Ion type nano-composite hydrogel and preparation method thereof

A nanocomposite and hydrogel technology, which is applied in the field of preparation of ionic nanocomposite hydrogels, can solve problems such as reports, and achieve the effects of simple preparation process, easy control and good mechanical properties.

Inactive Publication Date: 2012-01-18
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] So far, there are no patents and literature reports on t

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 2ml of laponite solution with a concentration of 5% by mass and 2ml of gelatin solution with a concentration of 5% by mass and mix them in a 10ml centrifuge tube to form a uniform transparent solution, add 0.25g of acrylamide monomer, blow in nitrogen, and stir for 10 minutes. Then add 44 μl of N,N-methylenebisacrylamide solution with a mass percentage concentration of 1.25%, and 125 μl of a 10% mass percentage concentration of N,N,N',N'-tetramethylethylenediamine solution, and mix well Continue to pass nitrogen gas for 5 minutes, then add 110 μl of ammonium persulfate solution with a mass percentage concentration of 0.4%, and then quickly seal it, place it in a water bath at 20°C and react for 24 hours, take out the reactant and cut it into sections, and soak it in deionized water at 50°C for 48 hours. Hours, change the deionized water every 8 hours to obtain a nanocomposite hydrogel with good elasticity, transparency and high biocompatibility.

Embodiment 2

[0028] Take 3ml of 5% Laponite solution and 1ml of 5% gelatin solution in a 10ml centrifuge tube and mix to form a uniform transparent solution, add 0.25g of acrylamide monomer, blow in nitrogen, and stir for 15 minutes. Then add 44 μl of N,N-methylenebisacrylamide solution with a mass percentage concentration of 1.25%, and 125 μl of a 10% mass percentage concentration of N,N,N',N'-tetramethylethylenediamine solution, and mix well Continue to pass nitrogen gas for 5 minutes, then add 110 μl of ammonium persulfate solution with a mass percentage concentration of 0.4%, and then quickly seal it, place it in a water bath at 20°C for 24 hours, take out the reactant and cut it into sections, soak it in deionized water at 40°C for 48 Hours, change the deionized water every 8 hours to obtain a nanocomposite hydrogel with good elasticity, transparency and high biocompatibility.

Embodiment 3

[0030]Take 1ml of laponite solution with a concentration of 5% by mass and 3ml of gelatin solution with a concentration of 5% by mass and mix them in a 10ml centrifuge tube to form a uniform transparent solution, add 0.25g of acrylamide monomer, blow in nitrogen, and stir for 10 minutes. Then add 44 μl of N,N-methylenebisacrylamide solution with a mass percentage concentration of 1.25%, and 125 μl of a 10% mass percentage concentration of N,N,N',N'-tetramethylethylenediamine solution, and mix well Continue to pass nitrogen gas for 5 minutes, then add 110 μl of ammonium persulfate solution with a mass percentage concentration of 0.4%, and then quickly seal it, and place it in a water bath at 20°C for 24 hours. Hours, change the deionized water every 8 hours to obtain a nanocomposite hydrogel with good elasticity, transparency and high biocompatibility.

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Abstract

The invention provides an ion type nano-composite hydrogel and a preparation method thereof. The preparation method comprises the following steps of: dissolving acrylamide monomer, nano inorganic clay and gelatin in deionized water, stirring for 10 to 30 minutes in an inert atmosphere; adding auxiliary cross-linking agent and catalyst, stirring for 5 to 10 minutes in the inert atmosphere, and then adding an initiating agent; carrying out a free radical polymerization for 12 to 36 hours at a temperature of 0 to 30 DEG C; immersing reaction product in the deionized water at the temperature of 20 to 60 DEG C, changing deionized water at regular intervals of 5 to 8 hours, continuing for 48 to 72 hours to obtain the ion type nano-composite hydrogel. The preparation method has simple process and controllable condition; the prepared gel has excellent biocompatibility, mechanical property and optical property, and can be widely used in the field of tissue engineering.

Description

technical field [0001] The invention relates to a preparation method of a hydrogel, in particular to a preparation method of an ionic nanocomposite hydrogel. Background technique [0002] Hydrogel is a polymer material similar to living tissue. It is composed of a polymer network that is insoluble in water but swellable and water. , Widely used in biomedical fields such as biological scaffolds, cell culture, drug controlled release, tissue engineering and trauma, burn treatment and hemostasis. However, the fragile mechanical properties of hydrogels restrict their further applications. The birth of nanocomposite hydrogels overcomes the shortcomings of traditional hydrogels and brings breakthroughs in this field. Nanocomposite hydrogels are prepared by in-situ free radical polymerization with inorganic nanoparticles as physical crosslinking agents and monomers under mild conditions (room temperature, without stirring). Because of the unique organic (polymer) / inorganic (nano...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L33/26C08L89/00C08K3/34C08F120/56C08F2/44
Inventor 林炜李昌朋穆畅道李德富
Owner SICHUAN UNIV
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