Methods and compositions containing bicifadine are provided for the treatment and prevention of
hyperthermia in mammalian subjects. The methods and compositions may be used to prevent or treat fever, pyresis, menopausal hot flashes; peri menopausal hot flashes, postmenopausal hot flashes, hot flashes caused by anti-
estrogen therapy, hot flashes secondary to
surgical removal of
estrogen producing tissue, hot flashes caused by
radiation therapy, malignant
hyperthermia,
serotonin syndrome, heat
stroke, febrile seizures, and neuroleptic malignant syndrome, among other conditions. Additional compositions and methods are provided employing bicifadine to treat pyresis and simultaneously elicit an
analgesic response in mammalian subjects. Yet additional compositions and methods are provided which employ bicifadine in combination with a second
antipyretic agent, a second
analgesic agent, or a different therapeutic agent to yield more effective
antipyretic treatment tools, and / or dual activity therapeutic methods and formulations useful to prevent or reduce
hyperthermia and one or more additional symptoms (e.g., pain, or depression) in mammalian subjects.