Cerebral apoplexy treating effervescence tablet and its preparation method

A technology for effervescent tablets and cerebral thrombosis, which is applied in the field of cerebral thrombosis effervescent tablets and its preparation, and can solve the problems of large dosage, low bioavailability, incomplete drug absorption and the like

Inactive Publication Date: 2005-11-23
ZHEJIANG HISUN PHARMA CO LTD +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, although the original dosage form has the effects of antithrombotic and blood vessel expansion, but because the four ingredients such as Radix Paeoniae Rubra are directly compressed into tablets with crude drug fine powder, there are disadvantages such as low bioavailability, incomplete drug absorption and large dosage.

Method used

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  • Cerebral apoplexy treating effervescence tablet and its preparation method

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Experimental program
Comparison scheme
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Embodiment 1

[0073] Embodiment 1. The research of extraction volatile oil technology such as angelica, Rhizoma Chuanxiong

[0074] Angelica, Chuanxiong, and peach kernels are rich in volatile oil. If they are fried together with other ingredients, their extraction may be affected, while traditional Chinese medicine compound preparations emphasize synergistic effects. Combined decoction and oil extraction for comparison. With the yield of volatile oil as the main index and the active ingredients of each herbal medicine as the auxiliary index, the orthogonal design was carried out, and the best processes obtained were compared to determine the oil extraction scheme.

[0075] 1.1 Orthogonal design experiment of decocting and extracting oil with three herbs

[0076] Orthogonal experiment method was used to determine the optimal extraction conditions of the volatile oil of Angelica sinensis, Chuanxiong and Taoren. Three factors were selected as the investigation factors: the fineness of medici...

Embodiment 2

[0149] Example 2. Research on optimal process screening of volatile oil inclusion

[0150] The volatile oil proposed by the mixed medicine has a strong pungent smell. If it is directly used as medicine, it is not conducive to direct taking, and it is easy to volatilize and difficult to store, so it is difficult to control the quality of the preparation. For example, after inclusion as a molecule, the solubility increases and the stability improves, and the liquid volatile oil can be powdered to prevent its volatilization, while covering up bad smell or taste, reducing irritation and side effects. β-CD (β-cyclodextrin, the same below) is used as the inclusion material, which has a good inclusion effect on the volatile oil of traditional Chinese medicine. The inclusion methods and conditions were investigated as follows.

[0151] 2.1 Screening of inclusion methods

[0152] There are several methods for inclusion of volatile oil: ①Electric constant temperature stirring method; ...

Embodiment 3

[0205] Embodiment 3. Research on the impurity removal process of water extracts such as Angelica sinensis

[0206] Alcohol precipitation treatment or natural clarifier treatment was selected, and the two impurity removal methods were compared with the raw liquid of the mixed medicinal material water extract to select a better impurity removal method.

[0207] 3.1 Alcohol precipitation and impurity removal process

[0208] When using ethanol to remove impurities, it is better to use 60% ethanol (V / V) for the aqueous extracts of Chuanxiong and Angelica, and 60-70% (V / V) ethanol for red peony and salvia. Well, then preferably 60% (V / V) is used as ethanol precipitation concentration.

[0209] Take the water extract after extracting oil from the five flavors of Rhizoma Chuanxiong, Angelica, Radix Paeoniae Rubra, Salvia miltiorrhiza, and peach kernel, concentrate in vacuo at 60°C in the dark to a density of 1.02, add 95% ethanol (V / V) for alcohol precipitation, and make the concent...

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Abstract

The invention relates to a cerebral apoplexy treating effervescence tablet and its preparation method, wherein the formula of the preparation comprises dried cerebral thrombus-treating concrete powder, cross bonding polyvinylpyrrolidone, mannitol, waterless lemon acid, sodium hydrogen carbonate, crystalline cellulose, miropowdered silica gel, magnesium stearate, talcum powder and Aspartame. The preparation employs a direct tabletting method, the bioavailability of the medicament can be improved, and the invention also has the advantages of convenient administration, reduced irritation to esophagus and gastrointestinal tract.

Description

field of invention [0001] The invention relates to a traditional Chinese medicine preparation for treating cerebral apoplexy, in particular to a cerebral thrombus effervescent tablet which uses cerebral thrombus dry extract as a raw material and a preparation method thereof. Background technique [0002] Stroke mainly occurs in middle-aged and elderly people. 90% of strokes occur in patients over 40 years old. China is one of the countries with the highest incidence of stroke in the world, with more than 20 million stroke patients. Acute cerebrovascular disease has leapt to the top cause of death in urban population, and 1.5 million new patients are added every year. With the arrival of my country's aging population and the earlier age of stroke onset, the incidence of stroke will become higher and higher. It has the characteristics of refractory, high recurrence rate, life-long medication, many complications, and high fatality rate, and has always been the enemy of human ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K35/64
Inventor 杨义芳金隽迪
Owner ZHEJIANG HISUN PHARMA CO LTD
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