Preparation method of ferroferric oxide nanoparticles

Abstract

The invention relates to a preparation method of ferroferric oxide nanoparticles, relating to the field of preparation of inorganic non-metallic nano materials. The preparation method comprises the steps of: firstly, preparing a mixed dispersion solution of a ferric source and a ferrous source and a dispersion solution of an alkali source, adding the prepared mixed dispersion solution of the ferric source and the ferrous source into the dispersion solution of the alkali source, stirring for reaction for 50-70min to generate black precipitates in a reaction process, delivering reactants to a centrifuger, washing the separated precipitates sequentially with distilled water, a water-alcohol solution and absolute ethyl alcohol, centrifuging, separating and drying to obtain ferroferric oxide nanoparticles. In the invention, a used reaction solvent has the advantages of low cost and no toxicity and harmfulness, can be recycled and has no environment pollution problem; and used equipment is simple, operation conditions are easy to master, and thus, large-scale production is convenient.

Description

[0001] technical field [0002] The invention relates to a preparation method of nanomaterials, in particular to a preparation method of iron ferric oxide nanoparticles, belonging to the field of preparation of inorganic nanomaterials. Background technique [0003] In recent years, nanotechnology has developed rapidly, and nanomaterials have attracted more and more attention because of their unique properties different from ordinary materials. [0004] Ferroferric oxide nanoparticles have a unique structure, good magnetic properties and biocompatibility, and are widely used in the fields of magnetic media storage, magnetic fluid, catalysis, magnetic pigments and biomedicine. Especially in the field of biomedicine, ferric iron tetroxide nanoparticles have great potential in magnetic immune cell separation, cell therapy, tissue repair, targeted drug delivery, tumor hyperthermia therapy and magnetic embolization therapy, magnetic response imaging, enzyme immobilization and immu...

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Problems solved by technology

The preparation of nano-ferric oxide by ball milling has good reproducibility and simple operation, but the production cycle is long, the particle size refinement is difficult to meet the nano-scale requirements, and the particle size distribution is uneven, and it is easy to be oxidized during the preparation process; the microemulsion method prepared Nanoparticles have small particle size and good monodispersity, but the surfactants, co-surfactants and oils introduced in the synthesis process have to be washed repeatedly with organic solvents, and it is not easy to remove; although the hydrothermal method can control the crystal structure of nanoparticles and purity, but because the reaction is carried out in a high-pressure reactor, the equipment requirements are relatively high, resulting in high costs; the sol-gel method prepares nano-ferric oxide with various crystal forms; the vapor deposition method is costly and difficult to operate The common co-precipitation process is simple and can synthesize iron ferric oxide nanoparticles in a large amount, but it is difficult to control the particle size and particle size distribution of the product. The prepared nano ferric oxide particle size distribution range is wide and does not have good dispersion. properties, and during the preparation process, the proportion of the reaction changes due to the fact that ferrous ions are easily oxidized to ferric ions in the air

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