The invention provides a multi-section feeding type anti-
solvent spraying crystallizer and a spraying
crystallization method thereof. The crystallizer is a tubular crystallizer which is vertically arranged, wherein a main
pipe inlet (1) is formed in the upper part of the tubular crystallizer; small holes or slits (2) which are symmetrically distributed are formed in positions with different heights of a main
pipe wall from top to bottom; buffering chambers (3) are arranged around the small holes or the slits (2) in the positions with the same height; a side feeding opening (4) is formed in each buffering chamber; a main
pipe outlet (5) is formed in the lower part of the tubular crystallizer. According to the multi-section feeding type anti-
solvent spraying crystallizer provided by the invention, a
solution system A with a certain concentration is prepared by dissolving heterocyclic organic
medicine particles, inorganic salt or
oxide and particles P of a
nitryl energy-containing material into a good
solvent S; crude particles P are recrystallized by adopting the tubular crystallizer; the
solution system A and a bad solvent are rapidly mixed to continually form a
crystal nucleus andthe
crystal nucleus grows continually; finally, a suspension solution containing fine particles P is obtained at an outlet of the spraying crystallizer. The particle products obtained by the method have the advantages of controllable grain
diameter sizes and distribution, narrow grain
diameter distribution and the like.