The invention relates to an orally taken drug for treatment of postoperative scar pain and a preparation method thereof. The drug comprises the following components by mass: 1-3 parts of rhizome sparganii, 1-3 parts of Curcuma zedoaria, 1-3 parts of clove, 1-3 parts of astragalus, 1-3 parts of Alpinia officinarum Hance, 1-3 parts of Evodia rutaecarpa, 1-3 parts of Amomum villosum, 1-3 parts of Codonopsis pilosula, 1-3 parts of Poria cocos, 1-3 parts of piper longum, 1-3 parts of Citrus medica, 1-3 parts of dried ginger and 1-3 parts of bighead atractylodes rhizome. The preparation method of the drug includes: according to the mass part ratio, selecting and purchasing high quality and clean first grade rhizome sparganii, Curcuma zedoaria, clove, astragalus, Alpinia officinarum Hance, Evodia rutaecarpa, Amomum villosum, Codonopsis pilosula, Poria cocos, piper longum, Citrus medica, dried ginger and bighead atractylodes rhizome, removing impurities and dust from the materials respectively for standby use; soaking the medicinal materials in cooled boiled water for about half an hour to permeate drug tissues, then putting the well soaked medicinal materials and the clarified solution for soaking of the materials into an earthen pot together, injecting cooled boiled water higher than the materials by 35mm and performing first decoction for 40min, taking the medicinal liquid, then injecting slight warm boiled water higher than the materials by 30mm and performing second decoction for35min, and carrying out mixing and concentration into 570ml of 50% Chinese herbal liquid for standby use.