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Orally disintegrating tablet of 'Baibaodan' and its preparation

A technology of orally disintegrating tablets and Biobolan, which is applied in the direction of medical formula, medical preparations containing active ingredients, pill delivery, etc., can solve the problem of increasing the dosage of patients, not extracting and purifying, and not searching for the oral cavity of Biobolan Disintegrating tablet patent information and other issues

Inactive Publication Date: 2005-03-16
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Standard No. WS-11350 (ZD-1350)-2002 records the standard of Baibaodan Capsules. This standard simply crushes the four traditional Chinese medicines and puts them into capsules to prepare Baibaodan Capsules. This method does not apply to each Extraction and purification of flavored traditional Chinese medicines increased the dosage of patients; no patent information about Baibaodan orally disintegrating tablets was retrieved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] (1) bulk drug of the present invention consists of:

[0120] Notoginseng 7.5 grams, Diancaowu (made) 80 grams, Chonglou 62.5 grams, Jintie Suo 100 grams;

[0121] (2) Take notoginseng decoction pieces and crush them, pass through a 10-mesh sieve, take the crushed notoginseng, add 5 times the amount of 60% ethanol to extract twice, each time for 2 hours, filter, recover the ethanol from the filtrate to the end, concentrate and dry in vacuo Obtain 0.7 grams of the effective part of Panax notoginseng;

[0122] (3) Take the decoction pieces of Diancaowu (made), crush them, add water to soak for 0.5 hours, add 10 times more water to decoct twice, each time for 1 hour, filter, combine the filtrates, and when the filtrates are concentrated to 50°C, the relative density is 1.05 , put on the AB-8 type macroporous adsorption resin column, elute with 6 times of water, discard the washing liquid, and then elute with 8 times of 75% ethanol, combine the eluents, recover ethanol to t...

Embodiment 2

[0128] (1) bulk drug of the present invention consists of:

[0129] Notoginseng 7.5 grams, Diancaowu (made) 80 grams, Chonglou 62.5 grams, Jintie Suo 100 grams;

[0130] (2) Take notoginseng decoction pieces and crush them, pass through a 15-mesh sieve, take the crushed notoginseng, add 8 times the amount of 80% ethanol to extract 4 times, each time for 4 hours, filter, recover the ethanol from the filtrate to the end, concentrate and dry in vacuo Obtain 1.5 grams of the effective part of Panax notoginseng;

[0131] (3) Take the decoction pieces of Aconitum yunnanensis (made), crush them, soak in water for 1 hour, add 20 times more water to decoct twice, each time for 2 hours, filter, combine the filtrates, and the relative density of the filtrates is 1.10 when concentrated to 50°C , put on the AB-8 type macroporous adsorption resin column, elute with 8 times of water, discard the washing liquid, and then elute with 10 times of 85% ethanol, combine the eluents, recover the et...

Embodiment 3

[0137] (1) bulk drug of the present invention consists of:

[0138] Notoginseng 7.5 grams, Diancaowu (made) 80 grams, Chonglou 62.5 grams, Jintie Suo 100 grams;

[0139] (2) Take notoginseng decoction pieces and crush them, pass through a 10-mesh sieve, take the crushed notoginseng, add 6 times the amount of 65% ethanol to extract 3 times, each time for 3 hours, filter, recover the ethanol from the filtrate to the end, concentrate and dry in vacuo Obtain 0.8 grams of the effective part of Panax notoginseng;

[0140] (3) Take the decoction pieces of Diancaowu (made), crush them, soak in water for 0.6 hours, add 12 times of water to decoct twice for 1.5 hours each time, filter, and combine the filtrates. When the filtrates are concentrated to 50°C, the relative density is 1.06 , put on the AB-8 type macroporous adsorption resin column, elute with 7 times of water, discard the washing liquid, and then elute with 9 times of 80% ethanol, combine the eluents, recover the ethanol to...

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PUM

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Abstract

The invention discloses an orally disintegrating tablet of 'Baibaodan'and its preparation, characterized in that the tablet comprises the significant portions extracted from traditional Chinese medicinal pseudo-ginseng, preserved Yunnan Kusnezoff monkshood root, Psammosilene tunicoides and other medical use findings, the invention is also characterized that composite disintegrating tablet containing tetrahydroxy butane is employed, wherein the composite disintegrating tablet is obtained by combining tetrahydroxy butane with low substituted Hydroxypropylmethyl cellulose or sodium carboxymethylstarch or crossbond sodium carboxymethylstarch or insoluble cross bond polyvinylpyrrolidone by a finite proportion, the tetrahydroxy butane has the action of taste rectifying agent, thus reducing the consumption of medicinal findings in the preparation. Pharmacological experiment has shown that the disintegrating tablet has the advantages of quick disintegration, fast effect, and better pharmacological actions.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to an orally disintegrating tablet of Bibaodan and a preparation method thereof. Background technique [0002] Orally disintegrating tablets are a new pharmaceutical preparation, which can be absorbed through the sublingual mucosa and directly enter the blood, effectively avoiding the first-pass effect, so the dosage is small, safe and has a rapid effect. Although it is an oral preparation, it can achieve the effect of an injection preparation. Therefore, it is gradually becoming a hot spot in the field of pharmaceutical companies and research and development. The dosage form is mainly to select a suitable fast disintegrating agent, and the tablet made of it has a certain hardness and a certain degree of porosity. When taking it, it does not need water to assist swallowing, and it can quickly disintegrate into fine particles in the mouth, ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61P43/00
Inventor 张晴龙
Owner 张晴龙
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