23 results about "Pharmasolve" patented technology

The invention belongs to the technical field of medicines, and relates to a berberine tannate oral preparation and a preparation method thereof. The oral preparation comprises berberine tannate, a filling agent, a disintegrating agent, an adhesive and a wetting agent, the filling agent is pregelatinized starch, microcrystalline cellulose and colloidal silicon dioxide; the disintegrating agent is one or more of sodium carboxymethyl starch, cross-linked sodium carboxymethyl cellulose and cross-linked polyvinylpyrrolidone. The auxiliary materials of the berberine tannate oral preparation cooperate with one another, so that the flowability and compressibility of the powder are effectively improved, and the obtained final preparation product is excellent in stability and dissolution property and high in bioavailability; in addition, the oral preparation is simple in preparation process and suitable for large-scale production.

A bremelanotide pharmaceutical composition, a formulation thereof, a preparation method therefor, and use thereof. The bremelanotide pharmaceutical composition comprises bremelanotide as a pharmaceutically active ingredient, a solvent, and a polymer. The solvent includes one or more of N-methylpyrrolidone, polyethylene glycol, dimethyl sulfoxide, and benzyl benzoate and enables the plasma concentration of bremelanotide to be stably greater than 0.1 ng / mL at 120-168 h, thereby achieving the target sustained release. The bremelanotide pharmaceutical composition can be directly injected and does not require the addition of a thickener, a gel-forming agent, or other excipients.

This invention discloses a method for determining the encapsulation efficiency of amphotericin B liposomes for injection, comprising the following steps: separating the amphotericin B liposome solution for injection using solid-phase extraction adsorption to obtain an encapsulated drug solution and a free drug solution; and determining the drug mass concentration C in the encapsulated drug solution using HPLC. 包封 Drug mass concentration C in free drug solution 游离 And the total drug concentration C in the amphotericin B liposome solution before separation 总 The encapsulation efficiency and recovery rate of amphotericin B liposomes were calculated. This invention utilizes a macroporous copolymer of divinylbenzene and N-vinylpyrrolidone as the adsorbent in a solid-phase extraction adsorption method. Its macroporous structure provides ample adsorption sites while avoiding physical compression and damage to the liposome vesicles. This method achieves the separation of free amphotericin B liposomes from the encapsulated drug, exhibiting good reproducibility, high accuracy, simple operation, and high recovery rate.

The present invention provides a high-whiteness cross-linked polyvinylpyrrolidone and its preparation method and application, the preparation method comprises the following steps: cross-linked polyvinylpyrrolidone, water, Lewis acid and oxidant are mixed, reacted, and the high-whiteness cross-linked polyvinylpyrrolidone is obtained. Through the aqueous solution system, the oxidation of the oxidant is strengthened with Lewis acid, and the impurities such as N-vinylpyrrolidone, acetaldehyde and aldehyde condensation products adsorbed in the cross-linked polyvinylpyrrolidone are thoroughly oxidized and decomposed, fundamentally solving the problem of causing the cross-linked polyvinylpyrrolidone product to turn yellow; at the same time, cross-linked polyvinylpyrrolidone is further subjected to strong oxidation bleaching, so that the whiteness of the cross-linked polyvinylpyrrolidone product is significantly improved, and the whiteness value can reach 90%, and the preparation method will not additionally introduce impurities to affect the quality of the product, and the product can meet the requirements of the pharmacopoeia, and the process is simple, the process energy consumption is low, the cost is low, the pollution is low, and it is green and environmentally friendly.

The invention relates to a cosmetic composition comprising, in a physiologically acceptable medium, an oily phase and at least a) a phenyl silicone oil of formula (I) [Chem 1] (I) wherein—Me is methyl and Ph is phenyl, OR′ represents an —OSiMe3 group, —y ranges from 1 to 1000, and—z ranges from 1 to 1000, b) a C8-C30 fatty alcohol, c) a branched dextrin ester, and d) advantageously a liposoluble polymer selected from among the group consisting of: (i) acrylate polymers selected from among the group consisting of silicone acrylate polymers, acrylate polymers comprising an alkyl chain of at least 10 carbon atoms, and copolymers of acrylates and acrylamide, (ii) copolymers of vinylpyrrolidone (VP) and alkene comprising at least 18 carbon atoms, and (iii) mixtures thereof, and its use in particular on the lips for a make-up result with improved gloss and longer-lasting gloss and color. Preferably, the composition is in a semi-solid or solid form.

A high-whiteness cross-linked povidone, a preparation method therefor and a use thereof. The preparation method comprises the following steps: mixing cross-linked povidone, water, a Lewis acid and an oxidizing agent, and reacting to obtain the high-whiteness cross-linked povidone. By means of an aqueous solution system, the Lewis acid is used to enhance the oxidation effect of the oxidizing agent, so as to implement thorough oxidative decomposition of impurities such as N-vinyl pyrrolidone, acetaldehyde and aldehyde condensates adsorbed in the cross-linked povidone, so that the problem of yellowing of a cross-linked povidone product is fundamentally solved; in addition, the cross-linked povidone is further subjected to strong oxidation bleaching, so that the whiteness of the cross-linked povidone product is remarkably improved, and the whiteness value can reach 90%; and according to the preparation method, the quality of the product will not be affected due to additional introduction of impurities, the product can meet the requirements of pharmacopoeia, the process is simple, the process energy consumption is low, the cost is low, less pollution is produced, and the method is environmentally-friendly.

The present invention belongs to the field of biopharmaceuticals and provides a κ-opioid receptor agonist having the following formula, its stereoisomers, and pharmaceutically acceptable salts thereof. The κ-opioid receptor agonist has high selectivity for the κ-opioid receptor, its activity is 3 to 15 times that of diferikephalin, and has high pharmacological activity, and can be used for the treatment, prevention and / or remission of pruritus, and / or analgesia. D-Phe-AA1-AA2-D-Lys-4-aminopiperidine-4-carboxamide-AA3-AA4-AA5 [Formula I].

The invention relates to the technical field of pharmaceutical preparations, and particularly provides a brexpiprazole sustained-release injection based on in-situ phase change gel as well as a preparation method and application of the brexpiprazole sustained-release injection. The brexpiprazole sustained-release injection is prepared from brexpiprazole, N-methyl pyrrolidone and a polylactic acid-glycolic acid copolymer according to the weight ratio of (0.1 to 0.2): (3 to 3.8): 1, wherein the intrinsic viscosity of the polylactic acid-glycolic acid copolymer is (0.1 to 0.3) dL / g. The preparation process of the brexpiprazole sustained-release injection is relatively simple and convenient, and the brexpiprazole sustained-release injection is a homogeneous solution before injection, so that the injection tolerance of a patient is effectively improved; the inherent problems that brexpiprazole is extremely high in hydrophobicity, rapid in-vivo elimination and free of remarkable central activity of metabolites are solved, stable slow release of blood concentration for several weeks is achieved, the drug release kinetics is highly predictable and good in reproducibility, and the purposes of reducing the drug administration frequency and improving the patient compliance are achieved.

The present invention belongs to the technical field of medicine. Disclosed are a microneedle composition containing semaglutide, and a preparation method therefor and the use thereof. The microneedle composition containing semaglutide consists of a needle body and a substrate, wherein the components of the needle body comprise semaglutide, a cosolvent, and an excipient; the cosolvent is selected from one or more of Tween, Span, propylene glycol, glycerol, and lecithin; and the excipient is selected from one or more of dextran, polyvinylpyrrolidone, hyaluronic acid, and water-soluble cyclodextrin. A soluble microneedle is prepared from semaglutide and the microneedle excipient, which has sufficient mechanical strength to pierce the skin, thereby achieving transdermal delivery of a macromolecular polypeptide drug. Moreover, in a pharmacokinetic experiment, the microneedle composition can simultaneously achieve a maximum plasma concentration with an injection dosage form, and the relative bioavailability can be improved by 40-60 times compared with that of an oral dosage form. The microneedle composition is present in a solid form, thus significantly improving the stability of semaglutide and substantially reducing the cost requirements for storage.

To provide a pharmaceutical composition for enhancing the expression of the insulin-like growth factor 2 gene and a food composition for enhancing the expression of the insulin-like growth factor 2 gene.SOLUTION: The present invention provides a pharmaceutical composition for enhancing the expression of the insulin-like growth factor 2 gene and a food composition for enhancing the expression of the insulin-like growth factor 2 gene, containing 5-acetyl-1-benzylpyrrolidine-2-one as an active ingredient.SELECTED DRAWING: None

Pharmaceutical formulations are provided that include a 4-((2-hydroxy-3-methoxybenzyl)amino)-benzenesulfonamide 12-LOX inhibitor with improved solubility for oral administration. Also provided are pharmaceutical formulations that include a selective 12-LOX inhibitor amorphously dispersed in a material selected from vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64), aminomethyl acrylate copolymer (Eudragit EPO), hydroxypropyl methylcellulose E3 (HPMC E3), or a combination thereof, and have a high drug load of 30% or more, comprising 40-80% of the total solid content of the formulation. Alternatively, the formulations contain additives, such as surfactants (sodium lauryl sulfate), crystallization inhibitors, or pH adjusters, in an amount of up to 20% of the total solid content of the formulation.

The present disclosure provides compositions, systems, pre-filled delivery devices, and methods for developing injectable compositions useful for in situ forming solid depots for the sustained release of non-steroidal anti-inflammatory drug NSAIDs over a period of days to several months for use in treating or preventing inflammation. The compositions comprise a biodegradable polymer such as poly(lactic-co-glycolic acid) (PLGA), a solvent such as N-Methyl-2-pyrrolidone, and a NSAID such as naproxen, meloxicam. The compositions may optionally comprise an additive such as hydrogenated soy L-α-phosphatidylcholine (HSPC) or a second active agent. The depot material will be robust to exist within the desired site for a period similar to or greater than the planned period of drug delivery.

This invention belongs to the field of pharmaceutical formulation technology, specifically relating to a solid dispersion of acetosalis flavonoids, a solid dosage form, and a preparation method thereof. The raw materials for the solid dispersion include acetosalis flavonoids, a homopolymer of N-vinylpyrrolidone, and inulin, wherein the N-vinylpyrrolidone homopolymer is povidone K30. The acetosalis flavonoid solid dosage form of this invention achieves a cumulative dissolution rate of over 90% within 30 minutes; the preparation process is simple, does not use any organic solvents, and exhibits very rapid dissolution.

To provide a pharmaceutical composition for enhancing the expression of the WD and tetratricopeptide repeats 1 gene and a food composition for enhancing the expression of the WD and tetratricopeptide repeats 1 gene.SOLUTION: The present invention provides a pharmaceutical composition for enhancing the expression of the WD and tetratricopeptide repeats 1 gene and a food composition for enhancing the expression of the WD and tetratricopeptide repeats 1 gene, containing 5-acetyl-1-benzylpyrrolidine-2-one as an active ingredient.SELECTED DRAWING: None

The present invention provides pharmaceutical formulations comprising a 4-((2-hydroxy-3-methoxybenzyl) amino)-benzenesulfonamide 12-LOX inhibitor, which have improved solubility, and are useful for oral administration. Also provided are pharmaceutical formulations comprising a selective 12-LOX inhibitor having a high drug loading of 30% or more, dispersed amorphous in a composition selected from the group consisting of a vinyl pyrrolidone-vinyl acetate copolymer (Kollidon VA64), an aminomethacrylate copolymer (Eudragit EPO), hydroxypropyl methyl cellulose E3 (HPMC E3), or a combination thereof, and from 40% to 80% of the total solids content of the formulation. The formulation also contains an additive, such as a surfactant (lauryl sodium sulfate), a crystal inhibitor or a pH regulator, which accounts for up to 20% of the total solids content of the formulation.

The present invention aims to provide an injectable pharmaceutical composition containing diferikephalin that can reduce human error and labor associated with dosage preparation in medical settings. [Solution] The present invention relates to an injectable pharmaceutical composition containing diferikephalin or a pharmacoagulably acceptable salt thereof for the treatment of pruritus in dialysis patients, wherein the injectable pharmaceutical composition is designed to reduce human error and labor associated with dosage preparation in medical settings, and the injectable pharmaceutical composition contains diferikephalin or a pharmacoagulably acceptable salt thereof in amounts of 17.5 μg, 25.0 μg, 35.0 μg, or 42.5 μg in free form equivalent, and relates to an injectable pharmaceutical composition for administration to dialysis patients with a dry weight of less than 45 kg, 45 kg or more but less than 65 kg, 65 kg or more but less than 85 kg, or 85 kg or more, respectively.

The invention relates to the technical field of daily chemical products, and discloses a scalp micro-ecological repair aerosol. The scalp micro-ecological repair aerosol is prepared from the following effective components in parts by weight: 5 to 10 parts of emulsified castor oil, 1 to 2 parts of L-sodium pyrrolidone carboxylate, 0.5 to 1.0 part of rhizoma chuanxiong extract, 0.5 to 1.0 part of tea seed oil, 0.3 to 0.5 part of composite micro-film aid, 0.1 to 0.2 part of sodium hyaluronate, 0.1 to 0.2 part of beta-glucan, 0.1 to 0.2 part of alpha-glucan oligosaccharide, 0.05 to 0.1 part of isopropyl myristate and 0.05 to 0.1 part of DL-panthenol, the invention discloses a chamomile essence which is prepared from the following raw materials in parts by weight: 0.05-0.1 part of chamomile extract, 0.05-0.1 part of an emulsifier, 0.01-0.05 part of phospholipid, 0.01-0.03 part of capryloyl glycine, 0.005-0.01 part of 2-alpha glycerol glucoside, 85-90 parts of deionized water, a proper amount of an odorant and a proper amount of lactic acid serving as a pH regulator. According to the invention, polyethylene glycol and frankincense are used as a micro-film auxiliary agent and cooperate with a plurality of compositions, so that the obtained aerosol can significantly improve the scalp micro-ecological environment and balance scalp microbiota.

The present invention discloses a composition, a nasal spray for treating Parkinson's disease and a preparation method thereof. The composition is composed of levodopa and epigallocatechin gallate in a mass ratio of 1-3:1. The nasal spray for treating Parkinson's disease is prepared from the following components in weight percentages: 54-72% of glyceryl monooleate, 18-36% of N-methylpyrrolidone, 1.4-2.1% of levodopa, 0.7-1.4% of epigallocatechin gallate 、 Water is added to 100%. The composition can significantly improve the stability of levodopa and synergistically improve its therapeutic effect on Parkinson's disease; the nasal spray can improve the olfactory region deposition rate of the drug, improve its nasal-brain delivery efficiency, and thus improve its therapeutic effect on Parkinson's disease.

The invention discloses a novel long-acting preparation and a preparation method thereof, belongs to the field of pharmaceutical preparations, and finds that a certain amount of glyceryl monolinoleate (GMLO) and soybean lecithin (SPC) can be fully and uniformly mixed in a certain amount of ethanol (ETOH) or N-methyl pyrrolidone (NMP) to form a clear liquid with good fluidity, and the liquid has a good effect on hydrophobic drugs ZL006-05 (code name Y-3, code name Y-3, code name Y-3, code name Y-3, code name Y-3, code name Y-3, code name Y-3, code name Y-3, code name Y-3, code name Y-3, code name Y-3, code name Y-3, code name Y-3, code name Y-3, code name The compound has a good dissolving effect. The formula (1) is shown in the description. When the liquid preparation is exposed to a water-containing component such as body fluid, gel is formed, so that a long-acting drug release effect is achieved. The liquid preparation can also be used for slow-release carriers of drugs with other properties. The invention also relates to a delivery method using the liquid formulation.

Formulations with enhanced SN-38 solubility and oral absorption. In one embodiment, a formulation or a pharmaceutical composition comprises (a) 7-Ethyl-10-hydroxy-camptothecin (SN-38); and (b) a mixture of pharmaceutically acceptable excipients comprising (i) N-Methylpyrrolidone; and (ii) Vitamin E TPGS or a copolymer, the copolymer being 50 / 50 poly(lactic-co-glycolic acid), or 75 / 25 poly(lactic-co-glycolic acid) (PLGA); with the provision that if the VitE TPGS is present, the mixture of the excipients further comprises a polymer selected from the group consisting of Hydroxypropyl cellulose, Hydroxypropyl methylcellulose, VP / VAc copolymer 60 / 40, poloxamer 407, and Lauroyl Macrogol-32 glycerides; wherein the pharmaceutical composition contains no water, is in a liquid or a gel form, and the SN-38 is dissolved in the mixture of the excipients without precipitation.

The invention discloses an alkannin nasal spray film agent for repairing nasal mucosa lesion. The alkannin nasal spray film agent comprises 10 mg of L-alkannin; 1.5 g to 3 g of propylene glycol; 6 to 9 g of polyvinylpyrrolidone K30; 0.1 g to 0.4 g of methyl cellulose (MC); 80 [mu] l to 120 [mu] l of a solubilizer; 0.02 g to 0.08 g of a preservative; the solvent is a low-degree ethanol solution, and the mass fraction of the low-degree ethanol solution is 28-32%. The invention also discloses a preparation method of the film spraying agent. The shikonin film spraying agent can reduce the expression of proinflammatory factors, alleviate local inflammatory response and promote tissue remodeling by reducing the levels of inflammatory factors and chemotactic factors, and can generate a good treatment effect on nasal mucosa repair.

The invention belongs to the technical field of cosmetics and skin medicine preparations, and particularly relates to a hydrogel composition containing elaeagnus conferta roxb, a preparation method of the hydrogel composition and a network pharmacology analysis and evaluation method. The composition is prepared from the following components: 1.5 to 2.5 percent w / v of sodium alginate, 0.5 to 1.5 percent w / v of hyaluronic acid, 4 to 6 percent w / v of glycerol, 0.2 to 0.3 percent w / v of ceramide, 0.4 to 0.6 percent w / v of glycyrrhizic acid, 0.05 to 0.15 percent w / v of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.2 to 0.3 percent w / v of sodium pyrrolidone carboxylate, 0.2 to 0.3 percent w / v of allantoin, 0.4 to 0.6 percent w / v of adenosine triphosphate and 0.5 to 5 percent w / v of elaeagnus conferta roxb extract. The invention systematically overcomes the technical resistance of unknown components, fuzzy mechanism, low dosage form efficiency and disjoint verification of the natural extract in the treatment of the specific dermatitis from the whole chain innovation of component analysis, mechanism verification, dosage form design and evaluation system.