Bioactive nano composite PVA-hydroxyapatite aquagel and its prepn.

Abstract

The invention refers to a kind of nano complex water gel of bioactive polyvinyl alcohol / the oxhydryl apatite and preparation method which is as follows: prepare the PVA solution by using the purified polyvinyl alcohol; add the grinded and sifted Ca(OH)2 to the pure anhydrous alcohol, then heat the mixture and ultrasonically disperse it to get the alcohol-calcium suspended liquid (or add the metal calcium to the anhydrous alcohol, stir them and make them react to get the calcium alcohol solution); mix said two solutions; then add anhydrous alcohol containing H3PO4 to the mixed solution, and by freezing-melt molding, get the naneo complex water gel of bioactive polyvinyl alcohol. The invention utilizes the hydrophilicity of water-soluble polymer and the static acting force of oxhydryl to make the surface of the generative HA wetting and evenly dispersing.

Description

(1) Technical field

[0001] The invention relates to the technical field of biomedical composite materials, in particular to a bioactive polyvinyl alcohol / hydroxyapatite nanocomposite hydrogel and a preparation method thereof. (2) Background technology

[0002] Polyvinyl alcohol (PVA) hydrogel is a water-swellable body of network structure formed by cross-linking hydrophilic polyvinyl alcohol macromolecules. The PVA hydrogel formed by a certain process is characterized by its high elasticity and chemical stability. , easy to form, non-toxic and side effects and good compatibility with human tissue, it has obtained many uses in biomedicine. The physical properties of PVA hydrogel materials are closer to living tissues than any other synthetic materials, and its expansion characteristics and permeability to water molecules make it excellent in biocompatibility; and its good flexibility and high elasticity can Reduce mechanical stimulation to surrounding cells and tissues. The...