Cellulose/N-isopropylacrylamide medicine controllable release hydrogel and preparation method thereof

An isopropylacrylamide and hydrogel technology, which can be applied in pharmaceutical formulations, photosplitting of drugs in the body, and medical preparations with non-active ingredients, etc., to achieve improved drug loading capacity, excellent performance, and good biocompatibility sexual effect

Active Publication Date: 2019-07-12
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few reports on the controlled release of drugs from cellulose hydrogels with both near-infrare

Method used

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  • Cellulose/N-isopropylacrylamide medicine controllable release hydrogel and preparation method thereof
  • Cellulose/N-isopropylacrylamide medicine controllable release hydrogel and preparation method thereof
  • Cellulose/N-isopropylacrylamide medicine controllable release hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) According to the mass ratio of cellulose raw material and sulfuric acid as 1:50, add cotton fiber raw material to 50wt% sulfuric acid solution, and obtain nanocellulose by ultrasonication for 3 hours at a temperature of 60°C, and dialyze the obtained nanocellulose After obtaining the nanocellulose solution;

[0028] (2) Dissolve 2.0 g of dopamine hydrochloride in 20 g of nanocellulose suspension with a mass fraction of 10.0% obtained in step (1), adjust the pH to 8.5 with hydrochloric acid, react at room temperature for 24 h, and modify the resulting After that, an appropriate amount of deionized water was added to the nanocellulose to prepare a nanocellulose solution with a mass fraction of 8.0%.

[0029] (3) Add 0.4g of N-isopropylacrylamide to 0.12g of the cellulose aqueous solution obtained in step (2), and then add 0.004g of N,N'-methylenebisacrylamide crosslinking agent, magnetic After stirring for 30-40 minutes, the near-infrared responsive cellulose / N-isoprop...

Embodiment 2

[0033] (1) According to the mass ratio of cellulose raw material and sulfuric acid as 1:50, the straw pulp fiber raw material was added to 50 wt % sulfuric acid solution, and nanocellulose was obtained by ultrasonication for 3 h at a temperature of 60 °C, and the obtained nanocellulose was Obtain nanocellulose solution after dialysis;

[0034] (2) Dissolve 2.0 g of dopamine hydrochloride in 20 g of nanocellulose suspension with a mass fraction of 10.0% obtained in step (1), adjust the pH to 8.5 with hydrochloric acid, react at room temperature for 24 h, and modify the resulting After that, an appropriate amount of deionized water was added to the nanocellulose to prepare a nanocellulose solution with a mass fraction of 8.0%.

[0035] (3) Add 0.4g of N-isopropylacrylamide to 0.4g of the cellulose solution obtained in step (2), and then add 0.004g of N,N'-methylenebisacrylamide crosslinking agent, Magnetically stirred for 30-40 minutes, the near-infrared responsive cellulose / N-...

Embodiment 3

[0039] (1) According to the mass ratio of cellulose raw material and sulfuric acid as 1:50, add microcrystalline cellulose raw material to 50 wt % sulfuric acid solution, and obtain nanocellulose by ultrasonication for 3 hours at a temperature of 60 °C, and the obtained nanofibers The nanocellulose solution is obtained after dialysis;

[0040] (2) Dissolve 2.0 g of dopamine hydrochloride in 20 g of nanocellulose suspension with a mass fraction of 10.0% obtained in step (1), adjust the pH to 8.5 with hydrochloric acid, react at room temperature for 24 h, and modify the resulting After that, an appropriate amount of deionized water was added to the nanocellulose to prepare a nanocellulose solution with a mass fraction of 8.0%.

[0041] (3) Add 0.4g of N-isopropylacrylamide to 0.8g of the cellulose solution obtained in step (2), then add 0.004g of N,N'-methylenebisacrylamide crosslinking agent, magnetic After stirring for 30-40 minutes, the near-infrared responsive cellulose / N-i...

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Abstract

The invention belongs to the technical field of cellulose hydrogel and particularly relates to a cellulose/N-isopropylacrylamide medicine controllable release hydrogel and a preparation method thereof. Dopamine is added to a cellulose solution, the surface of cellulose is modified, and the cellulose can wrap a cellulose macromolecule framework, so that the cellulose has the mechanical force reinforcement function and also has the photoresponse characteristic. Meanwhile, N-isopropylacrylamide is dispersed in the modified cellulose solution, through free radical solution polymerization, the hydrogel is formed, and accordingly the cellulose hydrogel is endowed with the near-infrared response characteristic and thermosensitivity. The nano composite hydrogel has certain potential application value in the fields of intelligent medicine control release materials and biomedical application.

Description

technical field [0001] The invention belongs to the technical field of cellulose hydrogel, and in particular relates to a cellulose / N-isopropylacrylamide drug controlled release hydrogel and a preparation method thereof. Background technique [0002] Near-infrared responsive hydrogels are a class of inorganic / organic functional composite materials that have the properties of near-infrared responsive materials, polymer materials and hydrogels. Due to its excellent near-infrared performance and biocompatibility, it has broad application prospects in the field of drug controlled release. Among them, the polymers of synthetic hydrogels include natural polymers and synthetic polymers. Because of the advantages of wide sources, low price, good biocompatibility and biodegradability, natural polymers have attracted widespread attention. [0003] Dopamine is a biomolecule with catechol and amine functional groups. Its characteristics are similar to the strong adhesion pods secreted ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/38A61K47/32A61K47/34A61K31/513A61K41/00C08F220/54C08F222/38C08B15/06
CPCA61K9/06A61K47/38A61K47/32A61K47/34A61K31/513A61K41/0042C08F220/54C08B15/06C08F222/385
Inventor 卢贝丽武羽岩林强林凤采黄彪刘杏王梓熊明诚邓秀春
Owner FUJIAN AGRI & FORESTRY UNIV
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