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Polyurethane adhesive containing catechol group as well as preparation method and application of polyurethane adhesive

A catechol and adhesive technology, which is applied in the field of polyurethane adhesive and its preparation, can solve the problems of underwater adhesion performance and biocompatibility, etc.

Active Publication Date: 2022-03-29
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problem that the existing medical adhesives are difficult to have both underwater adhesion performance and biocompatibility, the purpose of the present invention is to provide an adhesive with excellent underwater adhesion performance and biocompatibility, which can quickly seal the wound medical adhesive

Method used

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  • Polyurethane adhesive containing catechol group as well as preparation method and application of polyurethane adhesive
  • Polyurethane adhesive containing catechol group as well as preparation method and application of polyurethane adhesive
  • Polyurethane adhesive containing catechol group as well as preparation method and application of polyurethane adhesive

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Experimental program
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Effect test

Embodiment 1

[0060] Embodiment 1, the preparation of adhesive system and adhesive of the present invention

[0061] 1. According to the mass fraction in Table 2, LDA-2HCl, L 3 DA-4HCl is dissolved in water containing triethanolamine to form a solution (triethanolamine has two effects: 1, for removing LDA and L 3 DA combined hydrochloride; 2, increase the viscosity of the solution).

[0062] 2. Take the prepolymer A and heat it to 30°C to melt into a liquid state, and mix it with the solution prepared in step 1, which is the adhesive system of the present invention. It is the adhesive of the present invention when it is left to stand for 10 seconds to solidify. According to L 3 Five different adhesives were obtained with different DA content, namely UWA-0, UWA-1, UWA-2, UWA-3, UWA-4.

[0063] Formulation (mass fraction wt%) of table 2 underwater adhesive (UWAs)

[0064]

Embodiment 2

[0065] Embodiment 2, the preparation of adhesive system and adhesive of the present invention

[0066] Use prepolymer B, LDA-2HCl, L 3 The consumption of DA-4HCl, prepolymer, water and triethanolamine is different from Example 1, and the mass fraction of consumption is as follows: LDA-2HCl 15.36wt%, prepolymer B 64.21wt%, water 7.50wt%, triethanolamine 12.93wt% ; All the other preparation method steps are with reference to embodiment 1.

[0067] The bonding strength of the prepared adhesive DMPUA-1 to titanium material is 210.5kPa (dry state); 90.3kPa (underwater); the bonding strength to pigskin is 16.0kPa (dry state); 9.2kPa (water Down)

Embodiment 3

[0068] Embodiment 3, the preparation of adhesive system and adhesive of the present invention

[0069] Use prepolymer B, LDA-2HCl, L 3 The consumption of DA-4HCl, prepolymer, water and triethanolamine is different from embodiment 1, and consumption mass fraction is as follows: LDA-2HCl 14.80wt%, L 3 DA-4HCl 0.55wt%, prepolymer B 64.22wt%, water 7.50wt%, triethanolamine mass fraction 12.93wt%; the rest of the preparation method steps refer to Example 1.

[0070] The bonding strength of the prepared adhesive DMPUA-2 to titanium material is 630.7kPa (dry state), 230.1kPa (underwater); the bonding strength to pigskin is 52.7kPa (dry state), 39.1kPa (water Down).

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Abstract

The invention relates to a polyurethane adhesive containing catechol groups as well as a preparation method and application of the polyurethane adhesive. The invention provides a bonding system which is prepared from the following components in percentage by mass: 60 to 65 percent of isocyanato-terminated polyurethane prepolymer, 10 to 18 percent of micromolecular polyamine containing catechol groups and the balance of solvent. The invention also provides an adhesive with excellent bonding capacity and a preparation method thereof. The preparation method comprises the following steps: uniformly mixing the components of the adhesive system, and standing to react for several seconds. The adhesive disclosed by the invention has excellent adhesion capacity on various materials such as biological tissues, metals and ceramics in a dry environment and underwater, and has a wide application prospect. Meanwhile, the adhesive disclosed by the invention is good in biocompatibility, can promote endogenous blood coagulation, and has the potential of serving as a medical hemostatic and a tissue adhesive.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a polyurethane adhesive containing catechol groups, a preparation method and application thereof. Background technique [0002] Surgical sutures have long been widely used as wound closure materials in surgical procedures because of their low cost and easy storage. However, in practical application, it has defects such as causing secondary infection to the surrounding tissue, being unable to quickly seal the wound, and requiring high operating skills for doctors. Therefore, in recent years, researchers have become more and more interested in using medical adhesives instead of surgical sutures to achieve hemostasis and wound closure. [0003] Commonly used medical adhesives are mainly divided into three categories: synthetic polymer adhesives, protein adhesives, and polysaccharide adhesives, some of which have been used clinically (such as fibrin adhesives); howeve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J175/08C09J175/04C08G18/66C08G18/48C08G18/42C08G18/32C08G18/12C08G18/10A61L24/04A61L24/00
CPCC09J175/08C09J175/04C08G18/10C08G18/12C08G18/4833C08G18/4277C08G18/428C08G18/4018C08G18/6688A61L24/046A61L24/001A61L24/0042A61L2400/06A61L2400/04C08L75/04C08L75/08C08G18/3275
Inventor 罗锋谭鸿赵鑫明浩李洁华李震
Owner SICHUAN UNIV
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