Gradient cross-linked high-elasticity embolization microsphere and preparation process thereof

Abstract

The invention discloses a gradient cross-linked high-elasticity embolization microsphere and a preparation process thereof, which belong to the field of medical instruments. According to the method for preparing the gradient cross-linked high-elasticity embolization microsphere, wherein the embolization microsphere is prepared by an aqueous phase and an oil phase, wherein the volume ratio of the aqueous phase to the oil phase is 1% to 30%, The preparation method comprises the following steps: step 1. preparing a reverse suspension polymerization oil phase; step 2. preparing the aqueous phase of the reverse phase suspension polymerization system; and step 3. performing reverse suspension polymerization. The embolization microsphere has the advantages that the embolization microsphere has excellent compressibility and elasticity, can smoothly pass through the microcavity with an inner diameter being smaller than the size of the microsphere itself, the compressibility is greater than 60%of the diameter of the microsphere, and the microsphere rebounds rapidly to a spherical shape after compression; and the microsphere has strong hydrophilic properties, good expansion capacity, fast adsorption capacity, and high drug loading capacity. The preparation process is simple, and can be completed by one polymerization reaction, and first graft modification and then polymerization cannot be required.

Description

technical field [0001] The invention relates to a gradient cross-linked highly elastic embolic microsphere and a preparation process thereof, belonging to the field of medical devices. Background technique [0002] Transcatheter Arterial Chemoembolization (TACE for short) refers to the selective or superselective insertion of a microcatheter into the tumor-supplying target artery through a guide wire, and injects an appropriate amount of embolic material at an appropriate speed to make the target artery Vascular occlusion blocks the blood supply of tumor tissue, leading to tumor ischemia and hypoxia, and achieves the purpose of inhibiting tumor cell growth and promoting tumor cell necrosis and apoptosis. TACE operation mode has received more and more attention and application because of its good clinical effect in the treatment of malignant tumors, uterine fibroids and other diseases. The key to TACE embolization therapy is to select the appropriate embolic material. Since ...

AI Technical Summary

Problems solved by technology

This embolic microsphere has a certain drug-loading capacity and compression elasticity, but because its cross-linking is achieved through the polymerization of polyvinyl alcohol-grafted monomers with ionic functional groups, when there are more polyvinyl alcohol-grafted monomers, the microspheres The more ionic functional groups it contains, the stronger its drug-loading capacity will be, but at the same time, the higher the degree of cross-linking of polyvinyl alcohol microspheres, the worse the compressibility of the microspheres will be, and the expansion performance and drug-loading speed of the microspheres will This mutual restriction limits the optimization of the drug-loading performance and compression elasticity of embolic microspheres. Therefore, in order to achieve embolic materials with more ideal performance, new synthesis methods and microsphere structural characteristics are needed to break through This mutually restrictive pattern

Images