Preparation process for non-cleaning carboxyl polystyrene microspheres

Abstract

The invention discloses a preparation process for non-cleaning carboxyl polystyrene microspheres. The process comprises the following steps: (1) pouring a functional monomer solution into an outer aqueous-phase solution at one time, wherein the functional monomer is one or more selected from acrylic acid, methacrylic acid and ethyl acrylate, performing stirring, and adding an initiator to initiatea polymerization reaction; and (2) when the initiated polymerization is performed for 5 min to 2 h, adding a mixture of styrene and divinylbenzene at one time, performing a reaction for a period of time, performing cooling, and performing filtration to obtain the carboxyl polystyrene microspheres. The particle size and carboxyl content of the carboxyl polystyrene microspheres prepared by the process are controllable, the reaction time is shortened, and no or only a small amount of time is required for post-treatment.

Description

technical field [0001] The invention relates to the field of medical inspection, in particular to a preparation process of no-cleaning carboxyl polystyrene microspheres. Background technique [0002] In the latex-enhanced immune turbidimetric method, latex microspheres are used as an indispensable main component, and its general preparation process is as follows: as described in the patent CN101775094B: after styrene removes the polymerization inhibitor; styrene, methyl Add acrylic acid and water to the three-necked flask and stir for 10-30 minutes; after stirring, inject an appropriate amount of N2 to drive away the oxygen in the system; after deoxygenation, add an initiator to initiate polymerization within the range of 60-80°C, react for 12-24 hours and then cool to room temperature; Then several times of centrifugal sedimentation, washing and reconstitution; thereby obtaining polystyrene microspheres with carboxyl groups on the surface. [0003] Mainly there are followi...

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Problems solved by technology

[0004] First, in the absence of emulsifiers and cross-linking agents, adding styrene and methacrylic acid to water and stirring cannot form a uniform oil-in-water emulsion, resulting in uneven particle size of the final latex and uneven distribution of carboxyl groups , resulting in poor application performance; moreover, styrene and functional monomers are added at the same time to initiate polymerization, which will lead to three polymerization forms in the system: styrene and styrene polymerization, styrene and functional monomer polymerization, functional monomer self- Polymerization; the three polymerization rates are different, which may easily lead to uneven distribution of carboxyl groups on the surface and uncontrollable carboxyl content, which has a great influence on the repeatability of latex batches

[0005] Secondly, in the above method, the reaction time is generally 6-8h, and the reaction time is longer

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