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Crease resistance and moisture retention liposome, and preparation method and application thereof

A technology of moisturizing fat and blank liposome, which is applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of easy inactivation of ceramides, and it is difficult to directly use anti-wrinkle and moisturizing ingredients, so as to achieve easy absorption, improve Effects of stability and bioavailability, large histocompatibility

Active Publication Date: 2015-10-28
西安艾尔菲生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a kind of anti-wrinkle moisturizing liposome, this liposome wraps three kinds of components of superoxide dismutase, hyaluronic acid and ceramide at the same time, has solved superoxide dismutase, hyaluronic acid in the prior art and the problem of easy inactivation of ceramide
[0009] The second object of the present invention is to provide the preparation method of the above-mentioned anti-wrinkle moisturizing liposome, which solves the problem that the existing liposome only contains one or two components
[0010] The third object of the present invention is to provide the application of the above-mentioned anti-wrinkle moisturizing liposome, which solves the problem that it is difficult to directly utilize the above-mentioned anti-wrinkle moisturizing ingredients in existing cosmetics

Method used

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  • Crease resistance and moisture retention liposome, and preparation method and application thereof
  • Crease resistance and moisture retention liposome, and preparation method and application thereof
  • Crease resistance and moisture retention liposome, and preparation method and application thereof

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preparation example Construction

[0041] The present invention also provides the preparation method of the above-mentioned anti-wrinkle moisturizing liposome, refer to figure 1 , including the following steps:

[0042] Step 1, prepare blank liposome suspension

[0043] Dissolving phospholipids, cholesterol, Tween-80 and antioxidants in absolute ethanol to obtain a raw material solution, wherein the mass ratio of the total mass of phospholipids, cholesterol, Tween-80 and antioxidants to absolute ethanol is 1:3~ 1:5; Rotate the raw material solution, control the temperature of the water bath at 35-45°C, rotate at a speed of 20-100r / min, and maintain the vacuum at 0.010-0.027MPa until the solvent is removed and the raw material solution forms a thin film on the wall of the flask ; Add the lyoprotectant to the phosphate buffer with a pH value of 6.5-7.0 and mix thoroughly, then wash the film to obtain an emulsion, and then place the emulsion in a magnetic stirrer to control the temperature at 40-45 ℃, rotation s...

Embodiment 1

[0056] A kind of anti-wrinkle moisturizing liposome is prepared, comprising the following steps:

[0057] Step 1, prepare blank liposome suspension

[0058] Weigh the following raw material components by mass percentage: soybean lecithin 2g; cholesterol 1g; antioxidant 0.1g; Tween-80 1g; lyoprotectant 4g; 0.8g of aqueous solution; 0.8g of hyaluronic acid aqueous solution with a molecular weight of 100,000; 0.8g of type I ceramide aqueous solution.

[0059] Wherein, the concentration of the superoxide dismutase aqueous solution is 10 mg / mL, the antioxidant is a mixture of vitamin E and vitamin C with a mass ratio of 3:1, the concentration of the aqueous solution of hyaluronic acid is 10 mg / mL, and the concentration of the aqueous solution of type I ceramide is 10mg / mL, the lyoprotectant is a mixture of sucrose and mannitol in a mass ratio of 1:1.

[0060] Soybean lecithin, cholesterol, Tween-80 and anti-oxidant are dissolved in 12g absolute ethanol, the mass ratio that makes ...

Embodiment 2

[0068] A kind of anti-wrinkle moisturizing liposome is prepared, comprising the following steps:

[0069] Step 1, prepare blank liposome suspension

[0070] Weigh the following raw material components by mass percentage: egg yolk lecithin 4g; cholesterol 2g; antioxidant 0.2g; Tween-80 2g; lyoprotectant 8g; pH 6.8 phosphate buffer 178g; 2g of aqueous solution; 2g of hyaluronic acid aqueous solution with a molecular weight of 100,000; 2g of type III ceramide aqueous solution.

[0071] Among them, the concentration of superoxide dismutase aqueous solution is 17 mg / mL, the antioxidant is tert-butylhydroquinone, the concentration of hyaluronic acid aqueous solution is 17 mg / mL, the concentration of type III ceramide aqueous solution is 17 mg / mL, and the lyoprotectant It is made by mixing maltose and mannitol in a mass ratio of 1:1.

[0072] Egg yolk lecithin, cholesterol, Tween-80 and antioxidant are dissolved in 32g absolute ethanol, so that the mass ratio of the total mass of e...

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Abstract

The invention discloses a crease resistance and moisture retention liposome. The crease resistance and moisture retention liposome comprises, by mass, 1-3% of phosphatide, 0.5-1.5% of cholesterol, 0.05-0.15% of an antioxidant, 0.5-1.5% of Tween-80, 2-6% of a cryoprotectant, 84-94% of a phosphate buffering solution with the pH value of 6.5-7, 0.4-1.5% of an aqueous solution of superoxide dismutase, 0.4-1.5% of an aqueous solution of hyaluronic acid and 0.4-1.5% of an aqueous solution of ceramide, and the sum of the mass percentages of above components is 100%. The invention discloses a preparation method of the crease resistance and moisture retention liposome. The method comprises the following steps: preparing a blank liposome, wrapping active components by the blank liposome, and carrying out freeze-thawing and freeze-drying to prepare the crease resistance and moisture retention liposome. The crease resistance and moisture retention liposome can be added to cosmetics in order to prepare cosmetics with crease resistance and moisture retention efficacies.

Description

technical field [0001] The invention belongs to the technical field of preparation of cosmetic raw materials, in particular to an anti-wrinkle moisturizing liposome, and also relates to a preparation method and application of the anti-wrinkle moisturizing liposome. Background technique [0002] Free radicals are harmful compounds produced in the body's oxidation reaction. They have strong oxidative properties and can damage skin tissues and cells, causing skin to sag and thin to produce aging effects. Therefore, adding free radical scavengers to cosmetics has attracted more and more attention; at the same time, when the water content of the stratum corneum of the skin is lower than 10%, the skin will be rough and even chapped to produce aging effects. Therefore, keeping the skin hydrated with the right moisturizer is essential for anti-aging. [0003] Anti-wrinkle active ingredients in cosmetics are mainly divided into active ingredients that affect the growth and metabolis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/66A61K8/68A61K8/55A61K8/63A61K8/14A61Q19/00A61Q19/08
Inventor 马双王静赵文静胡春梅
Owner 西安艾尔菲生物科技有限公司
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