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Trimetazidine hydrochloride sustained release tablet and preparation method thereof

A technology of trimetazidine hydrochloride and sustained-release tablets, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, and medical preparations containing active ingredients, etc., which can solve the problems of pain relief, curative effect and clinical application limitations, heart disease, etc. Function damage and other problems, to achieve the effect of improving compliance, avoiding sudden release phenomenon, and stable quality

Inactive Publication Date: 2013-11-13
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the drugs for treating angina pectoris are mainly concentrated in nitrates, adrenergic β-receptor blockers and calcium channel antagonists, but they all exert myocardial protection through indirect effects such as improving the balance of oxygen supply and demand in the ischemic myocardium. And can only relieve the symptoms of angina pectoris
Most patients with angina have congestive heart insufficiency, chronic lung disease, or diabetes, and the effects of these drugs can further damage an already weakened heart
Therefore, its curative effect and clinical application are limited

Method used

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  • Trimetazidine hydrochloride sustained release tablet and preparation method thereof
  • Trimetazidine hydrochloride sustained release tablet and preparation method thereof
  • Trimetazidine hydrochloride sustained release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Prepare 1000 trimetazidine hydrochloride sustained-release tablets according to the prescription in the following table 1 and the above-mentioned preparation method.

[0033] Table 1 Prescription composition and dosage of trimetazidine hydrochloride sustained-release tablets (based on 1000 tablets)

[0034]

[0035] In the table, 8% povidone-80% ethanol-water solution obtains by following preparation method: be that in the ethanol aqueous solution of 80% that povidone is dissolved in mass concentration, the mass concentration that adjusts povidone is 8%, namely have to. Adhesives in the following examples were prepared using the same method.

Embodiment 2

[0037] Prepare 1000 trimetazidine hydrochloride sustained-release tablets according to the prescription in the following table 2 and the above-mentioned preparation method.

[0038] Table 2 Prescription composition and dosage of trimetazidine hydrochloride sustained-release tablets (based on 1000 tablets)

[0039]

Embodiment 3

[0041] Prepare 1000 trimetazidine hydrochloride sustained-release tablets according to the prescription in the following table 3 and the above-mentioned preparation method.

[0042] Table 3 Prescription composition and dosage of trimetazidine hydrochloride sustained-release tablets (based on 1000 tablets)

[0043]

[0044]

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Abstract

The invention discloses a trimetazidine hydrochloride sustained release tablet prepared from the following ingredients in percentage by weight: 10-25% of trimetazidine hydrochloride, 20-60% of hydrophilic gel skeleton material, 1-20% of a hydrophobic blocker, 15-55% of filler, 1-10% of a lubricant, 0 or 1-10% of a coating material and a proper dosage of adhesive. A wet granulation method is adopted in the preparation process. After the trimetazidine hydrochloride sustained release tablet disclosed by the invention touches water, the hydrophilic gel skeleton material can expand rapidly to form a gel layer with a plurality of pores, a drug can be slowly released through the pores, and the hydrophobic blocker can partially block the pores to avoid the burst release of the drug. Proper mass and proper proportion of hydrophilic gel skeleton material and hydrophobic blocker are added to realize slow and uniform release of the drug under the cooperation of the two ingredients and well avoid the burst release phenomenon so as to beneficially ensure the safety and effectiveness of drug therapy.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a trimetazidine hydrochloride sustained-release tablet and a preparation method thereof. Background technique [0002] Angina pectoris is a common cardiovascular disease, which is caused by coronary artery atherosclerosis and stenosis, coronary artery insufficiency, temporary myocardial ischemia and hypoxia, and a group of comprehensive symptoms with precordial pain as the main clinical manifestation. It is a kind of coronary heart disease with the highest incidence rate, which seriously threatens the health and life of human beings. It is mainly divided into stable angina and unstable angina. Angina pectoris can occur at any time in 24 hours, but most of them are from early morning to morning, and variant angina pectoris often occurs regularly at night. Therefore, it is required that the therapeutic drug can maintain an effective therapeutic concentration...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/36A61K31/495A61K47/38A61K47/12A61K47/14A61K47/32A61P9/10
Inventor 黄桂华冯瑞华
Owner SHANDONG UNIV
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