Injectable organosilicone/chitosan nanocomposite hydrogel as well as preparation method and application thereof

A chitosan nano-composite hydrogel technology, which is applied in the fields of pharmaceutical formula, medical science, prosthesis, etc., can solve the problems of poor mechanical strength and achieve the effect of improving mechanical strength
CN108404221AInactive Publication Date: 2018-08-17ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
Publication Date
2018-08-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses injectable organosilicone / chitosan nanocomposite hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: selecting water-soluble aminated polyhedral oligomeric silsesquioxane (POSS); uniformly mixing the POSS with a chitosan solution; mixing the mixture with a second macromolecular aqueous solution carrying analdehyde group; carrying out a Schiff base reaction on amino groups contained in the POSS and chitosan and aldehyde-based macromolecules in order to generate the organosilicone / chitosan nanocompositehydrogel. The POSS is dispersed uniformly in a chitosan system. The organosilicone / chitosan nanocomposite hydrogel prepared by the invention has reversible response to pH, has mechanical property being greatly improved compared with the traditional chitosan hydrogel, and has injectability and self-healing performance. The preparation method and process of the hydrogel are simple, and no toxic organic small molecular crosslinking agent is used. The hydrogel is environmentally friendly, is suitable for large-scale preparation and can be applied in the field of biomedical materials.
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Description

technical field

[0001] The invention belongs to the technical field of new materials, and in particular relates to an organosilicon / chitosan nanocomposite hydrogel and its preparation method and application. Background technique

[0002] Injectable hydrogels are formed in situ in vivo, are equivalent to extracellular matrix in nature, can reach very deep tissue defects, are minimally invasive and provide good defect edge adaptation, which can avoid surgical procedures. It is highly traumatic and plays a role in reducing the risk of infection, accelerating wound healing, reducing patient pain and reducing surgical costs. At present, injectable hydrogels are mainly prepared by chemical cross-linking and physical cross-linking. Compared with chemical cross-linking, physical cross-linking forms a gel through the interaction force between molecules, and does not involve chemical reactions, so it is more efficient. Easy and safe. However, the disadvantage of physically cross-lin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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