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Magnetic lignin nano drug carrier

A technology of lignin and magnetism, which is applied in the preparation method of magnetic lignin nanoparticles and the field of pharmaceutical compositions, can solve problems such as poor water solubility, achieve the effects of reducing toxic and side effects, improving utilization rate, and simple and feasible method

Inactive Publication Date: 2018-02-16
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Purified lignin and lignin derivatives are soluble in organic solvents such as chloroform, dioxane, and tetrahydrofuran, but have poor water solubility

Method used

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  • Magnetic lignin nano drug carrier

Examples

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Effect test

Embodiment 1

[0028] Embodiment 1: Preparation of Magnetic Alkali Lignin Nanoparticles

[0029] The purified alkali lignin was dissolved in 2 ml of methanol, and the aqueous solution of iron ferric oxide nanoparticles was added dropwise into the composite solution, and stirred at room temperature by magnetic force. After the dropwise addition, the stirring was continued for 20 minutes to obtain a dispersion system of lignin nanoparticles loaded with resveratrol, which was purified by dialysis, centrifuged and dried in vacuum to obtain the product magnetic alkali lignin nanoparticles.

[0030] Description: In this example, the concentration of alkali lignin is 0.1-4 mg / mL, preferably 0.5 mg / mL; the volume percentage of water added is 50-95%, preferably 87.5%; the content of ferric oxide in water It is 0.05 to 10%, preferably 1%.

Embodiment 2

[0031] Example 2: Preparation of lignin / resveratrol / ferric oxide composite nanoparticles

[0032] The purified alkali lignin and resveratrol were dissolved in 2 mL of methanol at room temperature to obtain a composite solution, and the aqueous solution of iron ferric oxide nanoparticles was added dropwise to the composite solution, at room temperature, and magnetically stirred. After the dropwise addition, continue to stir for 20 minutes to obtain a lignin nanoparticle dispersion system loaded with resveratrol, and then undergo dialysis purification, centrifugal precipitation, and vacuum drying to obtain the product lignin / resveratrol / trioxide Iron composite nanoparticles.

[0033] Description: In this example, the concentration of lignin is 0.1-4 mg / mL, preferably 0.5 mg / mL; the concentration of resveratrol is 0.5-5 mg / mL, preferably 1 mg / mL; the volume percentage of water added 50-95%, preferably 87.5%; the content of ferric oxide in water is 0.05-10%, preferably 1%.

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Abstract

The invention discloses a preparation method and pharmaceutical composition of a plurality of magnetic lignin nanoparticles. Nano micelles are prepared by selecting lignins (such as alkaline lignin, milled wood lignin, Kraft lignin and mixtures thereof). One lignin and liposoluble drugs are dissolved in an organic solvent respectively, and then an aqueous solution of magnetic nanoparticles is slowly dropwise added for self-assembly to form nanoparticles. The pharmaceutical composition contains the lignin nanoparticles, the magnetic nanoparticles and drugs insoluble in water. The magnetic lignin nanoparticles can be used as a drug carrier, can improve the water dispersibility of poorly soluble drugs, reduces toxicity and prolongs the cyclic half-life in organisms.

Description

technical field [0001] The invention belongs to the technical field of nanocomposite materials, and in particular relates to a preparation method and a pharmaceutical composition of magnetic lignin nanoparticles. Background technique [0002] Polymeric nanoparticles have received increasing attention in the field of drug delivery. The particle size of polymer nanoparticles is generally 10-100nm, which has the characteristics of high drug loading, wide drug loading range, good stability, and long residence time in vivo. It has unique in vivo distribution characteristics and can improve drug stability. , can not only achieve passive targeted drug delivery, but also connect ligands with specific recognition functions to achieve active targeting, thereby significantly improving the bioavailability of drugs and reducing their toxic and side effects. [0003] In recent years, food and drug safety has received the attention of the whole people, and unique, green and safe natural p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/30A61K8/72A23L29/00
Inventor 戴林司传领刘瑞
Owner TIANJIN UNIV OF SCI & TECH
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