Kaolin reagent quality control product and preparation method and application thereof
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A quality control product, kaolin technology, applied in the preparation of test samples, biological testing, material inspection products, etc., can solve the problems of low stability, accuracy and safety, achieve high accuracy, improve accuracy, good uniformity
Active Publication Date: 2019-03-29
中科精瓒(武汉)医疗技术有限公司
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Problems solved by technology
[0006] Therefore, the technical problem to be solved by the present invention is to overcome the defects of low stability, accuracy and safety of the kaolin reagent used for thromboelastography detection in the prior art, thereby providing a quality control with good accuracy, stability and Kaolin reagent quality control product with high safety
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Embodiment 1
[0063] The present embodiment provides a kind of preparation method of kaolin reagent quality control product, comprises the following steps:
[0064] S1, preparation of platelet-deficient animal plasma
[0065] S11, weigh 3.8g of sodium citrate dihydrate, dissolve it in 80mL of distilled water to prepare a sodium citrate aqueous solution with a concentration of 3.8wt%, and place it in a plastic container cup with a total volume of 1000mL.
[0066] Take 800mL of animal whole blood from at least one of cattle, sheep, pigs, rabbits and horses, and add it to the sodium citrate aqueous solution. When taking blood, gently shake the container cup clockwise or counterclockwise to ensure that the whole blood of the animal is mixed evenly with the sodium citrate aqueous solution. After solidification.
[0067] After blood collection, seal the container cup with plastic wrap, place it in a refrigerator at 2°C for refrigeration, and let it stand for 12 hours until the mixed solution is...
Embodiment 2
[0079] The present embodiment provides a kind of preparation method of kaolin reagent quality control product, comprises the following steps:
[0080] S1, preparation of platelet-deficient animal plasma
[0081] S11, weigh 3.8g of sodium citrate dihydrate, dissolve it in 80mL of distilled water to prepare a sodium citrate aqueous solution with a concentration of 3.8wt%, and place it in a plastic container cup with a total volume of 1000mL.
[0082] Take 800mL of animal whole blood from at least one of cattle, sheep, pigs, rabbits and horses, and add it to the sodium citrate aqueous solution. When taking blood, gently shake the container cup clockwise or counterclockwise to ensure that the whole blood of the animal is mixed evenly with the sodium citrate aqueous solution. After solidification.
[0083] After taking blood, seal the container cup with plastic wrap, place it in a refrigerator at 8°C for refrigeration, and let it stand for 24 hours until the mixed solution is sep...
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Abstract
The invention discloses a kaolin reagent quality control product. The quality control product is lyophilized formulation, and the raw material of the lyophilized formulation includes platelet-deficient animal plasma. The R value of the quality control product is 6-8 min, the K value is 2-5 min, the Angle value is 60 DEG-80 DEG, and the MA value is 23-45 mm. The kaolin reagent quality control product is sensitive to the kaolin reagent reaction, so the accuracy of the quality detection is high, and the quality control requirements for the kaolin preparation in thromboelastography test are met. The quality control product has good reconstitution stability and can be stored for a long time under low temperature. The quality control product uses animal plasma as raw material, thus reducing thecost of the quality control and improving the safety of the quality control operations. The invention also discloses a preparation method of a kaolin reagent quality control product, which can preparethe kaolin reagent quality control product with accurate detection results and high stability. The preparation method is stable and reliable, the preparation process is simple and easy to operate, and the preparation method is suitable for the production and application of kaolin reagent quality control products.
Description
technical field [0001] The invention relates to the field of control standards for blood coagulation detection, in particular to a kaolin reagent quality control product and its preparation method and application. Background technique [0002] Blood coagulation is a very complex physiological and biochemical cascade reaction, and its essence is through a series of enzymatic reactions. The blood coagulation process is gradually participated in by coagulation factors, which can be divided into three stages: the formation of prothrombin activator, the activation of prothrombin and the generation of fibrin. The evaluation test of blood coagulation function is of great significance to the diagnosis, treatment and prognosis of various diseases. It can not only be used for screening and auxiliary diagnosis of bleeding diseases, but also for prediction or risk assessment of thrombotic diseases; Deficiency and von Willebrand's disease can also be used for diagnosis, medication guida...
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