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Polyvinyl alcohol-borax microsphere and preparation method thereof

A technology of polyvinyl alcohol and borax, which is applied in the field of polyvinyl alcohol-borax microspheres and their preparation, can solve problems such as irritation and achieve the effects of good thermal stability, high utilization rate of crosslinking agent and simple reaction conditions

Active Publication Date: 2013-03-13
IMEIK TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Zhao Daqing, Tan Jinquan, etc. have disclosed the use of glutaraldehyde as a cross-linking agent in "Preparation and Research of Polyvinyl Alcohol Microspheres" ("China New Drugs", Volume 14, No. 2, 2005, pages 181-184). agent, using acetal reaction to prepare polyvinyl alcohol microspheres, but glutaraldehyde is a broad-spectrum and high-efficiency fungicide, which has a strong stimulating effect on the human body. Therefore, glutaraldehyde is used as a crosslinking agent. Polyvinyl alcohol microspheres have certain risks when used as soft tissue fillers

Method used

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  • Polyvinyl alcohol-borax microsphere and preparation method thereof
  • Polyvinyl alcohol-borax microsphere and preparation method thereof
  • Polyvinyl alcohol-borax microsphere and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] The reagents used in the present invention are all medical grade or pharmaceutical grade.

[0026] Dissolve 5g of polyvinyl alcohol (PVA) in boiling water to prepare 100ml of PVA aqueous solution with a mass fraction of 5%, adjust the pH value to 1 with 2mol / L hydrochloric acid, and use this solution as the water phase. Dissolve 2g of sorbitan oleate (Span-80) in 200ml of liquid paraffin, and use this solution as the oil phase. Add the above two solutions into a 500ml three-necked bottle, and adjust the rotation speed to 600 rpm to make the water phase liquid beads reach a suitable particle size. Dissolve 1.0 g of sodium tetraborate decahydrate (borax) in 10 ml of hydrochloric acid with a concentration of 1 mol / L and add it dropwise to the reaction system. Raise the temperature to 60°C for 4 hours, observe the particle size of the PVA spherical gel particles in the system at this time with a microscope, then add 10ml of medicinal sodium phosphate solution with a mass f...

Embodiment 2

[0028] Dissolve 10g of polyvinyl alcohol (PVA) in boiling water to obtain 100ml of PVA aqueous solution with a mass fraction of 10%, adjust the pH value to 1 with 2mol / L hydrochloric acid, and use this solution as the water phase. Dissolve 8 g of sorbitan oleate (Span-80) in 200 ml of liquid paraffin, and use this solution as the oil phase. Add the above two solutions into a 500ml three-necked bottle, and adjust the rotation speed to 700 rpm to make the water phase liquid beads reach a suitable particle size. Dissolve 4.0 g of sodium tetraborate decahydrate (borax) in 30 ml of hydrochloric acid with a concentration of 1 mol / L and add it dropwise to the reaction system. Raise the temperature to 60°C for 4 hours, observe the particle size of the PVA spherical gel particles in the system at this time with a microscope, then add 10ml of medicinal sodium phosphate solution with a mass fraction of 20%, and raise the temperature to 90°C to solidify the PVA spherical gel particles. C...

Embodiment 3

[0030] Dissolve 8g of polyvinyl alcohol (PVA) in boiling water to prepare 100ml of PVA aqueous solution with a mass fraction of 8%, adjust the pH value to 1 with 2mol / L hydrochloric acid, and use this solution as the water phase. Dissolve 5 g of sorbitan oleate (Span-80) in 200 ml of liquid paraffin, and use this solution as the oil phase. Add the above two solutions into a 500ml three-necked bottle, and adjust the rotation speed to 650 rpm to make the water phase liquid beads reach a suitable particle size. Dissolve 1.0 g of sodium tetraborate decahydrate (borax) in 10 ml of hydrochloric acid with a concentration of 1 mol / L and add it dropwise to the reaction system. Raise the temperature to 60°C for 4 hours, observe the particle size of the PVA spherical gel particles in the system at this time with a microscope, then add 10ml of medicinal sodium phosphate solution with a mass fraction of 20%, and raise the temperature to 90°C to solidify the PVA spherical gel particles. Cu...

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Abstract

The invention relates to a polyvinyl alcohol-borax microsphere and a preparation method thereof. In particular, the technical method adopts borax as the crosslinking agent to prepare a polyvinyl alcohol microsphere by means of water-in-oil reversed phase suspension polymerization. The method consists of: taking liquid paraffin-sorbitan monooleate system as the dispersion phase, adopting a polyvinyl alcohol water solution as the polymerization phase, and using borax as the crosslinking agent, subjecting them and polyvinyl alcohol to an esterification crosslinking reaction in an acidic condition, employing sodium phosphate as the pH adjusting agent and the curing agent, and leaving a microsphere to cure, thus obtaining the polyvinyl alcohol-borax microsphere. In the invention, borax is adopted as the crosslinking agent, which is non-toxic and non-simulating to human bodies, thus avoiding using dialdehyde, diacyl chloride and other crosslinking agents having toxicity to human bodies and stimulation to the skin, as well as potential safety hazards. The prepared polyvinyl alcohol microsphere has good thermal stability, no bacterium, no toxicity, no pyrogen, and good biocompatibility.

Description

technical field [0001] The invention relates to a polyvinyl alcohol-borax microsphere and a preparation method thereof, specifically a process method for preparing polyvinyl alcohol microspheres by using borax as a crosslinking agent. The esterification and crosslinking of vinyl alcohol makes the polyvinyl alcohol solidify in the water phase to form microspheres. The invention has the advantages of simple reaction conditions, high utilization rate of the crosslinking agent, good thermal stability of microspheres, sterility, non-toxicity, no pyrogen, biocompatibility and the like. Background technique [0002] Polyvinyl alcohol (PVA) is a water-soluble polymer material. Animal experiments have shown that it is completely harmless, non-toxic, non-irritating, and has good biocompatibility. It can be slowly degraded in the body and is widely used in the preparation of Hemostatic fibers and artificial skin can also be used for contraceptive pills, plasma substitutes, eye drops, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08L29/04C08K3/38
Inventor 简军李睿智石毅峰
Owner IMEIK TECH DEV CO LTD
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