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Lappaconitine gel patch and preparation method thereof

A technology of clathrate gel patch and high clathrate, which is applied in the directions of pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Poor performance, poor permeability and other problems, to achieve the effect of good compliance, reduce hydration, avoid allergies and irritation

Active Publication Date: 2016-11-09
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reported patches are all made of drugs and pressure-sensitive adhesives, and an appropriate amount of penetration enhancer is added. However, the pressure-sensitive adhesives have poor water absorption, resulting in poor skin compliance, poor air permeability, water permeability, and oxygen permeability. Time sticking will cause damage to the skin and other problems, and the high urine gel paste can overcome the above defects

Method used

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  • Lappaconitine gel patch and preparation method thereof
  • Lappaconitine gel patch and preparation method thereof
  • Lappaconitine gel patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Preparation:

[0041] Weigh the prescribed amount of uricine raw material, add it to Transcutol P, stir and sonicate for 30 minutes to make a geranin suspension for later use; add glycolic aluminum to glycerin, stir well and then add Viscomate NP -800, stir evenly, then add the homogenate suspension, stir evenly, then add PVPP, stir evenly, as phase A. Add carbomer and tartaric acid to distilled water to dissolve, then add azone and Tween 80, stir evenly, and use it as phase B. Add phase B to phase A, stir quickly to an appropriate viscosity, apply it with a coating machine, cut it into a suitable size, and pack it in an aluminum foil bag to obtain a gel plaster.

Embodiment 2

[0043] Preparation:

[0044] Weigh the raw material of urine in the prescribed amount, add it to polyethylene glycol-8-glycerol caprylic acid / capric acid ester, ethanol, stir and sonicate for 30 minutes to make a suspension of urine, and set aside; Add aluminum hydroxy to glycerin, stir well, then add Viscomate NP-800 and NP-700, stir well, then add homogenate suspension, stir well, then add micropowder silica gel, stir well, as phase A. Separately take PVA and tartaric acid and add them into distilled water to dissolve them, then add oleic acid, azone and polyoxyethylene castor oil, and stir evenly to form phase B. Add phase B to phase A, stir quickly to an appropriate viscosity, apply it with a coating machine, cut it into a suitable size, and pack it in an aluminum foil bag to obtain a gel plaster.

Embodiment 3

[0046] Preparation:

[0047] Weigh the prescribed amount of urinine raw material, add it to Pharmasolve and ethanol, stir and sonicate for 30 minutes to make a suspension of urinine for later use; take aluminum glyoxate and add it to glycerin, stir well and then add Viscomate NP-800, stir evenly, then add gaolin suspension, stir well, then add kaolin, stir well, as phase A. Separately take PVP K-90 and tartaric acid and add them into distilled water to dissolve, then add eucalyptus oil and Tween 80, stir evenly, and use it as phase B. Add phase B to phase A, stir quickly to an appropriate viscosity, apply it with a coating machine, cut it into a suitable size, and pack it in an aluminum foil bag to obtain a gel plaster.

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PUM

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Abstract

The invention relates to a lappaconitine gel patch and a preparation method thereof. The gel patch sequentially comprises a non-woven fabric layer, a patch matrix layer and a protective layer, wherein the patch matrix layer consists of the following components in parts by weight: 1.0-2.5 parts of lappaconitine, 5-12 parts of a cross-linked matrix, 0.2-0.4 parts of a cross-linking agent, 0.2-0.4 parts of a cross-linking regulator, 0.5-3 parts of a hydrophilic matrix, 0.5-3 parts of a filler, 20-35 parts of moisturizer, 0.5-3 parts of a transdermal promoter, 8-25 parts of a solubilizer and 25-55 parts of water. The gel patch prepared by the invention is high in drug loading amount, long in moisture content, strong in moisture retention, high in transdermal rate, long-acting, good in sustained-release effect and low in toxic and side effects, and the gel patch can dredge meridians and viscera, so as to take effects on a whole body; the gel patch is free from allergy or irritation and convenient to use; the gel patch cannot contaminate clothes and is unnecessary to pull hairs; and the gel patch can be repeatedly used and is low in production cost.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a gel plaster made of high quinone. Background technique [0002] Hoaconitine is an alkaloid extracted from the root of Aconitum aconitum of Ranunculaceae, also known as aconitine and lappaconitine (LA), which belongs to diterpene alkaloids. This product is the first non-addictive analgesic in my country. It is used to treat moderate pain, postoperative pain and intractable pain, especially cancer pain. The total effective rate can reach 90.82%. Non-addictive central nervous system analgesics prescribed in the Guiding Principles of Stepped Analgesic Therapy. The analgesic effect of this product is equivalent to that of morphine or pethidine (demerol), 7 times that of the antipyretic and analgesic drug aminopyrine, and has a long acting time, no addiction, long-term use will not cause physical dependence, no tramaline Various adverse reactions (such...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/439A61K47/18A61K47/10A61K47/34A61K47/32A61K47/02A61K47/04A61P29/00
CPCA61K9/7023A61K31/439A61K47/02A61K47/10A61K47/18A61K47/183A61K47/32
Inventor 楼炜俞婷婷沈腾方剑乔林咸明岳素荣李悦芦晓彤梁宜周杰
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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