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Synthesis method of 2-[4-(hydroxyphenoxy)] propionic acid

The technology of a hydroxyphenoxy group and a synthesis method is applied in the synthesis field of the compound 2-[4-]propionic acid, can solve the problems of unsuitability for industrial production, high production cost, harsh reaction conditions, etc., and achieves good industrial application prospects, The effect of low production cost and simple post-processing

Inactive Publication Date: 2011-04-20
NORTHWEST NORMAL UNIVERSITY
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Problems solved by technology

Some of these methods generate a large number of by-products in the reaction process, which are difficult to remove, seriously affecting the purification and yield of the target product; some methods have a long reaction time and low overall yield; High production cost, not suitable for industrial production

Method used

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  • Synthesis method of 2-[4-(hydroxyphenoxy)] propionic acid

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Embodiment Construction

[0018] The synthetic method of 2-[4-(hydroxyphenoxy group)]propionic acid of the present invention will be further described below by specific examples.

[0019] (1) Preparation of ethyl 2-bromopropionate

[0020] Under nitrogen environment, take a dry and clean three-neck flask, add ethyl lactate 3.54g (0.03mol) and phosphorus tribromide 3.25g (0.012mol) successively, stir at room temperature for 5h, and track the reaction process by thin layer chromatography. After the reaction, add saturated sodium bicarbonate solution dropwise to the reaction solution until no gas is generated, then add ethyl acetate with a volume about twice that of the added saturated sodium bicarbonate solution and extract three times to obtain an extract. The extract is dried over magnesium sulfate, and the filtrate is obtained after filtration. Concentrate the filtrate with a RE-52AA rotary evaporator produced by Shanghai Yarong Biochemical Co., Ltd. to obtain a concentrated liquid; then add 2 to 3 ti...

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Abstract

The invention provides a synthesis method of pesticide intermediate 2-[4-(hydroxyphenoxy)] propionic acid. Benzenediol and ethyl lactate are used as raw materials, the diether is prevented from generating through monohydroxy protection, and 2-[4-(hydroxyphenoxy)] propionic acid is prepared through hydroxyl deprotection and hydrolysis. The synthesis method has the advantages of mild condition, short reaction time, simple post treatment, high yield and low production cost and has better industrial application prospects.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and relates to a synthesis method of compound 2-[4-(hydroxyphenoxy)]propionic acid. Synthesis of pesticide intermediates. Background technique [0002] my country is a large agricultural country, and the amount of pesticides is very large. As an important component of the modern agricultural production system, herbicides are the most reliable and economical means of weeding technology in farmland. However, traditional herbicides are gradually being phased out due to their high toxicity, low efficiency, large dosage, and great impact on the environment. Therefore, modern pesticides put forward higher requirements for herbicides: high efficiency and low toxicity. In recent years, a series of herbicides such as diphenyl ethers and phenoxypropionic acids, sulfonylureas and imidazolinones, ureas containing pyridine rings, pyridazines, etc. have been developed successively. Phenoxypropion...

Claims

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Application Information

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IPC IPC(8): C07C59/68C07C27/02
Inventor 杜正银周万伟王芬张雯雯
Owner NORTHWEST NORMAL UNIVERSITY
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