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Thromboelastography TEG quality control and preparation method thereof

A technology of thromboelastography and quality control products, which is applied in the field of blood coagulation detection, can solve the problems of high biological safety risk, unfavorable scale production, and small quantity, and achieve high detection quality and improve the effect of quality detection

Pending Publication Date: 2019-04-09
GUIZHOU JINJIU BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, the output of the existing thrombelastography quality control products is low, and the price is expensive, which cannot meet the market demand for thrombelastography quality control products; on the other hand, the existing thrombelastography quality control products are Human blood is used as the raw material, which is prepared by centrifugation, taking plasma, adding freeze-drying protective agent and preservative, and freeze-drying
[0005] However, human blood mainly comes from hospitals or blood banks, which are expensive, small in quantity, and high in biosafety risks, which are not conducive to large-scale production and are subject to strict supervision.

Method used

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  • Thromboelastography TEG quality control and preparation method thereof
  • Thromboelastography TEG quality control and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation method of the thromboelastography quality control product provided by the present embodiment comprises the following steps:

[0036] Preparation steps of anticoagulant:

[0037] According to the ratio of parts by mass, 3 parts of sodium citrate, 7 parts of sucrose, 3 parts of sodium chloride, 0.01 part of mercury sulfide and 0.5 part of sodium azide were mixed.

[0038] Mixing steps:

[0039] The sodium citrate anticoagulant was mixed with the collected animal blood in a volume ratio of 1:9. Wherein, the animal plasma is porcine plasma.

[0040] Standing steps:

[0041] The mixed animal plasma was allowed to stand at room temperature until the layers were separated, the standing time was 10 h, and the room temperature was 15°C.

[0042] Compared with centrifuged plasma, the use of natural sedimentation can protect coagulation components such as coagulation factors, coagulation factors, fibrinogen, and platelets from being lost or activated.

[0043]...

Embodiment 2

[0050] The preparation method of the thromboelastography quality control product provided in this example is roughly the same as the preparation method provided in Example 1, the difference lies in the different parameters, and the difference is as follows:

[0051] Preparation steps of anticoagulant:

[0052] According to the ratio of parts by mass, 4 parts of sodium citrate, 8 parts of sucrose, 3 parts of sodium chloride, 0.01 part of mercury sulfide and 0.5 part of sodium azide were mixed.

[0053] Mixing steps:

[0054] The sodium citrate anticoagulant was mixed with the collected animal blood in a volume ratio of 1:9. Wherein, the animal plasma is porcine plasma.

[0055] Standing steps:

[0056] The mixed animal plasma was allowed to stand at room temperature until layers were separated, the standing time was 12 hours, and the room temperature was 15°C.

[0057] Extraction steps:

[0058] Extract the platelet-rich animal plasma (supernatant plasma) after standing an...

Embodiment 3

[0064] The preparation method of the thromboelastography quality control product provided in this example is roughly the same as the preparation method provided in Examples 1 and 2, the difference lies in the parameters, which are as follows:

[0065] Preparation steps of anticoagulant:

[0066] According to the ratio of parts by mass, 5 parts of sodium citrate, 10 parts of sucrose, 3 parts of sodium chloride, 0.01 part of mercury sulfide and 0.5 part of sodium azide were mixed.

[0067] Mixing steps:

[0068] The sodium citrate anticoagulant was mixed with the collected animal blood in a volume ratio of 1:9. Wherein, the animal plasma is porcine plasma.

[0069] Standing steps:

[0070] The mixed animal plasma was allowed to stand at room temperature until layers were separated, the standing time was 11 h, and the room temperature was 20°C.

[0071] Extraction steps:

[0072] Extract the platelet-rich animal plasma (supernatant plasma) after standing and stratifying, and d...

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Abstract

The invention discloses a thromboelastography TEG quality control and a preparation method thereof. The preparation method comprises the following steps: taking animal whole blood as a raw material, and protecting blood coagulation factor, fibrinogen, blood platelet and like blood coagulation components by adopting a natural settling process, thereby preventing the components from being lost or activated, and improving the quality of the thromboelastography TEG.

Description

technical field [0001] The invention relates to the technical field of coagulation detection, in particular to a quality control product for a thromboelastography instrument and a preparation method thereof. Background technique [0002] Thromboelastography (TEG) is an analyzer that monitors the coagulation process from the entire dynamic process of platelet aggregation, coagulation, and fibrinolysis, and is used to monitor and analyze the coagulation state of blood samples. Invented by the German Harter in 1948. [0003] The principle is based on the fact that the final result of the blood coagulation process is the formation of a blood clot, and the physical characteristics of the blood clot (clot strength and stability) determine whether it has normal blood coagulation function. [0004] Thromboelastography instrument quality control product, used for the quality inspection of thromboelastography instrument and supporting reagents. On the one hand, the output of the exi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/96
CPCG01N33/96
Inventor 吴卫勇黄蓓张亚林王华亮戎剑陈善钰张自彬陶光铖
Owner GUIZHOU JINJIU BIOTECH
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