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Orally disintegrating tablet of gingko leaf and its preparation process

An orally disintegrating tablet and ginkgo biloba technology are applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., which can solve problems such as poor stability of orally disintegrating tablets, and achieve good pharmacological effects, rapid and stable curative effects. good effect

Inactive Publication Date: 2005-03-16
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has a miraculous effect on the treatment of coronary heart disease, angina pectoris, cerebral arteriosclerosis, senile dementia, high blood pressure and other diseases. Therefore, pharmaceutical preparations made of ginkgo biloba are widely used in clinical practice, but most of them are solid preparations such as tablets and capsules or Injection preparations for long-term treatment; refer to the patent report on ginkgo biloba orally disintegrating tablets in the literature. Although the disintegrant has good disintegration performance, it has good hygroscopicity, and the prepared orally disintegrating tablet has poor stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] (1) The raw material drug prescription of the present invention is:

[0116] Ginkgo biloba 1750 grams;

[0117] (2) Get ginkgo leaf and extract 2 times with 70% ethanol backflow, each time 2 hours, filter, and filtrate reclaims ethanol to the utmost, when concentrated to 20 ℃, relative density is the clear cream of 1.20-1.25, spray drying, obtains ginkgo leaf The active part is 105 grams;

[0118] (3) Get 105 grams of Ginkgo biloba effective parts and mix with 86 grams of disintegrating agent of the present invention, add filler microcrystalline cellulose 204 grams, granulate, add lubricant magnesium stearate 5 grams, tabletting, obtain Ginkgo biloba 1000 disintegrating tablets.

[0119] The compound disintegrant is composed of erythritol and chitin or low-substituted hydroxypropylmethylcellulose or sodium carboxymethyl starch or cross-linked sodium carboxymethyl starch or insoluble cross-linked polyvinylpyrrolidone, the ratio of which is 3- 7:7-3, that is, the weigh...

Embodiment 2

[0121] (1) The raw material drug prescription of the present invention is:

[0122] Ginkgo biloba 1750 grams;

[0123] (2) Get ginkgo leaf and extract 2 times with 70% ethanol backflow, each time 2 hours, filter, and filtrate reclaims ethanol to the utmost, when concentrated to 20 ℃, relative density is the clear cream of 1.20-1.25, spray drying, obtains ginkgo leaf Effective part 210 grams;

[0124] (3) Get 210 grams of effective parts of Ginkgo biloba and mix with 57 grams of disintegrating agent of the present invention, add 125 grams of filler nano-microcrystalline cellulose, granulate, add 8 grams of lubricant talcum powder, compress tablets, and obtain Ginkgo biloba disintegrating Decompose 1000 tablets.

[0125] The compound disintegrant is composed of erythritol and chitin or low-substituted hydroxypropylmethylcellulose or sodium carboxymethyl starch or cross-linked sodium carboxymethyl starch or insoluble cross-linked polyvinylpyrrolidone, the ratio of which is 3- ...

Embodiment 3

[0127] (1) The raw material drug prescription of the present invention is:

[0128] Ginkgo biloba 1750 grams;

[0129] (2) Get ginkgo leaf and extract 2 times with 70% ethanol backflow, each time 2 hours, filter, and filtrate reclaims ethanol to the utmost, when concentrated to 20 ℃, relative density is the clear cream of 1.20-1.25, spray drying, obtains ginkgo leaf The active part is 129 grams;

[0130] (3) Get 129 grams of ginkgo biloba effective parts and mix with 81 grams of disintegrating agent of the present invention, add filler microcrystalline cellulose 184 grams, granulate, add lubricant magnesium lauryl sulfate 6 grams, tabletting, obtain Ginkgo biloba disintegrating tablets 1000 tablets.

[0131] The compound disintegrant is composed of erythritol and chitin or low-substituted hydroxypropylmethylcellulose or sodium carboxymethyl starch or cross-linked sodium carboxymethyl starch or insoluble cross-linked polyvinylpyrrolidone, the ratio of which is 3- 7:7-3, that...

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PUM

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Abstract

The invention discloses an orally disintegrating tablet of gingko leaf and its preparation process, characterized in that the tablet comprises the significant portions extracted from traditional Chinese medicinal ginkgo leaves and other medical use findings, the invention is also characterized that composite disintegrating tablet containing tetrahydroxy butane is employed, wherein the composite disintegrating tablet is obtained by combining tetrahydroxy butane with low substituted Hydroxypropylmethyl cellulose or sodium carboxymethylstarch or crossbond sodium carboxymethylstarch or insoluble cross bond polyvinylpyrrolidone by a finite proportion, the tetrahydroxy butane has the action of taste rectifying agent, thus reducing the consumption of medicinal findings in the preparation. Pharmacological experiment has shown that the disintegrating tablet has the advantages of quick disintegration, fast effect, and better pharmacological actions.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a ginkgo leaf orally disintegrating tablet and a preparation method thereof. Background technique [0002] Orally disintegrating tablets are a new pharmaceutical preparation, which can be absorbed through the sublingual mucosa and directly enter the blood, effectively avoiding the first-pass effect, so the dosage is small, safe and has a rapid effect. Although it is an oral preparation, it can achieve the effect of an injection preparation. Therefore, it is gradually becoming a hot spot in the field of pharmaceutical companies and research and development. The dosage form is mainly to select a suitable fast disintegrating agent, and the tablet made of it has a certain hardness and a certain degree of porosity. When taking it, it does not need water to assist swallowing, and it can quickly disintegrate into fine particles in the mouth, a...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61P9/00
Inventor 张晴龙
Owner 张晴龙
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