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Mesalazine dripping pills and preparation method thereof

A technology for mesalazine and mesalazine dropping pills, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of low dissolution rate and dissolution rate, low bioavailability, long disintegration time, etc. , to achieve the effect of convenient administration, high bioavailability and improved drug stability

Inactive Publication Date: 2013-08-07
TIANJIN KANGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The currently commercially available mesalazine drop pills are tablets. Because the drug has a long disintegration time, low dissolution rate and dissolution rate, poor absorption and low bioavailability, it is not suitable for the elderly, bedridden patients and patients with dysphagia. It is inconvenient for patients to take, and the compliance is poor and the stability is not good

Method used

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  • Mesalazine dripping pills and preparation method thereof
  • Mesalazine dripping pills and preparation method thereof
  • Mesalazine dripping pills and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Prescription:

[0036]

[0037]

[0038] Preparation:

[0039] After mixing mesalazine, polyethylene glycol 4000 and polyethylene glycol 8000 evenly, heat it in a water bath to make it completely melted, pour the molten liquid into the material funnel of the dripping pill making machine, keep it warm at 80°C, select the drip tip, Drop it into simethicone oil at -5°C, and after it is shaped, filter, separate, and wipe clean to get it.

Embodiment 2

[0041] Prescription:

[0042]

[0043] Preparation:

[0044] Mix mesalazine, polyethylene glycol 1500, and polyethylene glycol 6000 evenly, heat in a water bath to make it melt completely, pour the molten liquid into the material funnel of the dripping machine, keep it warm at 80°C, and select the drip tip , drop into simethicone oil at -5°C, after forming, filter, separate, wipe clean, that is.

Embodiment 3

[0046] Prescription:

[0047]

[0048] Preparation:

[0049] Mix mesalazine, polyethylene glycol 1500, polyethylene glycol 4000, and poloxamer evenly, heat in a water bath to melt completely, pour the molten liquid into the material funnel of the dripping pill making machine, and heat at 80°C Keep warm, select the drip tip, drop into the simethicone oil at -5°C, after forming, filter, separate, wipe clean, and the product is ready.

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Abstract

The invention provides mesalazine dripping pills and a preparation method thereof. According to the invention, mesalazine and a substrate are combined according to a weight ratio of 1:1-100, such that the dripping pills are obtained. According to the invention, a mesalazine preparation form is changed from tablets unto dripping pills, such that the medicine is dispersed into the substrate in a state of molecules, colloid or microcrystalline. Medicine total surface area is increased. The substrate is hydrophilic, such that a wetting effect is provided for the medicine, and the medicine can be rapidly dispersed into micro-particles or solution. Therefore, medicine dissolving and absorption are accelerated, and bioavailability and medicine stability are improved. The dripping pills are highly efficient and convenient. Therefore, the mesalazine dripping pills provided by the invention has the advantages of accelerated dissolving and absorption, convenient application, high bioavailability and medicine stability, reduced adverse reaction, fast effect, convenient carrying, simple production process, and suitability for large-scale productions.

Description

technical field [0001] The invention relates to a medicine and the field of preparation thereof, in particular to a mesalazine dropping pill capable of treating inflammatory bowel disease and a preparation method thereof. Background technique [0002] Ulcerative colitis and Crohn's disease both belong to inflammatory bowel disease, referred to as IBD. Both diseases are characterized by recurrent intestinal ulcers. Patients often present with diarrhea, mucus bloody stools and abdominal pain, and the symptoms are very similar , The difference between the two is that Crohn's disease may affect various parts of the digestive tract, such as the esophagus, stomach, small intestine, and colon, while ulcerative colitis usually affects the large intestine. The most common lesion in Crohn's disease is in the ileocecal region, showing multiple and segmental ulcers; ulcerative colitis mainly involves the rectum and sigmoid colon, showing continuous lesions, and can also involve the enti...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/606A61P1/00A61P1/04
Inventor 解伟成
Owner TIANJIN KANGRUI PHARMA
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