6 results about "Sorbitan oleate" patented technology

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a pharmaceutical composition containing chlorbuconazole and a preparation method of the pharmaceutical composition. The invention provides a pharmaceutical composition containing chlorbuconazole as well as a preparation method and application of the pharmaceutical composition. Specifically, the invention discloses a pharmaceutical composition, the pharmaceutical composition comprises chlorbuconazole or a pharmaceutically acceptable salt thereof, polyethylene glycol 400, sorbitan oleate and polysorbate 80, the chlorbuconazole or the pharmaceutically acceptable salt thereof accounts for 1-10% of the total weight of the pharmaceutical composition, and the moisture content of the pharmaceutical composition is lower than 10%. The pharmaceutical composition disclosed by the invention has good dissolution rate and relatively high stability.

The present application belongs to the technical field of external preparations of traditional Chinese medicine, and relates to a cream containing imperatorin and capable of promoting skin wound healing and a preparation method thereof. The cream takes imperatorin and puerarin as core effective components, magnesium lithium silicate and sodium hyaluronate as synergistic repair components, sorbitan oleate and lanolin as emulsifiers, refined sesame oil, squalane and white petrolatum as oil phase matrix, and further includes glycerol, and the rest is deionized water. Animal experiment results show that the cream can promote collagen fiber generation of granulation tissue, promote polarization of repair type macrophages, significantly optimize repair quality and reduce scar formation while improving wound healing rate, and has good safety. The preparation process is stable and controllable, and is suitable for industrial production. The cream can be used for I and II degree mild burn and scald, skin abrasion and other traumatic wounds, and is also suitable for skin problems such as postoperative wound repair of medical beauty and hand and foot chapped skin, has wide clinical application range, and has good application prospect and popularization value.

The present application provides a ketorolac patch composition, a ketorolac patch and a preparation method and application thereof. The ketorolac patch composition of the present application comprises an active ingredient, a matrix material and a transdermal enhancer, the transdermal enhancer comprises at least two of lactic acid, oleic acid, phosphoric acid, tartaric acid, citric acid, fumaric acid, malic acid, isopropyl myristate, propylene glycol monolaurate, glycerol monooleate, glycerol triacetate, diisopropyl adipate, triethyl citrate, polyglycerol oleate, sorbitan oleate (Span 80); preferably, the transdermal enhancer comprises at least two of isopropyl myristate, triethyl citrate, polyglycerol oleate, glycerol triacetate, oleic acid, sorbitan oleate (Span 80), lactic acid and citric acid; the transdermal enhancer of the present application comprises a complex of at least two of the above-mentioned substances, which can greatly improve the transdermal diffusion performance of the ketorolac patch composition.

This invention belongs to the field of pharmaceutical preparations, and particularly relates to a dimethicone emulsion and its preparation method. The preparation method provided by this invention includes the following steps: a) grinding and mixing dimethicone and silica at 100-140°C to obtain an oil phase mixture; b) mixing sodium saccharin, ethylparaben, and water, and then mixing with sodium carboxymethyl cellulose to obtain an aqueous phase mixture; c) mixing the oil phase mixture, polysorbate 80, and sorbitan oleate, and then mixing with a portion of the aqueous phase mixture, followed by homogenization to obtain a primary emulsion; d) mixing the remaining aqueous phase mixture, an ethanol solution of butylated hydroxytoluene, and a fragrance, and then mixing with the primary emulsion, finally adding water to make up to a fixed volume and mixing to obtain the dimethicone emulsion. The preparation method provided by this invention has a short production cycle and high production efficiency, and the resulting dimethicone emulsion product has excellent defoaming ability and quality stability.

The application discloses a kind of hydrophobic drag reducer and preparation method thereof, belong to downhole working fluid technical field.Effective component of the raw material of the drag reducer made in the application, by weight fraction, includes: acrylamide 15~20 parts, acrylic acid 10~15 parts, 2-acrylamide-2-methylpropane sulfonic acid 2~3 parts, modified nanosilica 1~2 parts, initiator A 0.1~0.5 parts, chelating agent 0.5~1 parts, white oil 30~40 parts, sorbitan oleate 4~6 parts, polyoxyethylene sorbitol oleic acid ester 1~2 parts and initiator B 1~2 parts.The drag reducer of the application can reverse the wettability of rock surface to hydrophobicity, under the action of capillary force, water is difficult to enter reservoir pore, reduce the degree of shale reservoir hydration expansion, at the same time, increase the flowback rate of fracturing fluid.The application is suitable for drag reducer in shale oil and gas exploration and development.

The invention discloses a fluorescent immunoassay reagent for detecting helicobacter pylori of dogs and cats. The fluorescent immunoassay reagent comprises a kit and application of the kit. The fluorescence immunoassay reagent comprises a sample diluent; the sample diluent is prepared from 0.01 to 0.03 M of Bicine-Tris composite buffer system, 0.2 to 0.8 percent (w / v) of polyvinylpyrrolidone K40, 0.003 to 0.007 M of disodium ethylene diamine tetraacetate, 0.5 to 2 percent (w / v) of KCl, 0.5 to 2 percent (w / v) of Tween 80 and 0.1 to 1 percent (w / v) of sorbitan oleate; the pH (Potential of Hydrogen) is 6.5 to 7.8. When the fluorescent immunoassay reagent is used for detecting the helicobacter pylori of dogs and cats, various sample types can be compatible, and samples are not easy to degrade; the problem of microsphere aggregation is solved, non-specific binding is reduced, and sensitivity is improved.