Polymers and oligomers with aggregation-induced emission characteristics for imaging and image-guided therapy

A technology of conjugated polymers and compositions, applied in the direction of organic active ingredients, photodissociation of drugs in the body, active ingredients of heavy metal compounds, etc., can solve problems such as affecting the effect of photodynamic therapy and weakening the ability of singlet oxygen
CN106470964AInactive Publication Date: 2017-03-01NAT UNIV OF SINGAPORE +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NAT UNIV OF SINGAPORE
Publication Date
2017-03-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

A fluorophore or conjugated polymer with aggregation-induced emission characteristics useful for drug tracking and delivery, identification and labeling of biological subjects, such as cells or parts of a cell, as well as for imaging, and image-guided photodynamic therapy are described herein.
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Description

[0001] related application

[0002] This patent application covers the US provisional patent application, application number: 61 / 984,459, filed on April 25, 2014. The contents of the patent including English are listed below.

[0003] Background of the invention

[0004] In recent decades, fluorescence imaging has been widely used in various directions of biological science research, such as programmed cell apoptosis, organelle imaging, cell lineage transmission, etc. Compared with other imaging modalities including positron emission tomography (PET), magnetic resonance imaging, single photon emission computed tomography, etc., fluorescence imaging can obtain high signal-to-noise ratio at the subcellular level by using off-the-shelf biocompatible contrast agents imaging of cells, enabling the study of cell-cell interactions and immunological studies. In these bioimaging studies, real-time non-invasive fluorescence imaging over long periods of time is crucial for the study of ...

Claims

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