22 results about "Sorbitan oleate" patented technology

The invention relates to the field of coal dressing flotation reagents, and discloses a green coal dressing flotation reagent and a preparation method and application thereof. The invention provides a green coal dressing flotation reagent which is composed of 70-80 parts of methyl oleate, 15-30 parts of methyl palmitate and 3-6 parts of an emulsifying agent (sorbitan oleate Span80). The preparation method comprises the following steps: firstly, weighing raw materials, magnetically stirring methyl oleate and methyl palmitate for 30 minutes, then mixing with sorbitan oleate (Span80), and heating and stirring in a water bath at 55 DEG C for 2 hours to obtain the medicament. In the application of coal slime flotation, the reagent solution is added into ore pulp and matched with a foaming agent, and flotation clean coal is formed by utilizing bubbles to carry coal slime particles. A plurality of groups of experiments show that the agent is excellent in performance, the clean coal recovery rate can reach 79.66%, the ash content is as low as 10.91%, the agent dosage is remarkably reduced compared with a traditional collecting agent, meanwhile, raw materials are green and environmentally friendly, the coal dressing industry is effectively promoted to develop towards the efficient and green direction, and the agent has extremely high application value.

The invention relates to the technical field of microcapsules, provides a magnetic microcapsule capable of preventing particle sedimentation, a preparation method of the magnetic microcapsule and a magnetic film, and aims to solve the problems of low writing smoothness and poor trace durability due to particle sedimentation and aggregation in the prior art. The magnetic microcapsule comprises a wall material and a core material, the wall material is a mixture comprising an anionic polymer and a cationic polymer, and the core material is a mixture comprising magnetic particles, non-magnetic particles, an oily solvent and a suspension stabilizer; the suspension stabilizer comprises any one or more of phthalic ester, polyamide wax, polysiloxane, sorbitan oleate, sorbitan monostearate, silicon dioxide, magnesium aluminum silicate and magnesium lithium silicate; according to the invention, magnetic particles and non-magnetic particles can be prevented from settling and gathering, and writing fluency and trace durability are ensured.

The invention discloses external emulsifiable paste for directionally delivering tranexamic acid to an epidermal layer, which is prepared from the following raw materials in percentage by weight: 1-15% of tranexamic acid, 0.5-7% of alpha-arbutin, 0.3-4% of edetate disodium, 1-5% of azone, 1-5% of sodium dodecyl benzene sulfonate and the balance of water. The skin care product is prepared from, by weight, 0.1%-2% of salicylic acid, 1%-10% of glycerin, 2%-15% of propylene glycol, 0.1%-4% of tween-80 or 0.4%-2% of sorbitan oleate, 0.5%-5% of alpha-tocopherol, 0.5%-5% of diisostearyl alcohol malate, 0.5%-6% of soybean phospholipid, 1%-10% of glycerin monostearate, 0.5%-10% of tetradecanol, 0.02%-0.1% of propyl hydroxybenzoate, 1%-10% of stearic acid, 0.5%-6% of stearyl alcohol and the balance water. Meanwhile, the invention also discloses a preparation method, experiments show that the external cream prepared by the invention has strong capacity of delivering tranexamic acid to the epidermal layer and can ensure that the tranexamic acid can be quickly absorbed by cells to take effect, and the defect that tranexamic acid is difficult to pass through skin cuticle obstacles due to strong hydrophilicity is overcome.

The invention relates to adapalene benzoyl peroxide gel. The adapalene benzoyl peroxide gel is prepared from adapalene, benzoyl peroxide, docusate sodium, edetate disodium, glycerol, poloxamer 124, propylene glycol and an acrylamide / acryloyl sodium dimethyl taurate copolymer amp, wherein the acrylamide / acryloyl sodium dimethyl taurate copolymer amp is a mixture of sodium acetate and sodium acetate; isohexadecane amp; isohexadecane amp; 80 amp of polysorbate; adding sorbitan oleate and purified water; the preparation method of the adapalene benzoyl peroxide gel comprises the following steps: S1, preparing a solid dispersion; S2, preparing an active component phase; S3, preparing a water phase; and S4, preparing the gel. The adapalene benzoyl peroxide gel and the preparation method thereof provided by the invention are used for solving the problem of uniformity of two raw material medicines in the adapalene benzoyl peroxide gel, so that the uniformity and the particle size of the two raw material medicines in a container in the gel meet regulations, and the preparation quality and the clinical curative effect are guaranteed. The gel preparation is simple in technological process, easy to operate and suitable for industrial large-scale production.

The invention discloses sorbitan oleate modified castor oil-based waterborne polyurethane and a preparation method, and belongs to the technical field of paints.Castor oil is used as a soft segment, isophorone diisocyanate is used as a hard segment, and the isocyanate index of polyurethane is fixed to be about 1.1; the preparation method comprises the following steps: introducing sorbitan oleate with rigid furan and an aliphatic hydrophobic side chain into a polyurethane molecular network by adopting a prepolymerization method, and preparing a series of sorbitan oleate modified castor oil based cationic waterborne polyurethane emulsions by adopting N-methyldiethanolamine as a cationic hydrophilic chain extender and 1-4 butanediol as a micromolecular chain extender. According to the sorbitan oleate modified castor oil-based waterborne polyurethane and the preparation method, sorbitan oleate is introduced into a polyurethane molecular network, so that the mechanical property of a castor oil-based waterborne polyurethane material is effectively improved, and the water resistance and corrosion resistance of the castor oil-based waterborne polyurethane material are improved.

According to the green and environment-friendly antibacterial polyurethane adhesive and the synthesis method thereof, renewable sorbitan oleate and tannic acid are introduced into a waterborne polyurethane adhesive, so that the environmental protection property of the adhesive is improved, and the water resistance and flowability of the adhesive can be effectively improved; and the adhesive is endowed with antibacterial and mildew-proof properties and higher bonding strength. The sorbitan oleate and the tannic acid are both subjected to chemical reaction with the toluene diisocynate, and polyhydroxy structures of the sorbitan oleate and the tannic acid promote cross-linking among molecules and enhance a molecular network of the adhesive, so that the cementing performance of the adhesive is improved; the hydroxyl position of sorbitan oleate and a long alkane chain also increase the synthesis yield of the adhesive and the toughness and water resistance of the product, tannic acid is used as a cross-linking agent on one hand, and on the other hand, the interaction of a polyphenol structure in tannic acid and an adhesive matrix can inhibit the growth of mould and bacteria on the other hand, so that the antibacterial and mildew-proof properties of the adhesive are also improved, and the service life of the adhesive is prolonged. And the mildew-proof capability is improved by more than 80%.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a pharmaceutical composition containing chlorbuconazole and a preparation method of the pharmaceutical composition. The invention provides a pharmaceutical composition containing chlorbuconazole as well as a preparation method and application of the pharmaceutical composition. Specifically, the invention discloses a pharmaceutical composition, the pharmaceutical composition comprises chlorbuconazole or a pharmaceutically acceptable salt thereof, polyethylene glycol 400, sorbitan oleate and polysorbate 80, the chlorbuconazole or the pharmaceutically acceptable salt thereof accounts for 1-10% of the total weight of the pharmaceutical composition, and the moisture content of the pharmaceutical composition is lower than 10%. The pharmaceutical composition disclosed by the invention has good dissolution rate and relatively high stability.

The present invention relates to an aqueous acrylic dispersion, a preparation method thereof and an application, belonging to the technical field of aqueous coatings. The aqueous acrylic dispersion described in the present invention comprises a first copolymer; the copolymerization monomers of the first copolymer include a first monomer, and the first monomer is sorbitan oleate; the first monomer accounts for 1-20 wt% of the solid content of the aqueous acrylic dispersion; the solid content acid value of the aqueous acrylic dispersion is 15-35 mg KOH / g, and the solid content hydroxyl value is 50-165 mg KOH / g. The aqueous acrylic dispersion has excellent storage stability, and the aqueous coating using the aqueous acrylic dispersion as the main film-forming substance has the advantages of high gloss, long pot life and good water resistance.

The invention provides a ketorolac patch composition, a ketorolac patch as well as a preparation method and application of the ketorolac patch. The ketorolac patch composition comprises an active component, a matrix material and a transdermal enhancer, the transdermal enhancer comprises at least two of lactic acid, oleic acid, phosphoric acid, tartaric acid, citric acid, fumaric acid, malic acid, isopropyl myristate, propylene glycol monolaurate, glyceryl monolinoleate, glyceryl triacetate, diisopropyl adipate, triethyl citrate, polyglycerol oleate and sorbitan oleate (Span 80); preferably, the transdermal enhancer is prepared from at least two of isopropyl myristate, triethyl citrate, polyglycerol oleate, glyceryl triacetate, oleic acid, sorbitan oleate (Span 80), lactic acid and citric acid; the transdermal enhancer provided by the invention comprises the compounding of at least two of the substances, so that the transdermal diffusion performance of the ketorolac patch composition can be greatly improved.

The invention relates to the technical field of oil-based drilling fluid emulsifiers, and discloses an oil-based drilling fluid emulsifier and a preparation method thereof. The invention obtains an oil-based drilling fluid emulsifier by adding a sulfonated amide surfactant, a triazine-modified bisphenol A epoxy resin, lignin, and anhydrous sorbitan oleate into a reactor and stirring. The amide group and the long carbon chain in the sulfonated amide surfactant can be arranged in a directional manner and adsorbed on the oil-water interface to form a high-strength interface film, so that the emulsifier has temperature resistance and emulsification; the sulfonic acid group improves the strength of the emulsifier interface film, thereby enhancing the high temperature resistance and stability of the emulsifier. The epoxy resin helps to form smaller and more stable emulsion droplets, thereby improving the stability of the emulsifier; the chlorine atoms in cyanuric chloride can react with the hydroxyl group and the amine group in the emulsifier molecules to form a stable chemical bond, so that the emulsifier molecules are arranged more closely at the oil-water interface, thereby improving the stability of the emulsifier.

The invention discloses a novel sodium aluminate seed crystal decomposition crystallization auxiliary agent and a preparation method thereof, and the novel sodium aluminate seed crystal decomposition crystallization auxiliary agent comprises the following components by mass: 0.1%-1% of sorbitan oleate sodium sulfonate, 0.1%-1% of secondary alkyl sodium sulfonate, and the balance of distilled water. The preparation method comprises the following specific preparation steps: weighing sorbitan oleate sodium sulfonate and secondary alkyl sodium sulfonate according to a ratio, and putting the weighed materials into a beaker; and adding distilled water into the beaker until the total weight is 100g, stirring for 5-10 minutes, and dissolving into uniform liquid. According to the invention, the independently designed and synthesized sorbitan oleate sodium sulfonate and the anionic surfactant secondary alkyl sodium sulfonate are compounded, and the two components have a synergistic enhancement effect, so that agglomeration among aluminum hydroxide particles is effectively promoted, and the decomposition rate of a sodium aluminate solution is improved. The composition is simple, the preparation technology is simple, industrial production is easy, and the good industrial application prospect is achieved.

The present invention relates to the field of cosmetics technology, specifically to a repairing composition for lowering the freezing point of essential oils and a preparation method thereof. The composition comprises slowly dripping phytosterol / octyldodecanol lauroyl glutamate into jojoba seed oil stirred at 200 rpm. The stirring speed is then reduced, sorbitan oleate is added, and the mixture is stirred until uniform. A ginseng root extract extracted with supercritical CO2 is then added to produce the repairing composition. In the present invention, the phytosterol / octyldodecanol lauroyl glutamate is slowly dripped into the stirred jojoba seed oil to form fine microspheres. The sorbitan oleate's opening-like structure then separates the microspheres, reducing the interaction between them and lowering the freezing point of wax and ester components in the oil. The ginseng root is then extracted with supercritical CO2 to extract more volatile oils and lower the freezing point of the ginseng root extract. The repairing composition not only has a lower freezing point but also simultaneously helps lower the freezing point of the essential oil to which it is added.

The present invention relates to a moisturizing, itching relieving, soothing and repairing cream, the cream comprises sea cucumber peptide, sophocarpidine, inositol, a moisturizing agent, an emulsifier, an antioxidant, a preservative, an emollient, a flavoring agent and a solvent, the moisturizing agent is selected from one or more of glycerol, polydimethylsiloxane, lecithin, ceramide EOP and sodium hyaluronate, and the emulsifier is selected from one or more of glycerol, polydimethylsiloxane, lecithin, ceramide EOP and sodium hyaluronate. The emulsifier is selected from one or more of stearic acid, cetyl alcohol and sorbitan oleate. The cream disclosed by the invention takes the sea cucumber peptide, the sophocarpidine and the inositol as active substances, and synergistically exerts the effects of moisturizing, relieving itching, relieving and repairing. The cream is uniform in cream body color, free of layering, fine and smooth in texture and free of sand grain feeling, and the cream preparation technology is suitable for large-scale industrial production.

The present application belongs to the technical field of external preparations of traditional Chinese medicine, and relates to a cream containing imperatorin and capable of promoting skin wound healing and a preparation method thereof. The cream takes imperatorin and puerarin as core effective components, magnesium lithium silicate and sodium hyaluronate as synergistic repair components, sorbitan oleate and lanolin as emulsifiers, refined sesame oil, squalane and white petrolatum as oil phase matrix, and further includes glycerol, and the rest is deionized water. Animal experiment results show that the cream can promote collagen fiber generation of granulation tissue, promote polarization of repair type macrophages, significantly optimize repair quality and reduce scar formation while improving wound healing rate, and has good safety. The preparation process is stable and controllable, and is suitable for industrial production. The cream can be used for I and II degree mild burn and scald, skin abrasion and other traumatic wounds, and is also suitable for skin problems such as postoperative wound repair of medical beauty and hand and foot chapped skin, has wide clinical application range, and has good application prospect and popularization value.

The invention provides a rhodiola rosea nano-emulsion. The rhodiola rosea nano-emulsion comprises a rhodiola rosea extract, an interfacial agent, a co-interfacial agent and oil. The surfactant comprises diethylene glycol monoethyl ester or polysorbate 80, the co-surfactant comprises polysorbate 80, sorbitan oleate 80, or caprylic / capric polyethylene glycol glyceride, and the oil comprises medium chain triglyceride or soybean oil, and coats the rhodiola rosea extract in an oil-in-water manner. The invention also provides a method for preparing the rhodiola rosea nano-emulsion, so as to provide the rhodiola rosea nano-emulsion suitable for drug delivery.

Provided is a Rhodiola rosea nanoemulsion, comprising Rhodiola rosea extract, surfactant, cosurfactant and oil. The surfactant includes diethylene glycol monoethyl ester or polysorbate 80, the cosurfactant includes polysorbate 80, sorbitan oleate 80, or caprylocaproyl polyoxyl-8 glycerides (Labrasol®), and the oil includes Labrafac™ oil or soybean oil, and Rhodiola rosea extract coated in oil-in-water form. Also provided is a method for preparing the Rhodiola rosea nanoemulsion, so as to provide the Rhodiola rosea nanoemulsion suitable for drug delivery.

The present application provides a ketorolac patch composition, a ketorolac patch and a preparation method and application thereof. The ketorolac patch composition of the present application comprises an active ingredient, a matrix material and a transdermal enhancer, the transdermal enhancer comprises at least two of lactic acid, oleic acid, phosphoric acid, tartaric acid, citric acid, fumaric acid, malic acid, isopropyl myristate, propylene glycol monolaurate, glycerol monooleate, glycerol triacetate, diisopropyl adipate, triethyl citrate, polyglycerol oleate, sorbitan oleate (Span 80); preferably, the transdermal enhancer comprises at least two of isopropyl myristate, triethyl citrate, polyglycerol oleate, glycerol triacetate, oleic acid, sorbitan oleate (Span 80), lactic acid and citric acid; the transdermal enhancer of the present application comprises a complex of at least two of the above-mentioned substances, which can greatly improve the transdermal diffusion performance of the ketorolac patch composition.

This invention belongs to the field of pharmaceutical preparations, and particularly relates to a dimethicone emulsion and its preparation method. The preparation method provided by this invention includes the following steps: a) grinding and mixing dimethicone and silica at 100-140°C to obtain an oil phase mixture; b) mixing sodium saccharin, ethylparaben, and water, and then mixing with sodium carboxymethyl cellulose to obtain an aqueous phase mixture; c) mixing the oil phase mixture, polysorbate 80, and sorbitan oleate, and then mixing with a portion of the aqueous phase mixture, followed by homogenization to obtain a primary emulsion; d) mixing the remaining aqueous phase mixture, an ethanol solution of butylated hydroxytoluene, and a fragrance, and then mixing with the primary emulsion, finally adding water to make up to a fixed volume and mixing to obtain the dimethicone emulsion. The preparation method provided by this invention has a short production cycle and high production efficiency, and the resulting dimethicone emulsion product has excellent defoaming ability and quality stability.

The invention discloses an anti-aging sole material and a preparation method thereof, and belongs to the technical field of high polymer materials. The anti-aging sole material is prepared from the following raw materials in parts by weight: 50 to 60 parts of ethylene propylene diene monomer, 10 to 20 parts of acrylate rubber, 6 to 12 parts of modified rectorite, 1 to 1.5 parts of sorbitan oleate, 1 to 2 parts of vulcanizing agent, 0.5 to 0.8 part of vulcanization accelerator, 1 to 3 parts of lubricant and 0.5 to 0.8 part of cross-linking agent. The modified rectorite has good compatibility with other raw materials in the sole material, and the modified rectorite can be highly dispersed and stably exist in the sole material, so that the rectorite, the hindered phenol structure and the amine anti-aging component in the modified rectorite have a synergistic effect; the materials jointly enable the sole material to have efficient and lasting thermo-oxidative aging resistance and ultraviolet aging resistance, and the service life of the sole material is greatly prolonged.

The application discloses a kind of hydrophobic drag reducer and preparation method thereof, belong to downhole working fluid technical field.Effective component of the raw material of the drag reducer made in the application, by weight fraction, includes: acrylamide 15~20 parts, acrylic acid 10~15 parts, 2-acrylamide-2-methylpropane sulfonic acid 2~3 parts, modified nanosilica 1~2 parts, initiator A 0.1~0.5 parts, chelating agent 0.5~1 parts, white oil 30~40 parts, sorbitan oleate 4~6 parts, polyoxyethylene sorbitol oleic acid ester 1~2 parts and initiator B 1~2 parts.The drag reducer of the application can reverse the wettability of rock surface to hydrophobicity, under the action of capillary force, water is difficult to enter reservoir pore, reduce the degree of shale reservoir hydration expansion, at the same time, increase the flowback rate of fracturing fluid.The application is suitable for drag reducer in shale oil and gas exploration and development.

The invention discloses a fluorescent immunoassay reagent for detecting helicobacter pylori of dogs and cats. The fluorescent immunoassay reagent comprises a kit and application of the kit. The fluorescence immunoassay reagent comprises a sample diluent; the sample diluent is prepared from 0.01 to 0.03 M of Bicine-Tris composite buffer system, 0.2 to 0.8 percent (w / v) of polyvinylpyrrolidone K40, 0.003 to 0.007 M of disodium ethylene diamine tetraacetate, 0.5 to 2 percent (w / v) of KCl, 0.5 to 2 percent (w / v) of Tween 80 and 0.1 to 1 percent (w / v) of sorbitan oleate; the pH (Potential of Hydrogen) is 6.5 to 7.8. When the fluorescent immunoassay reagent is used for detecting the helicobacter pylori of dogs and cats, various sample types can be compatible, and samples are not easy to degrade; the problem of microsphere aggregation is solved, non-specific binding is reduced, and sensitivity is improved.

The invention relates to the technical field of emulsifier synthesis, in particular to a preparation method of sorbitan cashew nut oleate, which comprises the following steps: adding sorbitan, vegetable oleic acid and a catalyst into a reactor, fully mixing, reacting for 2-4 hours at the constant temperature of 120-170 DEG C in a vacuum state, ending the reaction, and naturally cooling to room temperature, thereby obtaining the sorbitan cashew nut oleate. The sorbitan cashew nut oleate is obtained. According to the present invention, the sorbitan oleate is produced by using the biomass-sourced low-cost cashew nut shell oleic acid, such that the problems of high temperature and complex product components in the current sorbitan oleate synthesis process are solved, and the new idea is provided for the sorbitan oleate synthesis process. The preparation method is low in material cost, high in activity, small in energy consumption and relatively single in product component, and the produced sorbitan cashew nut oleate emulsifier is moderate in viscosity, relatively low in acid value and relatively high in hydroxyl value.