Preparing method of carboxymethyl chitosan/graphene oxide/poly(N-isopropylacrylamide) nanocomposite hydrogel

Abstract

The invention relates to a preparing method of carboxymethyl chitosan / graphene oxide / poly(N-isopropylacrylamide) nanocomposite hydrogel. In preparation, the method includes the steps of conducting even mixing to obtain carboxymethyl chitosan / graphene oxide / N-isopropylacrylamide dispersion liquid containing photoinitiator, adding an activating agent to obtain a mixed solution, making the mixed solution react under the room temperature and nitrogen protection conditions to obtain carboxymethyl chitosan / graphene oxide crosslinked and cured hydrogel, and finally conducting ultraviolet irradiationto obtain the carboxymethyl chitosan / graphene oxide / poly(N-isopropylacrylamide) nanocomposite hydrogel. The finally prepared nanocomposite hydrogel has the pH / temperature dual-response characteristic, has the water content of 80-92%, the maximum compressive strength of 0.6-0.8 MPa and the fracture strain of 75-85%, has the advantage of good biocompatibility, and has potential application value inthe fields of drug release, molecular devices and the like.

Description

technical field

[0001] The invention belongs to the field of polymer materials and relates to a preparation method of carboxymethyl chitosan / graphene oxide / poly(N-isopropylacrylamide) nanocomposite hydrogel. Background technique

[0002] Hydrogel is a kind of material made of a kind of hydrophilic cross-linked polymer three-dimensional network structure that can absorb a large amount of water and is insoluble in water. Due to its excellent biomimetic properties and biocompatibility, It has a wide range of applications in biomedical fields such as drug release, tissue engineering, and wound dressings. According to the different responses of hydrogels to external stimuli, they can be divided into two categories: traditional hydrogels and smart hydrogels. Among them, traditional hydrogels are insensitive to external responses, while smart hydrogels can sense the external environment. Subtle changes in ions, such as changes in temperature, pH, light, electric field, magnetic fi...