Preparation method of high-strength self-healing hydrogel

Abstract

The invention discloses a preparation method of high-strength self-healing hydrogel and belongs to the technical field of preparation of medical materials. The preparation method comprises the following steps: dissolving polyvinyl alcohol, adding an acrylamide solution, by taking N,N'-methylene bisacrylamide as a crosslinking agent and nano titanium dioxide as a free radical initiator, firstly polymerizing acrylamide under ultraviolet light condition to form polyacrylamide network gel, then carrying out freeze-thraw cycle to form polyvinyl alcohol network gel, then carrying out oxidation crosslinking on the surface of a prefabricated hydrogel network by utilizing self-polymerization effect of dopamine, so that a polydopamine composite layer strongly adhered on the surface of a gel network is formed, and self-made nano hydroxy calcium phosphate is adsorbed, and the aim of further strengthening the hydrogel network is achieved. Meanwhile, the formed polydopamine surface layer and the adsorbed nano hydroxy calcium phosphate have good biocompatibility, and the problem that the traditional self-healing hydrogel is poor in mechanical strength and biocompatibility is effectively solved, so that the high-strength self-healing hydrogel has better application prospect.

Description

technical field [0001] The invention discloses a preparation method of high-strength self-healing hydrogel, which belongs to the technical field of medical material preparation. Background technique [0002] Polymer hydrogel is a macromolecule aggregate formed by covalent or non-covalent cross-linking, which can swell in water and maintain a certain shape. Hydrogel has excellent biocompatibility and similarity to biological tissue, and is playing an increasingly important role in biomedical materials such as drug controlled release, tissue engineering repair, biomimetic and other fields, and the development of self-healing The new multifunctional smart hydrogel will further expand its application. [0003] Self-healing materials have the characteristics of self-repairing damage, which can increase the safety of materials used and prolong the life of materials. They are intelligent new materials with damage management properties. Self-healing hydrogels based on dynamic chem...

AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention: Aiming at the problem that the traditional self-healing hydrogel has poor mechanical strength, short service life, and poor biocompatibility, which limits the scope of use of the self-healing hydrogel, a polymer based Vinyl alcohol and polyacrylamide are cross-linked, and the self-polymerization of dopamine is used to absorb self-made nano-hydroxy calcium phosphate to prepare a high-strength self-healing hydrogel. In the present invention, polyvinyl alcohol is first dissolved, and acrylamide solution is added to form N,N'-methylenebisacrylamide is used as a cross-linking agent, and nano-titanium dioxide is used as a free radical initiator. First, acrylamide is polymerized under ultraviolet light to form a polyacrylamide network gel, and then a polyacrylamide network gel is formed by freezing and thawing cycles. Vinyl alcohol network gel, then use the self-polymerization of dopamine to oxidize and cross-link the surface of the formed prefabricated hydrogel network to form a polydopamine composite layer strongly attached to the surface of the gel network, and adsorb self-made nano-hydroxy calcium phosphate, The purpose of further strengthening the hydrogel network is achieved, and the formed polydopamine surface layer and the adsorbed nano-calcium hydroxyphosphate have good biocompatibility, which effectively solves the problems of poor mechanical strength and biocompatibility of traditional self-healing hydrogels. good prospect