialkyl substituted chiral alpha-hydroxy ketone from propargyl alcohol ester, which specifically comprises the following steps of: reacting propargyl alcohol ester and acid serving as substrates and metal palladium serving as a catalyst in an organic solvent under the regulation and control of a specific chiral ligand, and adding alkali for treatment after the reaction is finished to obtain optically pure (88-97% ee) alpha-hydroxy ketone. The product provided by the invention is carbonyl alpha-position chiral secondary alcohol with a chain structure, and has a dialkyl substituted structure with high regioselectivity; the catalyst and the ligand are wide in source, and the substrate is cheap and easily available; and the method has excellent enantioselectivity and good functional group compatibility, can be suitable for structural modification of bioactive molecules and intermediates, and is a simple and efficient asymmetric catalysis strategy for synthesizing the dialkyl substituted chiral alpha-hydroxy ketone.

The invention relates to the fields of coordination chemistry and metal organic chemistry, and discloses a metal-only center chiral osmium carbon dragon complex as well as a preparation method and application thereof. According to the synthesis method, a chiral polyalkyne carbon chain (a carbon dragon ligand precursor containing a propargyl alcohol structure unit) with pure enantiomers is reacted with a metal osmium source OsCl2 (PAr3) 3, and the chirality of a carbon center on the polyalkyne carbon chain is transferred to the chirality of a metal center of the carbon dragon complex through a chiral transfer strategy, so that the one-pot preparation of the metal-center-only chiral osmium carbon dragon complex is realized. The synthesis method has the characteristics of simplicity and convenience in operation, easiness in separation, mild reaction conditions, easiness in obtaining of raw materials, good universality of reactants and the like. And meanwhile, the obtained metal-center-only chiral osmium carbon long complex can react with various reagents such as m-chloroperoxybenzoic acid / sulfur powder / tin powder / cuprous chloride / silver tetrafluoroborate, phenanthroline / triphenylphosphine gold chloride / acetonitrile / pyridine / imidazole and the like, so that further derivatization is realized, and a series of brand new metal-center-only chiral osmium carbon long complexes are obtained. The metal-only center chiral osmium-penta-oxa three-membered ring complex provided by the invention can be used for efficiently catalyzing an asymmetric Michael addition reaction of indole and an alpha-hydroxyl-alpha ', beta'-unsaturated ketone compound.

The invention discloses a coupling reaction of palladium-catalyzed secondary propargyl alcohol benzoate and sulfonamide to realize high-selectivity synthesis of 2-amido-substituted conjugated diene, and the method is suitable for coupling of a series of functionalized propargyl alcohol benzoate and sulfonamide. In addition, later-stage functional modification of complex small molecule drugs can be achieved through the method, a new method is provided for synthesis of sulfonamide compounds containing conjugated diene structures, and the method has important application prospects.

The invention relates to the technical field of wastewater treatment equipment, and discloses propargyl alcohol production wastewater treatment equipment which comprises a temporary storage detection pool used for receiving and temporarily storing mother liquor wastewater generated in the propargyl alcohol production process and detecting the concentration content of propargyl alcohol in the mother liquor wastewater; and the mother liquor diversion mechanism is used for carrying out diversion treatment on middle-low-concentration mother liquor wastewater and high-concentration mother liquor wastewater generated in the propargyl alcohol production process according to the concentration of propargyl alcohol in the mother liquor wastewater. By adding and arranging the micro-electric reaction mechanism, when mother liquor wastewater generated in the propargyl alcohol production process is treated, the mechanism not only can break refractory chemical bonds of propargyl alcohol through micro-electrolysis reaction and reduce the toxicity of the wastewater, but also can deeply decompose pollutants such as formaldehyde and the like in combination with Fenton oxidation; a suitable water quality condition is created for a subsequent biodegradation link, and the problem that degradation efficiency is low due to the fact that refractory organics directly enter a biochemical system in a traditional full-degradation route is solved.

The invention belongs to the technical field of chemical reaction prediction, and discloses an analysis method for a tandem cyclization reaction mechanism of double-metal system catalyzed pyridyl homopropargyl alcohol and propargyl alcohol. The analysis method comprises the following steps: (1) respectively constructing calculation models of an Au (I) catalyst, a Cu (II) catalyst and a substrate pyridyl high-propargyl alcohol structure and a substrate pyridyl high-propargyl alcohol structure; (2) designing a reaction path under an Au (I) catalyst and a Cu (II) catalyst, and constructing an intermediate and a transition state; (3) screening a catalyst for catalytic synthesis of 2, 3-dihydrofuran and polycyclic dihydrobenzofuran; and (4) analyzing the reaction mechanism and path under the Au (I) catalyst and the Cu (II) catalyst. According to the invention, a highly coordinated bimetallic catalytic mechanism is emphasized by applying a density functional theory, and a valuable insight is provided for understanding and designing the bimetallic catalytic mechanism. The result obtained by the analysis method is very consistent with the experimental result, and the calculation result is accurate and reliable.

The invention discloses a polyaryl substituted benzo six-membered heterocyclic antitumor compound and a synthesis method thereof. The chemical structural formula of the compound is shown as a formula 3. The synthesis method comprises the following steps: adding polyaryl substituted propargyl alcohol and o-hydroxyphenyl substituted secondary phosphine oxide serving as reaction raw materials into 1, 2-dichloroethane, stirring and reacting for 22-26 hours at room temperature under the catalysis of tetrafluoroboric acid tetraacetonitrile copper, then adding DBU, reacting for 5-7 hours, concentrating and purifying to obtain the polyaryl substituted propargyl alcohol and o-hydroxyphenyl substituted secondary phosphine oxide. According to the polyaryl substituted benzo six-membered heterocyclic compound synthesized by the invention, a biological activity test shows that the derivative has relatively high sensitivity and very strong cytotoxic activity to human breast cancer cells MCF-7. The reaction conditions are relatively conventional, the reaction process is mild, simple and convenient, the operation is easy, and the cost is low; according to the method, various substrates are used as reactants, products with various structures are obtained, and the yield is high.

The invention discloses a copper monatomic catalyst with stable N-heterocyclic carbene as well as a preparation method and application of the copper monatomic catalyst with stable N-heterocyclic carbene. According to the method, construction of a porous organic polymer carrier and anchoring of metal monatomic active sites are innovatively combined, and the copper monatomic catalyst with stable N-heterocyclic carbene is prepared through a one-pot mechanical grinding strategy. A triazine compound, a nitrogen-containing heterocyclic compound, a copper salt and alkali directly react under the assistance of no solvent or a trace amount of solvent, and the catalyst POP-n-NHC-CuX (n = I-IV, X = Cl, Br or I) is obtained through in-situ synchronous synthesis. In the obtained catalyst, copper atoms are stably anchored on a polymer skeleton in a coordination bond form through an NHC ligand to form atomic-scale dispersed active sites. The catalyst can efficiently catalyze the conversion reaction of CO2 and propargyl alcohol and derivatives thereof under mild conditions, is suitable for synthesizing various high value-added chemicals including alpha-alkylene cyclic carbonate, oxazolidinone and beta-oxypropyl carbamate, and shows excellent catalytic cycle stability and substrate universality.

The invention discloses a preparation method of a cyclic 1, 2-oxaacid ester derivative, and belongs to the technical field of organic synthesis. It is found for the first time that NaHMDS serving as alkali can promote activation of a borohydride reagent, trans-addition of propargyl alcohol is achieved, and five-membered ring 1, 2-oxaboric acid can be constructed in one step. The method has the advantages of mild reaction conditions, wide substrate range, strong functional group tolerance and specific regioselectivity. In addition, the cyclic 1, 2-oxaboric acid is also a bioisostere of a butenolactone structure, and is expected to have considerable biological activity.

The present application relates to the technical fields of organic compound synthesis method, and particularly relates to a trifluoromethyl-containing sultone derivative and a preparation method and application thereof.The preparation method of the trifluoromethyl-containing sultone derivative of the present application comprises the following steps: (1) sulfonation reaction: addition reaction of propargyl alcohol and alkali metal sulfite or alkali metal bisulfite to obtain an intermediate 3-hydroxy propenyl sulfonate; (2) cyclization reaction: acidification treatment of the intermediate 3-hydroxy propenyl sulfonate to obtain 3-hydroxy propenyl sulfonic acid, and then ring closure reaction to obtain 1-propen-1, 3-sultone; (3) fluorination reaction: reaction of 1-propen-1, 3-sultone with a suitable fluorination reagent to obtain the trifluoromethyl-containing sultone derivative.The preparation method of the compound is simple and easy to operate, the raw materials are cheap and easy to obtain, the reaction conditions are mild, and the compound is a functional material with wide application prospect and can be applied as an electrolyte additive.

The invention discloses an isoindole aggregation-induced emission molecule containing a phosphine oxide structure and a synthesis method of the isoindole aggregation-induced emission molecule, and belongs to the technical field of organic synthesis. O-propargyl alcohol benzaldehyde, arylamine and diaryl phosphine oxide are used as raw materials, the phosphine-containing isoindole derivative is efficiently synthesized under mild conditions through a one-pot cascade reaction, the method shows excellent atom economy and operation convenience, and it is found through substrate expansion research that the phosphine-containing isoindole derivative has a wide application prospect. The reaction has good compatibility to various functional groups, and steric hindrance and electronic effect have significant influence on reaction activity. Photophysical property characterization proves that the obtained phosphine-containing isoindole derivative has typical AIE characteristics, and the fluorescence intensity in an acetonitrile / water mixed solvent is remarkably enhanced along with the increase of the water content. Therefore, the invention not only provides a new thought for green synthesis of an isoindole skeleton, but also lays a foundation for application of the isoindole skeleton in the field of functional materials.