A preparation method of an amphiphilic surfactant and a controllable preparation method of zwitterionic nano hollow capsules

Abstract

The invention discloses a preparation method of an amphiphilic surfactant and a controllable preparation method of zwitterionic nano hollow capsules, wherein 2-(dodecyltrithiocarbonate)-2-methylpropionic acid is dissolved in In the dioxane solvent, dissolve the hydrophilic monomer, lipophilic monomer and azobisisobutyronitrile in benzyl alcohol, mix the above two solutions evenly, after the polymerization reaction, remove the solvent by ice methanol precipitation and vacuum drying Amphiphilic surfactants are produced. Based on this reagent, zwitterionic nano-hollow capsules are prepared by reverse-phase RAFT mini-emulsion interfacial polymerization. The amount of this reagent can be used to adjust the particle size of the prepared nano-hollow capsules, and further by adjusting the amount of cross-linking agent and core-shell By changing the ratio, the shell structure of zwitterionic hollow nanocapsules can be adjusted, which solves the problem that the structure and particle size of traditional nanocapsules are difficult to controllably prepare.

Description

technical field [0001] The invention relates to a preparation method of an amphiphilic surfactant and the application of the amphiphilic surfactant to prepare a zwitterionic nanometer hollow capsule, and belongs to the technical field of preparing functional polymer materials by an active controllable free radical polymerization method. Background technique [0002] Surfactant refers to a substance that can significantly change the interface state of its solution system by adding a small amount. The reason why amphiphilic molecules can be used as surfactants is that one end is a hydrophilic group and the other end is an lipophilic group. Therefore, amphiphilic molecules will be enriched at the water-oil interface, reducing the surface tension and surface free energy of the phase interface, thereby achieving its emulsification effect. Compared with typical small-molecule surfactants, polymeric surfactants mainly have the following outstanding characteristics: (1). The water ...

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Problems solved by technology

Among them, the LBL method uses colloidal particles (such as latex or cells) of active ingredients as an assembly template, alternately adsorbs substances with opposite charges, attracts each other through electrostatic attraction and aggregates or deposits on the surface of template particles, and self-assembles layer by layer to form a two-dimensional or Three-dimensional particles with a core-shell structure can regulate and modify the shell, but the preparation process is cumbersome, and it is not suitable for preparing nanopolymer capsules with a hollow structure with a diameter of less than 200nm; the block copolymer assembly method is Assemblies prepared by block polymer copolymers generally range in size from 10 to 1000 nm, but the self-assembly steps of block copolymers are usually cumbersome, and it is difficult to better control the structure of the assembly

The traditional miniemulsion polymerization method is simple and can prepare nano-polymer capsules with a particle size distribution of 50-500nm, but there are problems such as low hollow ratio and difficult structure adjustment

[0004] To sum up, many scholars have done a lot of research work on the preparation of nano-hollow capsules, and proposed a variety of preparation methods, but the particle size and core-shell structure are difficult to precisely control, which limits its further application.

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