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Polydopamine-coated nanometer composite photothermal reagent and preparation method thereof

A polydopamine and nanocomposite technology, which is applied in the photodissociation of drugs in the body, medical preparations containing active ingredients, drug combinations, etc., can solve the loss of morphology and optical properties, photothermal stability needs to be improved, and biological Compatibility reduction and other problems, to achieve the effects of improved physiological environment stability and photothermal stability, improved photothermal conversion efficiency, and simple operation

Inactive Publication Date: 2017-02-22
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, inorganic nanoparticles or their assemblies are easy to introduce toxic ligands during the preparation process to reduce their biocompatibility and limit their application; and inorganic nanoparticles or their assemblies are prone to aggregation due to their high specific surface area. And after heating, "melting effect" occurs and loses the original shape and optical properties, and its photothermal stability needs to be improved; in addition, in order to increase the specificity of photothermal therapy, nanomaterials need to modify some biological targeting molecules or drugs, so it is necessary to increase functional groups on the surface of nanoparticles

Method used

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  • Polydopamine-coated nanometer composite photothermal reagent and preparation method thereof
  • Polydopamine-coated nanometer composite photothermal reagent and preparation method thereof
  • Polydopamine-coated nanometer composite photothermal reagent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Use the first method to coat polydopamine shells on inorganic nanoparticles: first dissolve 1 mg of gold and silver dendritic nanoparticles to be coated in 5 mL of water, add 5 mL of 0.02 M Tris buffer solution and assist hydrochloric acid solution to adjust the pH of the reaction system to 8.5, then add 100 μL, 0.03M dopamine solution (nanoparticle: dopamine monomer concentration = 0.1 mg / mL: 0.045 mg / mL), stir at room temperature for 3 hours, then centrifuge the above solution to obtain polydopamine-coated Nanocomposite photothermal reagent; the thickness of the polydopamine shell is 6nm, and the surface plasmon resonance peak after coating the polydopamine shell is 811nm (the dopamine coated on the surface of the nanoparticles only accounts for a small part of the input dopamine, and the mass is very small, relatively negligible compared to inorganic nanoparticles).

[0035] The size of the gold and silver dendritic nanoparticles is about 135nm, and the plasmon reson...

Embodiment 2

[0037] The first method is used to coat the polydopamine shell layer on the inorganic nanoparticles: first, 1 mg of gold and silver dendritic nanoparticles described in Example 1 to be coated are dissolved in 5 mL of water, and 5 mL of 0.02 M Tris buffer solution is added and assisted Hydrochloric acid solution adjusts the pH of the reaction system to 8.5 (the buffer solution only provides an alkaline environment and does not participate in the reaction), and then adds 200 μL, 0.03M dopamine solution (nanoparticle: dopamine monomer concentration = 0.1 mg / mL: 0.090 mg / mL ), stirred at room temperature for 3 hours, then centrifuged the above solution to separate and obtain the nanocomposite photothermal reagent coated with polydopamine; the thickness of the polydopamine shell was 10nm, and the surface plasmon resonance peak after coating the polydopamine shell was 817nm.

Embodiment 3

[0039] The first method is used to coat the polydopamine shell layer on the inorganic nanoparticles: first, 1 mg of gold and silver dendritic nanoparticles described in Example 1 to be coated are dissolved in 5 mL of water, and 5 mL of 0.02 M Tris buffer solution is added and assisted Hydrochloric acid solution adjusts the pH of the reaction system to 8.5 (the buffer solution only provides an alkaline environment and does not participate in the reaction), and then adds 600 μL, 0.03M dopamine solution (nanoparticle: dopamine monomer concentration=0.1mg / mL: 0.260mg / mL ), stirred at room temperature for 3 hours, then centrifuged the above solution to separate and obtain a nanocomposite photothermal reagent coated with polydopamine; the thickness of the polydopamine shell was 34nm, and the surface plasmon resonance peak after coating the polydopamine shell was 917nm.

[0040] Examples 1 to 3 illustrate that the first method is used to coat polydopamine shells on the surface of gold...

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Abstract

The invention relates to a polydopamine-coated nanometer composite photothermal reagent and a preparation method thereof and belongs to the technical field of function materials. The method is simple to operate and two coating methods are provided: firstly, inorganic nanometer particles or the surface of an assembly of the inorganic nanometer particles are directly coated with a polydopamine shell layer through the oxidative polymerization character of a dopamine monomer; and secondly, nanometer particles are synthesized and coated by one step by utilizing the reducibility and the oxidative polymerization character of dopamine, so that the trouble of synthesizing the nanometer particles in advance is prevented, operation is more simple, and a synthesis method has better green environmental protection character. Proved by experiments, after the nanometer particles are coated with the polydopamine shell layer, the biocompatibility, the physiological environment stability and the photothermal stability of the nanometer particles are greatly improved; by introducing a hydroxyl functional group and an amino functional group, the condition of further modifying a biological targeting matter or a loaded medicine is supplied for the nanometer particles; and in addition, as the polydopamine has the photothermal character, the photothermal conversion efficiency of a material coated with the polydopamine shell layer is improved.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a polydopamine-coated nanocomposite photothermal reagent and a preparation method thereof. Background technique [0002] In order to avoid the side effects of traditional treatment methods for cancer patients, photothermal therapy has attracted the attention of researchers. Photothermal therapy refers to a new and highly specific tumor treatment method in which photothermal reagents absorb near-infrared light and quickly convert it into heat, which heats up the system, causes protein denaturation, and ultimately kills cancer cells. There are many kinds of photothermal reagents, which are mainly divided into inorganic nanoparticles or their assemblies and organic polymer nanoparticles. Among them, inorganic nanoparticles or their assemblies are simple in preparation method, controllable in shape, and have relatively good properties in the near-infrared reg...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/34A61K9/51A61P35/00
CPCA61K41/0052A61K9/5146A61K41/0042
Inventor 张皓王文婧李晶杨柏
Owner JILIN UNIV
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