37 results about "Inverse suspension polymerization" patented technology

Provided is a method for the production of vinylcarboxamide-containing polymers in a granular, beaded, powdered, or particulate form and subsequent hydrolysis thereof. The vinylcarboxamide-containing polymers and co-polymers, are precipitated in a granular, beaded, powdered, or particulate form employing an inverse suspension polymerization technique.

The invention relates to embolism microspheres with wrinkled surfaces and a preparation method of the embolism microspheres, and belongs to the technical field of medical instruments. The method comprises the following steps: dissolving a high-molecular polymer in water to prepare a high-molecular polymer solution; mixing and reacting the high-molecular polymer solution and a cross-linking agent to obtain a modified polymer solution; adding a water-soluble monomer and an initiator into the modified polymer solution, and mixing to obtain a water-phase solution; under a stirring state, adding the water phase solution into the oil phase solution containing the dispersing agent to obtain a water-in-oil reversed-phase suspension polymerization system; keeping a stirring state, and carrying out heating polymerization, purification and collection on the water-in-oil reversed-phase suspension polymerization system to obtain wet microspheres; standing the wet microspheres in an organic solvent, and removing the organic solvent to obtain transition microspheres; transferring the transition-state microspheres into a vacuum drying oven for drying to obtain dry-state microspheres; and soaking the dry microspheres in water to obtain the embolism microspheres with wrinkled surfaces. The method can improve the drug loading rate and drug loading capacity of the embolization microspheres.

The invention belongs to the field of binders, and particularly relates to a reversed-phase suspension polymerization aqueous binder for a lithium battery and a preparation method of the reversed-phase suspension polymerization aqueous binder. The reversed-phase suspension polymerization aqueous binder for the lithium battery provided by the invention is prepared from the following raw materials: polysaccharide, an acrylic monomer, a dispersing agent, an initiator, a cross-linking agent, neutralizing alkali, an oil-phase solvent and deionized water, and the product is prepared by adopting reversed-phase suspension polymerization. The reversed-phase suspension polymerization aqueous binder for the lithium battery has excellent binding performance, the 180-degree peel strength is larger than 8 N / m, and compared with the prior art, the reversed-phase suspension polymerization aqueous binder for the lithium battery has remarkable progress.

Provided is a novel method for producing water-absorbent resin particles with which it is possible to obtain water-absorbent resin particles having excellent high absorption performance (in particular, physiological saline water retention, physiological saline water absorption under a load of 4.14 kPa, and 5-minute value characteristics of non-pressurized DW). The method for producing water-absorbent resin particles is a method for producing water-absorbent resin particles by subjecting a water-soluble ethylenically unsaturated monomer to reversed-phase suspension polymerization using radical polymerization initiators, at least one of the radical polymerization initiators being an azo compound, the reversed-phase suspension polymerization comprising two or more polymerization steps, in the first-stage polymerization step, (a) 0.01 mmol or more and 0.11 mmol or less of an internal crosslinking agent is used with respect to 1 mol of a water-soluble ethylenically unsaturated monomer used during the first-stage polymerization; in the second-stage polymerization step, (b) 0-0.042 mmol of the internal crosslinking agent is used per 1 mol of the water-soluble ethylenically unsaturated monomer used during the second-stage polymerization, (c) 0.38 mmol or less of the azo compound is used per 1 mol of the water-soluble ethylenically unsaturated monomer used during the second-stage polymerization, and (c) 0.38 mmol or less of the azo compound is used per 1 mol of the water-soluble ethylenically unsaturated monomer used during the second-stage polymerization. A surface crosslinking step is provided after the polymerization step subsequent to the second step.

Disclosed are a polyvinyl alcohol embolic microsphere with a core-shell structure, a preparation method therefor, and use thereof. According to the preparation method, polyvinyl alcohol is taken as a skeleton material, two modified polyvinyl alcohols with different grafting degrees are obtained by means of reacting N-(2,2-dimethoxy)-2-methylacrylamide with polyvinyl alcohol at different ratios, a water-soluble monomer with ionic functional groups and an initiator are mixed with an aqueous solution of low-grafting-degree polyvinyl alcohol to obtain a first aqueous phase, an initiator is mixed with an aqueous solution of high-grafting-degree polyvinyl alcohol to obtain a second aqueous phase, the two aqueous phases are added to an oil phase containing an oil-soluble dispersing agent to form a water-in-oil reverse-phase suspension polymerization system, and reverse-phase suspension polymerization is performed to obtain the polyvinyl alcohol embolic microsphere with a core-shell structure. The core-shell structure polyvinyl alcohol embolization microsphere exhibits an extremely fast drug loading rate and an extremely high drug loading capacity.

The invention provides spherical lignin-phenolic resin, a preparation method thereof and application of the spherical lignin-phenolic resin in adsorption of N-containing organic dye, and belongs to the technical field of adsorption materials. The lignin-phenolic resin with the regular spherical morphology can be prepared through a one-step condensation polymerization reaction by taking lignin, hydroquinone and trioxymethylene as raw materials under an acidic catalysis condition and adopting a reversed-phase suspension polymerization method, the lignin belongs to a renewable resource and has the characteristics of low cost and environmental friendliness, and the lignin-phenolic resin can be used for preparing the lignin-phenolic resin with the regular spherical morphology. The phenolic resin can replace phenols to become a main phenol source, the substitution rate can reach 75%, and the yield of the synthesized phenolic resin reaches up to 60-80%. Besides, abundant phenolic hydroxyl groups, sulfonic acid groups and other oxygen-containing groups can be introduced into the resin by selecting the types of monomers, the cross-linked structure of the resin is changed by regulating and controlling the proportion of the monomers, the adsorption capacity of N-containing organic dyes is effectively improved, and efficient adsorption of rhodamine B and methylene blue can be achieved.

The invention relates to the technical field of high polymer materials, and particularly discloses a preparation method and application of water-absorbent resin with controllable water retention capacity, the preparation method of the water-absorbent resin combines a reversed-phase suspension polymerization method and a solution polymerization method to obtain particles with small particle size difference, and through specific selection of reaction monomers and introduction of temperature-sensitive monomers, the water-absorbent resin with controllable water retention capacity is prepared. When the self-heating body is heated, the water-absorbent resin tends to interact with water molecules to form hydrogen bonds and show hydrophilicity at a lower temperature, and when the self-heating body is heated, polymer chains of the water-absorbent resin tend to be gathered and curled and show hydrophobicity, namely, an electrolyte solution is released, so that the water-retaining capacity is controllable.

The invention relates to the technical field of inorganic mesoporous materials, in particular to an amplification preparation system of millimeter-scale mesoporous carbon spheres. The preparation method comprises the following steps: mixing a phenolic precursor aqueous solution, an aldehyde precursor aqueous solution and a silicon dioxide aqueous solution, and performing prepolymerization to obtain a prepolymer solution; dropwise adding the prepolymer solution into liquid paraffin oil, carrying out reversed-phase suspension polymerization reaction, and then carrying out aging treatment to obtain phenolic resin spheres; calcining the phenolic resin spheres in an inert atmosphere to obtain millimeter-scale carbon spheres; and carrying out etching treatment on the millimeter-level carbon spheres to obtain the millimeter-level mesoporous carbon spheres. The invention creatively provides a pre-polymerization-molding-aging combined system in the engineering mass production of the millimeter-scale mesoporous carbon spheres, determines an amplified preparation process, and defines the influence of process parameters on the product quality; the engineering synthesis steps of the millimeter-scale mesoporous carbon spheres are optimized, the synthesis uncertainty is reduced, the cost of raw materials is reduced, and the large-scale production is facilitated.

Disclosed is a method for producing water-absorbent resin particles, which comprises: a step for preparing an aqueous liquid that contains a monomer of a (meth) acrylic acid compound containing at least one of (meth) acrylic acid or a salt thereof, protoanemonin, and water; a step for forming a particulate water-containing gel polymer containing a polymer of a monomer and water by reversed-phase suspension polymerization in a reaction liquid containing an aqueous liquid and a dispersion medium; and a step for extracting the water-absorbent resin particles containing the polymer from the reaction solution. The aqueous liquid containing protoanemonin in an amount of 6.0 ppm by mass or less relative to the amount of the (meth) acrylic acid compound is prepared.

The application provides a spherical lignin-phenolic resin and a preparation method and application thereof in adsorbing N-containing organic dyes, and belongs to the technical field of adsorbing materials. The lignin-phenolic resin with regular spherical morphology is prepared by one-step condensation polymerization reaction through the reverse suspension polymerization method under acid catalysis, wherein lignin, hydroquinone and trioxane are used as raw materials. The lignin belongs to renewable resources, has the characteristics of low cost and environmental friendliness, can replace phenol as the main phenol source, and the replacement rate can reach 75%. The yield of the synthesized phenolic resin is as high as 60-80%. In addition, the monomer type can be selected to introduce rich phenolic hydroxyl groups, sulfonic acid groups and other oxygen-containing groups in the resin, the monomer ratio is controlled to change the crosslinking structure of the resin, the adsorption capacity of the resin for N-containing organic dyes is effectively improved, and efficient adsorption of rhodamine B and methylene blue can be realized.

The embodiment of the invention provides a supramolecular composite microsphere as well as a preparation method and application thereof, and relates to the technical field of embolism microspheres. The preparation method of the supramolecular composite microspheres comprises the following steps that a water-phase solution and an oil-phase solution are mixed to form a water-in-oil reversed-phase suspension polymerization system, the water-phase solution comprises a water-soluble anionic monomer, a cross-linking agent, a water-soluble pore-forming agent, an initiator and water, and anionic hydrogel microspheres with pore channels are obtained through reaction; and mixing the cationic supramolecular compound with the anionic hydrogel microspheres, so that the cationic supramolecular compound is loaded on the pore channels and the surfaces of the anionic hydrogel microspheres under the action of charges to obtain the supramolecular composite microspheres. According to the preparation method of the supramolecular composite microsphere, the microsphere preparation process has controllability and convenience, and the prepared composite microsphere has excellent broad-spectrum drug loading capacity, has excellent hydrophilicity and mechanical properties, and is suitable for various application scenes such as TACE treatment and the like.

The embodiment of the present application provides a preparation method of secondary cross-linked embolization microspheres and the embolization microspheres, relating to the field of medical interventional therapy materials. The preparation method of the secondary cross-linked embolization microspheres mainly involves formulating an aqueous phase with a modified water-soluble polymer, a water-soluble monomer with ionic functional groups and polymerizable double bonds, and an initiator. The modified water-soluble polymer is obtained by grafting a water-soluble cross-linking agent with double bonds onto the water-soluble polymer. The aqueous phase is dropped into the oil phase to form an inverse suspension polymerization system, and then a first cross-linking reaction is carried out to obtain preliminarily cross-linked embolization microspheres. The preliminarily cross-linked embolization microspheres are subjected to a second cross-linking reaction with a metal ion inorganic salt to obtain secondary cross-linked embolization microspheres. The embolization microspheres of the embodiment of the present application have relatively high compression elasticity, a large drug loading capacity, and a fast drug loading speed.

Provided is a production method by which the amount of a heating medium to be used in a process for producing water-absorbing resin particles can be reduced and the water-absorbing resin particles can be efficiently produced.　This method for producing water-absorbing resin particles comprises a polymerization step, a concentration step, and a drying step in this order. In the polymerization step, a reaction liquid comprising a polymer of a water-soluble, ethylenically unsaturated monomer, water, and a dispersion medium is produced by reversed-phase suspension polymerization. In the concentration step, water is removed by azeotropic distillation while the dispersion medium of the reaction liquid is being refluxed to the reaction liquid, thereby reducing the water content of the reaction liquid to produce a concentrate. In the drying step, the concentrate is dried while being exposed to air, thereby producing a dried object. The content of residual water in the concentrate to be dried in the drying step is 72 mass% or greater with respect to the total mass of the polymer contained in the concentrate.

The invention discloses a polymer surfactant for oil displacement, and relates to the field of tertiary oil recovery. The problem that the oil displacement efficiency and the swept volume of an existing common polymer in a class III oil layer are not obviously improved in the oil layer is mainly solved. The molecular structural formula is as shown in formula (1), wherein R is H or CH3; r1 = H, CH3 or (CH2CH2O) yCH3, and y is in the range of 1 to 20; r2 = CXaCX3, X is halogen, a is 0-2, n, m and p are polymerization degrees, and the numerical ranges of n, m and p are as follows: n is 1-100000, m is 1-20000 and p is 1-30000; the synthesis method comprises the following step: synthesizing the surfactant for oil displacement from a raw material comprising a polymerizable surface active monomer by adopting a photo-initiation solution polymerization method or a reversed-phase suspension polymerization method. The polymer surfactant can be used as a tertiary oil recovery oil-displacing agent, has high viscosity in sewage, has certain surface activity, and can be used for further improving the recovery efficiency after tertiary oil recovery and polymer flooding of medium and low permeability oil layers.

The present application belongs to the field of biomedical materials, discloses a kind of color embolization microspheres and its preparation method and application, color embolization microspheres are synthesized by dispersed phase and continuous phase for inverse suspension polymerization one-step method, dispersed phase is prepared by iodine alkenyl reactive dye, polyvinyl alcohol modified macromolecule solution, initiator and water for injection as main raw material, continuous phase is prepared by oil phase, dispersing agent and catalyst as main raw material;Iodine alkenyl reactive dye in dispersed phase is first obtained by substitution reaction of reactive dye and iodine element, periodic acid in reaction medium, iodine active dye, iodine active dye is then obtained by ring-opening addition under the catalysis of alkaline solution with epoxy butene;The color embolization microspheres synthesized by inverse suspension polymerization one-step method of the present application have the function of developing under X-ray, have drug loading function, dyeing is firm and not easy to decolor, and dyeing process is simple.

The invention provides a CaCO3 / polymer-based plugging agent, a preparation method thereof and a water-based drilling fluid, the preparation method of the CaCO3 / polymer-based plugging agent comprises the following steps: S1, synthesizing CaCO3 in the presence of a modifier to obtain modified CaCO3; s2, taking the modified CaCO3 and a functional monomer as raw materials, adding a cross-linking agent, an initiator and a dispersing agent, and synthesizing a CaCO3 / polymer-based plugging agent by adopting a reversed-phase suspension polymerization method; wherein the functional monomers are styrene, acrylamide and N-vinyl pyrrolidone. The water-based drilling fluid based on the CaCO3 / polymer-based plugging agent is low in cost, has a good plugging effect, has temperature resistance and pressure bearing performance, and can solve the problem of well wall instability of a high-temperature well section.

The invention relates to an embolism microsphere with a photothermal effect and a preparation method and application thereof, and belongs to the technical field of embolism microspheres. The preparation method comprises the following steps: mixing starch and a cross-linking agent in water to obtain an aqueous phase solution; adding the water-phase solution into the oil-phase solution, and carrying out reversed-phase suspension polymerization reaction to obtain starch hydrogel microspheres; wherein the cross-linking agent comprises at least one of sodium trimetaphosphate or sodium tripolyphosphate; oxidizing the starch hydrogel microspheres with sodium periodate to obtain oxidized starch microspheres; the oxidized starch microspheres are subjected to surface modification by adopting dopamine, a polydopamine coating layer is formed on the surfaces of the oxidized starch microspheres, and the embolism microspheres with the photothermal effect are obtained. The embolism microspheres have degradability and drug loading performance at the same time, embolism-chemotherapy-photothermal triple therapy is cooperated, drug release can be controlled through the photothermal effect, and therefore the embolism microspheres can be effectively used for TAE or TACE treatment.

The application provides a preparation method and application of a powder battery binder. The preparation of the powder battery binder comprises the following steps: S1: mixing an aqueous phase mixed solution and an oil phase solution, and then performing inverse suspension polymerization to obtain a suspension; S2: performing post-crosslinking treatment on the suspension to obtain a modified suspension; and S3: removing residual oil phase and water from the modified suspension, and then drying to obtain the powder battery binder. The powder battery binder can avoid the introduction of moisture into positive and negative active materials of a battery, so that the safety performance of the battery is improved, can be used as a binder for the positive and negative active materials, and can reduce the transportation cost of the binder.

Disclosed is a method for producing water-absorbent resin particles, which comprises the steps of: polymerizing a water-soluble ethylenically unsaturated monomer by reversed-phase suspension polymerization in a reaction solution containing a surfactant having an HLB of 7-16 (inclusive), thereby forming a water-containing gel-like polymer; forming agglomerated particles; forming a concentrate by extracting a portion of the water; and surface-crosslinking the agglomerated particles in a mixture containing the concentrate and a surface-crosslinking agent. The amount of the internal crosslinking agent is 0.093 mmol or less per 1 mol of the water-soluble ethylenically unsaturated monomer. The amount of the surfactant is 1.15 mass% or less based on the water-soluble ethylenically unsaturated monomer.

The invention relates to a cyclodextrin hyperbranched microsphere and a preparation method thereof, and belongs to the technical field of embolism microspheres. The preparation method of the cyclodextrin hyperbranched microspheres comprises the following steps: grafting glycidol on cyclodextrin in a hyperbranched manner to obtain a hyperbranched polymer; dissolving a hyperbranched polymer and a cross-linking agent in an alkaline solution to obtain a water phase solution; and adding the water-phase solution into the oil-phase solution to obtain a water-in-oil reversed-phase suspension polymerization system, and reacting to obtain the cyclodextrin hyperbranched microspheres. Cyclodextrin is grafted with glycidol to modify hydrophilic hydroxyl, and hydrophobic drug molecules are captured in combination with hydrophobic cavities of cyclodextrin molecules, so that the microspheres can effectively load drugs; moreover, the dense pore structure of the hyperbranched microsphere is combined with the embedding effect of the hydrophobic cavity, so that the microsphere has a good drug sustained-release effect.

The invention discloses reverse-phase suspension method acrylic acid grafted starch as well as a preparation method and application thereof, and belongs to the technical field of high polymer materials. The preparation method specifically comprises the following steps: (1) adding starch into water, stirring and gelatinizing to obtain gelatinized starch for later use; (2) adding sodium hydroxide into water to obtain a sodium hydroxide solution; (3) firstly adding acrylic acid into a sodium hydroxide solution for neutralization reaction, then adding an initiator and a cross-linking agent, and uniformly stirring to obtain a mixture A; (4) adding the mixture A into gelatinized starch, and uniformly stirring to obtain a mixture B; and (5) adding an organic solvent and a dispersing agent into the reaction flask, uniformly stirring, adding the mixture B, carrying out heating reaction, filtering, washing, dehydrating and drying, thereby obtaining the product. The acrylic acid grafted starch is synthesized by adopting a reversed-phase suspension polymerization method, and the method has the characteristics of uniform product particle size distribution, high water and salt absorption rate, easiness in reaction control and the like.

A method for producing absorbent resin particles is disclosed, comprising preparing an aqueous solution comprising a water-soluble ethylenically unsaturated monomer, water, and a radical polymerization initiator; forming a reaction solution comprising the aqueous solution, a dispersion medium, and a dispersion stabilizer in a polymerization vessel; introducing an inert gas into the polymerization vessel; forming a polymer of the water-soluble ethylenically unsaturated monomer by reverse-phase suspension polymerization in the reaction solution; and obtaining polymer particles containing the polymer from the reaction solution. The temperature of the reaction solution at the time when the introduction of the inert gas into the polymerization vessel begins is 47°C or higher and 70°C or lower.

The invention discloses a phase change material for an ice bag and a preparation method of the phase change material. The phase change material for the ice bag is prepared from ammonium chloride, super absorbent resin, nano silicon dioxide, sodium carboxymethyl cellulose and water. The super absorbent resin is prepared by taking chemically modified chitosan as a macromolecular cross-linking agent, sodium persulfate as an initiator and acrylic acid, 1-vinyl-2-pyrrolidone and 2-acrylamido-2-methylpropanesulfonic acid as monomers through reversed-phase suspension polymerization. Chitosan molecules are subjected to quaternization treatment and grafted with a polyethylene glycol chain segment, and then the chitosan molecules serve as a macromolecular cross-linking agent to participate in polymerization, so that a more stable and tough gel network structure can be formed, and invasion and migration of bacteria are hindered. Sulfonate ions with negative charges can form a firm hydration layer with water molecules, the swelling state of the gel in a salt solution is maintained, and nonionic hydrophilic groups on a polyethylene glycol chain segment and a pyrrolidone functional group can effectively improve the water absorption capacity of the material in the salt solution.

The invention discloses a preparation method of powdery polyacrylic acid thickener microspheres, and belongs to the technical field of high polymer material synthesis. The preparation method comprises the following steps: taking an unsaturated acidic monomer as a main monomer, taking a water-soluble bifunctional monomer as a crosslinking monomer, taking acrylamide and hydrophobic acrylic acid long-chain alkane ester as salt-tolerant functional monomers, taking a redox system as an initiation system, and taking a compound of Span-80 and LAE-6 as a surfactant; and carrying out polymerization reaction by adopting a reversed-phase suspension polymerization method, and carrying out water separation, cooling, filtering and drying after the reaction to obtain the powdery polyacrylic acid thickener microspheres. By introducing the hydrophobic long-chain monomer and optimizing the ratio of the emulsifier, the viscosity retention rate of the product in a high electrolyte environment is remarkably improved, and meanwhile, the product exists in a powder form, is convenient to store and transport, and is suitable for thickening application in the fields of oil exploitation, personal care products, printing and dyeing, food and the like.

Disclosed is a method for producing water-absorbent resin particles, which comprises the steps of: polymerizing a water-soluble ethylenically unsaturated monomer by reversed-phase suspension polymerization in a reaction solution containing a surfactant having an HLB of 7-16 (inclusive), thereby forming a water-containing gel-like polymer; forming agglomerated particles; extracting a portion of the water to form a concentrate; and surface-crosslinking the agglomerated particles in a mixture containing the concentrate and a surface-crosslinking agent. The amount of the internal crosslinking agent is 0.093 mmol or less per 1 mol of the water-soluble ethylenically unsaturated monomer. Polymer particles formed from the water-containing gel-like polymer before the formation of the agglomerated particles have a median diameter of 150 [mu] m or more. The mixture is formed by mixing a surface cross-linking agent and a concentrate containing water at a moisture content of 15-50% by mass (inclusive) based on the mass of the polymer.

The invention relates to lignin developing microspheres as well as a preparation method and application thereof, and belongs to the technical field of embolism agents. The preparation method comprises the following steps: grafting N-hydroxyalkyl acrylamide on lignin to obtain modified lignin; mixing the modified lignin solution, an ionic monomer and an initiator in an aqueous solution to obtain an aqueous phase solution; adding the water-phase solution into the oil-phase solution to form a water-in-oil reversed-phase suspension polymerization system, and reacting to obtain lignin hydrogel microspheres; performing iodination reaction on the lignin hydrogel microspheres and iodine simple substances and / or iodine-containing compounds to obtain the lignin developing microspheres. The lignin developing microsphere has good X-ray developing performance, high strength and elasticity and good catheter passing ability, and the clinical application range of the developing embolism microsphere is widened.

Provided is a method for the production of vinylcarboxamide-containing polymers in a granular, beaded, powdered, or particulate form and subsequent hydrolysis thereof. The vinylcarboxamide-containing polymers and co-polymers, are precipitated in a granular, beaded, powdered, or particulate form employing an inverse suspension polymerization technique.

The invention relates to degradable developing embolism microspheres as well as a preparation method and application thereof, and belongs to the technical field of embolism microspheres. The preparation method of the degradable developing embolism microspheres comprises the following steps: mixing a nonionic iodine contrast agent with a plurality of hydroxyl groups and a cross-linking agent with at least two phosphate groups in an alkaline aqueous solution to obtain an aqueous phase solution; and mixing the water phase solution and the oil phase solution to form a water-in-oil reversed-phase suspension polymerization system, and reacting to obtain the degradable developing embolism microspheres. A nonionic iodine contrast agent and a cross-linking agent with at least two phosphate groups are adopted for cross-linking polymerization, and under the alkaline condition, hydroxyl and the phosphate groups are subjected to a phosphate esterification reaction to form a three-dimensional cross-linked network; the iodine element introduced by the nonionic iodine contrast agent, the phosphate bond generated by the phosphate esterification reaction and the phosphate anions introduced by the cross-linking agent endow the microsphere with developing, drug-loading and degradable properties at the same time, and can be efficiently used for TACE treatment.

The invention relates to the technical field of chromatography medium preparation, in particular to glucan microspheres and a preparation method and application thereof. The preparation method comprises the following steps that S1, glucan, water, an inorganic pore-foaming agent, an organic pore-foaming agent, a hydrophilic surfactant and an activating agent are mixed to prepare a water phase, and the mass ratio of the inorganic pore-foaming agent to the organic pore-foaming agent is (1-10): (1-10); s2, mixing an organic solvent, an oleophylic surfactant and a cross-linking agent to obtain an oil phase; s3, mixing and stirring the oil phase and the water phase, and performing reversed-phase suspension polymerization to obtain glucan microspheres; the rotating speed of stirring is 200 to 700 rpm (revolutions per minute). The inorganic pore-foaming agent and the organic pore-foaming agent in specific dosage are compounded for use, the hydrophilic surfactant and the oleophylic surfactant have a synergistic effect, and the glucan microspheres prepared at a specific stirring speed can give consideration to both excellent resolution and pressure resistance, and can be used as a separation medium.

Disclosed is a method for producing water-absorbent resin particles, which comprises: a step for preparing an aqueous liquid that contains a monomer of a (meth) acrylic acid compound that contains (meth) acrylic acid or / and a salt thereof, an alcohol compound having 1-10 carbon atoms, and water; a step for forming a particulate water-containing gel polymer containing a polymer of a monomer and water by reversed-phase suspension polymerization in a reaction liquid containing an aqueous liquid and a dispersion medium; and a step for extracting the water-absorbent resin particles containing the polymer from the reaction solution. The aqueous liquid containing an alcohol compound in an amount of 800 ppm by mass or less relative to the amount of the (meth) acrylic acid compound is prepared.