The invention discloses preparation and application of an
ovarian cancer cell membrane bionic nano sound-sensitive agent, and belongs to the field of
pharmacy. The technical problem to be solved by the invention is to provide the preparation method of the
ovarian cancer cell membrane bionic nano sound-sensitive agent. The method is based on the homologous targeting property and
immune escape property of an
ovarian cancer cell membrane to
ovarian tumor cells, the SKOV-3 source ovarian
cancer cell membrane (CCM) is innovatively coated on the surfaces of
mesoporous silica-
titanium nanoparticles (MSTN) encapsulated by
manganese dioxide (BSA-MnO2), and a water-soluble sound-sensitive agent azoic compound 2, 2 ', 2', 2 '-tetramethyldisiloxane is added into the
mesoporous silica-
titanium nanoparticles (MSTN) to prepare the SKOV-3 source ovarian
cancer cell membrane. And encapsulating 2, 2 '-azobis [2-(2-imidazoline-2-yl)
propane] dihydrochloride (AIPH) into mesopores of the MSTN to prepare the ovarian
cancer cell membrane bionic nano sound-sensitive agent. The ovarian
cancer cell membrane bionic nano sound-sensitive agent prepared by the invention is high in
biocompatibility, strong in targeting specificity and good in stability, and can effectively escape from
immune system recognition and
elimination. On the basis, the ovarian
cancer cell membrane bionic nano sound-sensitive agent can effectively realize targeted
ultrasound and magnetic
resonance (MRI) bimodal imaging of the sound-sensitive agent to
ovarian cancer cells, effectively realize fixed-point and quantitative release of drugs, achieve adjustable diagnosis and treatment of ovarian cancer, and is expected to provide a new thought for clinical early diagnosis and precise treatment of ovarian cancer.