3results about How to "Small batch" patented technology

The present application provides a kind of micro tablet, it includes the compound shown in formula I, filler and optionally pharmaceutically acceptable adjuvant, wherein, the diameter of the micro tablet is 1 ~ 3mm, the ratio of diameter and thickness is 0.6 ~ 1.2, the tablet weight is 2.5 ~ 10mg, and includes 1 ~ 5mg compound shown in formula I.The present application also provides the preparation method and pharmaceutical use of the micro tablet.The micro tablet of the present application can realize small dose direct precision dosing, easy to use;It is easy to swallow, can effectively improve the problem of poor palatability of cholic acid drugs, improve medication compliance;It can realize the effect of consistent dissolution characteristics of different doses, ensure the stability of treatment effect under different doses;It can reduce the use of adjuvant, avoid the safety problem of children medication;High stability, conducive to storage and transportation, improve the safety of use;High bioavailability, can more effectively realize in vivo absorption and utilization;Effectively solve the content uniformity problem, reduce the difficulty of process, more suitable for industrial production.

The application discloses a precise and simple FCM ship body forming die. The die is made of a plurality of station plates, positioning clamping plates and face plates which are connected to form a reduced-size frame with ship body lines inside. The face plates in the frame are attached with forming surfaces which are composed of a glass fiber strength layer, a polyester putty layer and a surface gel coat layer. The frame is connected and fixed with a base and a supporting rod made of rectangular tubes to form a stable ship body die. On the face plates in the frame, reference points calibrated by a laser range finder are arranged at the intersection of each station and different waterlines, and the connecting lines of the reference points form a point net which is the same as the ship body lines, so as to mark the size of the forming surface, thereby ensuring the size accuracy, smooth lines and smooth surface of the die. The die is made of light materials, has the advantages of light weight, stable structure, precise lines, simple process, short production cycle and low manufacturing cost, and is suitable for the production of FCM ship bodies with high production technical requirements and small production batches.

The invention relates to the technical field, in particular to a new crystal form of acetyl tetrapeptide-5 and a preparation method and application thereof, an X-ray powder diffraction pattern of the new crystal form of acetyl tetrapeptide-5 has diffraction peaks at the position of 2 theta + / -0.2 degrees, and 2 theta comprises 8.292 degrees, 16.541 degrees, 18.522 degrees, 21.825 degrees and 24.701 degrees. The problems that existing acetyl tetrapeptide-5 freeze-dried powder easily absorbs moisture and is poor in thermal stability are solved, the moisture absorption resistance and temperature stability of the prepared crystal are obviously superior to those of commercially available freeze-dried powder, and the crystal has wide application prospects. Besides, the invention further develops a crystallization process of the stable crystal form of acetyl tetrapeptide-5, the process can complete solid-liquid separation and drying processes in a conventional enamel reaction kettle and a vacuum dryer, a freeze dryer with small batch and high energy consumption is not needed, and the process is more suitable for industrial production.