Preparation method of high-strength self-healing hydrogel

A hydrogel, high-strength technology, applied in the fields of pharmaceutical formula, medical science, prosthesis, etc., can solve the problems of limiting the scope of use of self-healing hydrogel, poor biocompatibility, poor mechanical strength, etc., to achieve good self-healing Synergistic properties, delayed release, and long service life

Inactive Publication Date: 2017-08-18
CHANGZHOU YAHUAN ENVIRONMENTAL PROTECTION TECH
View PDF3 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention: Aiming at the problem that the traditional self-healing hydrogel has poor mechanical strength, short service life, and poor biocompatibility, which limits the scope of use of the self-healing hydrogel, a polymer based Vinyl alcohol and polyacrylamide are cross-linked, and the self-polymerization of dopamine is used to absorb self-made nano-hydroxy calcium phosphate to prepare a high-strength self-healing hydrogel. In the present invention, polyvinyl alcohol is first dissolved, and acrylamide solution is added to form N,N'-methylenebisacrylamide is used as a cross-linking agent, and nano-titanium dioxide is used as a free radical initiator. First, acrylamide is polymerized under ultr

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0017] Example 1

[0018]First weigh 100g of polyvinyl alcohol, and pour the polyvinyl alcohol into a beaker filled with 1000mL of deionized water at a temperature of 20°C under the stirring state of a glass rod. Stir and mix at a constant temperature for 90 minutes at a temperature of 90°C and a rotational speed of 300r / min in an agitator, and wait for natural cooling to room temperature to obtain a polyvinyl alcohol solution; then transfer the polyvinyl alcohol solution obtained above into a conical flask, Then add 600mL of 10% acrylamide solution, 0.4g of N,N'-methylenebisacrylamide, 2g of nano-titanium dioxide, and place the Erlenmeyer flask in an ultrasonic oscillator. Treat for 45 minutes; after the ultrasonic treatment is finished, seal the above-mentioned Erlenmeyer flask with a rubber stopper, and use a UV lamp with a power of 80W to continuously irradiate the Erlenmeyer flask for 3h, then transfer the material in the Erlenmeyer flask to a refrigerator, and store it a...

Example Embodiment

[0020] Example 2

[0021] First weigh 110g of polyvinyl alcohol, and pour the polyvinyl alcohol into a beaker filled with 1250mL of deionized water at a temperature of 23°C under the stirring state of a glass rod. Stir and mix at a constant temperature for 105 minutes at a temperature of 93°C and a rotational speed of 350r / min in a stirrer, and wait for natural cooling to room temperature to obtain a polyvinyl alcohol solution; then transfer the polyvinyl alcohol solution obtained above into a conical flask, Then add 700mL of 11% acrylamide solution, 0.5g of N,N'-methylenebisacrylamide, 3g of nano-titanium dioxide, and place the Erlenmeyer flask in an ultrasonic oscillator. Treat for 53 minutes; after the ultrasonic treatment is completed, seal the above-mentioned Erlenmeyer flask with a rubber stopper, and continuously irradiate the Erlenmeyer flask with an ultraviolet lamp at a power of 100W for 4 hours, then transfer the material in the Erlenmeyer flask to a refrigerator, a...

Example Embodiment

[0023] Example 3

[0024] First weigh 120g of polyvinyl alcohol, pour the polyvinyl alcohol into a beaker filled with 1500mL of deionized water at a temperature of 25°C while stirring with a glass rod, continue stirring and mixing for 20 minutes, then turn the beaker into a digital display speed measuring constant temperature magnetic Stir and mix at a constant temperature for 120 minutes at a temperature of 95°C and a rotational speed of 400r / min in a stirrer, and wait for natural cooling to room temperature to obtain a polyvinyl alcohol solution; then transfer the polyvinyl alcohol solution obtained above into a conical flask, Then add 800mL of 12% acrylamide solution, 0.6g of N,N'-methylenebisacrylamide, 4g of nano-titanium dioxide, and place the Erlenmeyer flask in an ultrasonic oscillator. Treat for 60 minutes; after the ultrasonic treatment is finished, seal the above-mentioned Erlenmeyer flask with a rubber stopper, and continuously irradiate the Erlenmeyer flask with a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Tensile strengthaaaaaaaaaa
Tensile strengthaaaaaaaaaa
Tensile strengthaaaaaaaaaa
Login to view more

Abstract

The invention discloses a preparation method of high-strength self-healing hydrogel and belongs to the technical field of preparation of medical materials. The preparation method comprises the following steps: dissolving polyvinyl alcohol, adding an acrylamide solution, by taking N,N'-methylene bisacrylamide as a crosslinking agent and nano titanium dioxide as a free radical initiator, firstly polymerizing acrylamide under ultraviolet light condition to form polyacrylamide network gel, then carrying out freeze-thraw cycle to form polyvinyl alcohol network gel, then carrying out oxidation crosslinking on the surface of a prefabricated hydrogel network by utilizing self-polymerization effect of dopamine, so that a polydopamine composite layer strongly adhered on the surface of a gel network is formed, and self-made nano hydroxy calcium phosphate is adsorbed, and the aim of further strengthening the hydrogel network is achieved. Meanwhile, the formed polydopamine surface layer and the adsorbed nano hydroxy calcium phosphate have good biocompatibility, and the problem that the traditional self-healing hydrogel is poor in mechanical strength and biocompatibility is effectively solved, so that the high-strength self-healing hydrogel has better application prospect.

Description

technical field [0001] The invention discloses a preparation method of high-strength self-healing hydrogel, which belongs to the technical field of medical material preparation. Background technique [0002] Polymer hydrogel is a macromolecule aggregate formed by covalent or non-covalent cross-linking, which can swell in water and maintain a certain shape. Hydrogel has excellent biocompatibility and similarity to biological tissue, and is playing an increasingly important role in biomedical materials such as drug controlled release, tissue engineering repair, biomimetic and other fields, and the development of self-healing The new multifunctional smart hydrogel will further expand its application. [0003] Self-healing materials have the characteristics of self-repairing damage, which can increase the safety of materials used and prolong the life of materials. They are intelligent new materials with damage management properties. Self-healing hydrogels based on dynamic chem...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C08L29/04C08L33/26C08L79/02C08K3/32C08J3/075C08J3/24A61L27/46A61L27/52A61L27/54
CPCC08L29/04A61L27/46A61L27/52A61L27/54A61L2300/406A61L2300/412A61L2400/06C08J3/075C08J3/246C08J2329/04C08J2433/26C08K2201/011C08L2201/06C08L2203/02C08L2205/03C08L33/26C08L79/02C08K2003/325
Inventor 许丽君孙冬林晨
Owner CHANGZHOU YAHUAN ENVIRONMENTAL PROTECTION TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap