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Quality detection method of cold stopping capsule

A quality inspection method and capsule technology, which are applied in measurement devices, resistance to vector-borne diseases, material excitation analysis, etc., can solve the problems of large interference, high experimental conditions, and many impurities in ephedrine hydrochloride, so as to improve the detection accuracy. , The effect of reducing detection interference and less water-soluble impurities

Active Publication Date: 2022-07-08
XIANGNAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The current quality standard of Shangfengting Capsules is the thirteenth volume of "Ministry of Health Drug Standards for Traditional Chinese Medicine Prescriptions" and Pharmacopoeia Pages (2002) No. 004. This standard only contains chemical reactions, ephedrine hydrochloride, and TLC of Angelica dahurica. There are no identification and content determination items for other medicinal materials. It can be seen that the standard is simple and cannot effectively and comprehensively control the quality of the entire drug.
Although existing literature reports ephedrine hydrochloride assay method, existing ephedrine hydrochloride impurity is more, interference is bigger, harsh to method, does not have good universal applicability, and
Moreover, although the TLC identification method of existing ephedrine hydrochloride, the existing ephedrine hydrochloride identification method still has the problems of large toxicity and time-consuming
[0004] In addition, although the existing research on the quality control of Shangfengting Capsules is mainly content determination, the mobile phase in each content determination method mostly uses gradient elution, the determination process takes a long time, and requires high experimental conditions, so the durability and applicability Not strong

Method used

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  • Quality detection method of cold stopping capsule
  • Quality detection method of cold stopping capsule
  • Quality detection method of cold stopping capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] The quality detection method of Shangfengting Capsule disclosed in this embodiment includes identifying Angelica dahurica, identifying ephedrine hydrochloride and identifying glycyrrhizic acid,

[0068] TLC identification method is used to identify Angelica dahurica, which includes: taking 3.5 g of the content of the Shangfengting capsule to be tested, adding 20 mL of petroleum ether at 80°C to obtain a mixed solution, ultrasonicating the obtained mixed solution for 20 min, filtering the mixed solution and collecting the filtrate, waiting for The filtrate was volatilized to 1 mL, and the volatilized filtrate was used as the solution of Angelica to be tested; another 0.1 g of Angelica was taken as the reference medicinal material, and 20 mL of petroleum ether at 60 to 90°C was added to obtain a mixed solution. The obtained mixed solution was ultrasonically treated for 20 min and allowed to stand. , get the supernatant liquid, the supernatant liquid is used as Angelica dah...

Embodiment 2

[0084] The quality detection method of Shangfengting Capsule disclosed in this embodiment includes identifying Angelica dahurica, identifying ephedrine hydrochloride and identifying glycyrrhizic acid,

[0085] TLC identification method is used to identify Angelica dahurica, which includes: taking 4 g of the content of the Shangfengting capsule to be tested, adding 15 mL of petroleum ether at 60°C to obtain a mixed solution, ultrasonically treating the obtained mixed solution for 150 min, filtering the mixed solution and collecting the filtrate, waiting for the filtrate Volatilize to 0.5mL, and use the volatilized filtrate as the solution of Angelica to be tested; take another 0.05g of Angelica as a reference medicinal material, add 15mL of petroleum ether at 60°C to obtain a mixed solution, ultrasonically treat the obtained mixed solution for 15min, let stand, and take the solution. The supernatant liquid, the supernatant liquid is used as the Angelica dahurica reference substa...

Embodiment 3

[0101] The quality detection method of Shangfengting Capsule disclosed in this embodiment includes identifying Angelica dahurica, identifying ephedrine hydrochloride and identifying glycyrrhizic acid,

[0102] TLC identification method is used to identify Angelica dahurica, which includes: taking 5 g of the content of the Shangfengting capsule to be tested, adding 30 mL of petroleum ether at 90° C. to obtain a mixed solution, ultrasonicating the obtained mixed solution for 30 min, filtering the mixed solution and collecting the filtrate, waiting for the filtrate Volatilize to 1.5mL, and use the volatilized filtrate as the solution of Angelica to be tested; take another 0.2g of Angelica as the reference medicinal material, add 30mL of petroleum ether at 90°C to obtain a mixed solution, and ultrasonically treat the obtained mixed solution for 30min. The supernatant liquid, the supernatant liquid is used as the Angelica dahurica reference substance solution; according to the thin ...

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Abstract

The invention relates to the technical field of medicine analysis, in particular to a quality detection method of a cold stopping capsule, the quality detection method of the cold stopping capsule comprises the steps of identifying radix angelicae, identifying ephedrine hydrochloride and identifying glycyrrhizic acid, and the quality detection method can rapidly and accurately detect ephedrine hydrochloride in the cold stopping capsule. The toxicity is low; the quality detection method can identify glycyrrhizic acid in the cold stop capsule, and effectively improves the detection comprehensiveness of the cold stop capsule; the quality detection method has the advantages of being easy to operate and good in repeatability.

Description

technical field [0001] The invention relates to the technical field of drug analysis, in particular to a quality detection method for Shangfengting capsules. Background technique [0002] Shangfengting Capsule is composed of 6 medicinal materials including Ephedra, Nepeta, Angelica, Atractylodes (fried), dried tangerine peel and Licorice. It has the effect of dispersing wind-cold. Equivalent. In the recipe, ephedra disperses wind-cold, relieving cough and relieving asthma is the king medicine; Nepeta relieving exterior and dispelling wind, Angelica japonica dispels exterior, relieves pain, dries dampness, clears nose orifice, and Atractylodes japonica invigorates spleen and dampness. Dispels cold, relieves pain, and clears orifices; tangerine peel dries dampness and resolves phlegm, and relieves cough as an adjuvant; licorice reconciles various medicines, resolves phlegm and relieves cough, and acts as a subordinate medicine; the combination of various medicines plays the r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/94G01N30/02G01N30/06G01N30/14G01N30/74G01N21/64
CPCG01N30/90G01N30/94G01N30/02G01N30/06G01N30/14G01N30/74G01N21/64G01N2030/042G01N2030/062Y02A50/30
Inventor 何艳胡小祥刘冠琼徐杨玉
Owner XIANGNAN UNIV
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