Mixture of new capable of degradation totally bone inside fixed polymer and cross-linking method

A cross-linking method and technology of cross-linking agent, which are applied in medical science, prosthesis, surgery, etc., can solve the problems of high cost and low mechanical strength, and achieve the effect of low production cost and high mechanical strength.

Inactive Publication Date: 2008-06-18
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For the defects of high cost and low mechanical strength of existing bone internal fixation materials

Method used

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  • Mixture of new capable of degradation totally bone inside fixed polymer and cross-linking method
  • Mixture of new capable of degradation totally bone inside fixed polymer and cross-linking method
  • Mixture of new capable of degradation totally bone inside fixed polymer and cross-linking method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: Synthesis of unsaturated polyester amide

[0041] Under nitrogen protection, add 0.024mol (3.59g) of phthalic anhydride, 0.046mol (3.49g) of propylene glycol, and 0.049mol (5.09g) of neopentyl glycol into a three-necked flask with a magnetic stirrer and an oil-water separator, and stir under strong magnetic force. Raise the temperature of the system to 160°C for 1 hour, cool to 120°C and add 0.076mol (7.42g) of maleic anhydride and 0.0125mol (0.937g) of glycine to react for 1 hour, then raise the temperature to 180°C for 1 hour, then Polycondensation reaction at 195°C for 4 hours, then lower the reaction temperature to 120°C, add 10% cyclohexanol to react for 1 hour, raise the temperature to 160°C for 1 hour, then raise the temperature to 180°C for 1 hour. After the temperature drops to 100°C, it is taken out, and a light brown transparent viscous unsaturated polyester amide is obtained after cooling.

Embodiment 2

[0042] Example 2: Crosslinking of unsaturated polyester amides

[0043] Dissolve 0.06g of benzoyl peroxide in 2g of vinyl acetate, add vinyl acetate in which benzoyl peroxide has been dissolved in 8g of synthesized unsaturated polyester amide and stir evenly, then add 0.002g of N, N - Dimethylaniline is used as an accelerator, fully miscible and then poured into the pre-prepared polytetrafluoroethylene mold for cross-linking at room temperature. After a certain period of time, take out the cross-linked sample and heat-treat it in an oven at 100°C for 1 hour, then lower the temperature Heat treatment at 195°C for 22 hours.

Embodiment 3

[0044] Example 3: Crosslinking of unsaturated polyester amides

[0045] Dissolve 0.06g of benzoyl peroxide in 3g of vinyl acetate, add benzoyl peroxide-dissolved vinyl acetate into 7g of synthetic unsaturated polyester amide and stir evenly, then add 0.002g of N, N - Dimethylaniline is used as an accelerator, fully miscible and then poured into the pre-prepared polytetrafluoroethylene mold for cross-linking at room temperature. After a certain period of time, take out the cross-linked sample and heat-treat it in an oven at 100°C for 1 hour, then lower the temperature Heat treatment at 195°C for 22 hours.

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Abstract

Disclosed is a novel synthesis and cross-linking method which can completely degrading intraosseous fixed polymer. The invention adopts 1, 2-propylene glycol (or ethylene glycol ), dineopentyl alcohol neopentyl glycol, maleic anhydride, phthalic anhydride, glycin (or caprolactam) and cyclohexanol as raw material to synthesize an adjustable, innocuous, low-cost unsaturated polyesteramide, by a method of melt phase polycondensation and molecular chain end capping. By adding an amount of crosslinking agent (vinyl acetate or vinyl pyrrolidone) and initiating heat treatment after the accelerant crosslinking at room temperature, the completely degradable intraosseous fixed material with high strength can be produced. The unsaturated polyesteramide can also be developed into completely-degradable disposable tablewares, packing materials, flowerpots, medical supplies, drug-coating or basis materials such as delayed (controlled) release materials for capsules and drugs, glass fiber reinforced plastics etc.

Description

technical field [0001] The present invention relates to the use of unsaturated dibasic acid (anhydride), glycine (or caprolactam), and dioxanol copolymerization with cyclohexanol capping, and then adding a certain amount of cross-linking agent and initiator-promoter room temperature cross-linking and A new type of fully biodegradable bone internal fixation material is prepared by heat treatment and deep cross-linking. technical background [0002] Internal bone fixation (including the treatment of traumatic fractures or bone deformity orthopedic osteotomy) is one of the most commonly used treatment methods in clinical medicine. Although the current clinically used biostable metal internal fixation can complete the early strong fixation of the fracture, but because its elastic modulus is too high (20-30 times that of human bone), the mechanical properties cannot change dynamically with the bone healing process, resulting in local fractures. Produces stress shielding effect, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L31/06C08L77/12
Inventor 石宗利艾永平郭文迅
Owner HUNAN UNIV
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