Injectable organosilicone/chitosan nanocomposite hydrogel as well as preparation method and application thereof

A chitosan nano-composite hydrogel technology, which is applied in the fields of pharmaceutical formula, medical science, prosthesis, etc., can solve the problems of poor mechanical strength and achieve the effect of improving mechanical strength

Inactive Publication Date: 2018-08-17
ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantage of physically cross-linked injectable hydrogels is poor mechanical strength

Method used

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  • Injectable organosilicone/chitosan nanocomposite hydrogel as well as preparation method and application thereof
  • Injectable organosilicone/chitosan nanocomposite hydrogel as well as preparation method and application thereof
  • Injectable organosilicone/chitosan nanocomposite hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Octapolyammonium chloride propyl polysilsesquioxane (OCAPS): 30 mL of 3-aminopropyltriethoxysilane (KH550) and 27 mL of concentrated hydrochloric acid were sequentially added to 200 mL of anhydrous methanol In a single-necked bottle, magnetically stirred at room temperature, a white precipitate was produced during the reaction, and after one week, the resulting product was suction filtered, 40 o C was dried in vacuum for 24 hours to obtain water-soluble POSS, namely octamer ammonium chloride propyl polysilsesquioxane (OCAPS).

Embodiment 2

[0021] CS / HPC / OCAPS 2.50 The preparation of nanocomposite hydrogel: take by weighing 0.20g chitosan and be dissolved in 4ml mass fraction and be 1% in the acetic acid solution of mass fraction, be mixed with the chitosan acetic acid solution that mass fraction is 5%, add to the chitosan acetic acid solution then Add 0.10g of OCAPS; weigh 0.30g of hydroxypropyl cellulose and dissolve it in 4ml of deionized water until it is completely dissolved, then mix the fully dissolved hydroxypropyl cellulose solution with chitosan solution evenly, 37 o C A ternary composite hydrogel was prepared by reacting in a constant temperature water bath for 24 hours.

[0022] CS / HPC / OCAPS of this embodiment 2.50 Nanocomposite hydrogel, wherein the meaning of 2.50 refers to the mass fraction of OCAPS in the chitosan-acetic acid solution, that is, 2.5wt%, the same below.

Embodiment 3

[0024] CS / HPC / OCAPS 3.75 Preparation of nanocomposite hydrogel: Weigh 0.2g chitosan and dissolve it in 4ml acetic acid solution with a mass fraction of 1wt%, to prepare a chitosan acetic acid solution with a mass fraction of 5 wt%, and then add chitosan acetic acid solution Add 0.15g of OCAPS to it. Weigh 0.3g of formylated hydroxypropyl cellulose and dissolve it in 4ml of deionized water until it is completely dissolved, then mix the fully dissolved formylated hydroxypropyl cellulose solution and chitosan solution evenly, 37 o C A ternary composite hydrogel was prepared by reacting in a constant temperature water bath for 24 hours.

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Abstract

The invention discloses injectable organosilicone / chitosan nanocomposite hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: selecting water-soluble aminated polyhedral oligomeric silsesquioxane (POSS); uniformly mixing the POSS with a chitosan solution; mixing the mixture with a second macromolecular aqueous solution carrying analdehyde group; carrying out a Schiff base reaction on amino groups contained in the POSS and chitosan and aldehyde-based macromolecules in order to generate the organosilicone / chitosan nanocompositehydrogel. The POSS is dispersed uniformly in a chitosan system. The organosilicone / chitosan nanocomposite hydrogel prepared by the invention has reversible response to pH, has mechanical property being greatly improved compared with the traditional chitosan hydrogel, and has injectability and self-healing performance. The preparation method and process of the hydrogel are simple, and no toxic organic small molecular crosslinking agent is used. The hydrogel is environmentally friendly, is suitable for large-scale preparation and can be applied in the field of biomedical materials.

Description

technical field [0001] The invention belongs to the technical field of new materials, and in particular relates to an organosilicon / chitosan nanocomposite hydrogel and its preparation method and application. Background technique [0002] Injectable hydrogels are formed in situ in vivo, are equivalent to extracellular matrix in nature, can reach very deep tissue defects, are minimally invasive and provide good defect edge adaptation, which can avoid surgical procedures. It is highly traumatic and plays a role in reducing the risk of infection, accelerating wound healing, reducing patient pain and reducing surgical costs. At present, injectable hydrogels are mainly prepared by chemical cross-linking and physical cross-linking. Compared with chemical cross-linking, physical cross-linking forms a gel through the interaction force between molecules, and does not involve chemical reactions, so it is more efficient. Easy and safe. However, the disadvantage of physically cross-lin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/44C08J3/075C08L83/08C08L5/08C08L5/04C08L1/28C08L5/02C08L3/04
CPCA61L27/44A61L27/52A61L2400/06C08J3/075C08J2301/28C08J2303/04C08J2305/02C08J2305/04C08J2405/08C08J2483/08C08L5/08
Inventor 张晓静杨皓然窦竞成沈炜炜方少明
Owner ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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