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Mesalazine enteric coatel tablet and preparation method thereof

A kind of mesalamine, the technology of extracting mesalamine, applied in the field of chemical medicine preparation, can solve the problems of low buffer release, high release in acid, insufficient curative effect, etc., to ensure hardness and friability, and increase stability , the effect of reducing losses

Active Publication Date: 2012-11-21
JIAMUSI LULING PHARMA CO LTD SUNFLOWER PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mesalazine enteric-coated tablets on the market and mesalazine enteric-coated preparations prepared by the prior art have solved the above problems well, but both have high release in acid, low release in buffer, insufficient curative effect, and poor product quality. Instability and other issues

Method used

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  • Mesalazine enteric coatel tablet and preparation method thereof
  • Mesalazine enteric coatel tablet and preparation method thereof
  • Mesalazine enteric coatel tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take 250g of mesalamine, 15g of calcium carbonate, 5g of talcum powder, and 2g of sodium carboxymethyl starch, mix them evenly, put them in a high-energy nano ball mill to make a nano-mixed powder of 100-300nm, put them in a coating granulator, add paste Essence 5g, mannitol 5g, mix well, use 10% povidone K30 ethanol solution as binder, make pellets, increase weight by 3%, get drug-containing pellets, put them in a fluidized coating machine, take LE enteric-coated Coating powder 18g, made into 10% ethanol solution, sprayed and coated to obtain enteric-coated pellets, added 15g of pregelatinized starch, 5g of pectin, 5g of microcrystalline cellulose, 5g of hydroxypropyl cellulose, and micronized silica gel 1g, mixed evenly, tableted to obtain tablet cores, placed in a film coating machine, 15g of LE enteric coating powder was taken, mixed with 8% ethanol liquid, sprayed and coated to obtain mesalazine enteric-coated tablets.

specific Embodiment 2

[0015] Take 250g of mesalamine, 25g of calcium carbonate, 15g of talcum powder, and 4g of sodium carboxymethyl starch, mix them evenly, put them in a high-energy nano ball mill to make a nano-mixed powder of 100-300nm, put them in a coating granulator, add paste Essence 15g, mannitol 15g, mix well, use 15% povidone K30 ethanol solution as binder, make pellets, increase weight by 5%, get drug-containing pellets, put them in a fluidized coating machine, take LE enteric-coated Coating powder 22g, made into 10% ethanol solution, sprayed and coated to obtain enteric-coated pellets, added 25g of pregelatinized starch, 15g of pectin, 15g of microcrystalline cellulose, 15g of hydroxypropyl cellulose, and micronized silica gel 3g, mixed evenly, tableted to obtain tablet cores, placed in a film coating machine, 25g of LE enteric coating powder was taken, mixed with 8% ethanol liquid, sprayed and coated to obtain mesalazine enteric-coated tablets.

specific Embodiment 3

[0017] Take 250g of mesalamine, 20g of calcium carbonate, 10g of talcum powder, and 3g of sodium carboxymethyl starch, mix them evenly, put them in a high-energy nano ball mill to make a nano-mixed powder of 100-300nm, put them in a coating granulator, add paste Essence 10g, mannitol 10g, mix well, use 12% povidone K30 ethanol solution as binder, make pellets, increase weight by 4%, get drug-containing pellets, put them in a fluidized coating machine, take LE enteric-coated Coating powder 20g, made into 10% ethanol solution, sprayed and coated to obtain enteric-coated pellets, added 20g of pregelatinized starch, 10g of pectin, 10g of microcrystalline cellulose, 10g of hydroxypropyl cellulose, and micronized silica gel 2g, mixed evenly, compressed to obtain tablet cores, placed in a film coating machine, 20g of LE enteric coating powder was taken, mixed with 8% ethanol liquid, sprayed and coated to obtain mesalazine enteric-coated tablets.

[0018] The raw material standards us...

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Abstract

The invention discloses a mesalazine enteric coatel tablet and a preparation method of the mesalazine enteric coatel tablet. The mesalazine enteric coatel tablet is characterized in that a nanotechnology, an enteric coating technology and a pellet tabletting technology are adopted to reduce the amount of release in the mesalazine enteric coatel tablet, increase the amount of release in a buffer solution, improve the curative effect, prolong the expiration date, guarantee the product quality, and obtain the promising result.

Description

technical field [0001] The invention relates to the field of chemical medicine preparation, in particular to a mesalazine enteric-coated tablet and a preparation method thereof. Background technique [0002] The chemical name of mesalamine is 5-aminosalicylic acid. It acts on the inflammatory mucosa, inhibits the synthesis of prostaglandins that cause inflammation and the formation of inflammatory mediator leukotrienes, and has a significant anti-inflammatory effect on intestinal wall inflammation. Excellent organizational effectiveness. This product should act locally, that is, when in contact with the large intestine mucosa, rather than after entering the blood circulation. Direct oral administration of mesalamine can be quickly absorbed by the stomach and small intestine, and can not reach the colon to play an anti-inflammatory effect. At the same time, the drug inhaled into the body is prone to toxicity. Intestinal absorption, making it localized to the terminal ileum ...

Claims

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Application Information

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IPC IPC(8): A61K31/606A61K9/36A61P1/04A61P29/00
Inventor 朱文军
Owner JIAMUSI LULING PHARMA CO LTD SUNFLOWER PHARMA GRP
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