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Bioactive nano composite PVA-hydroxyapatite aquagel and its prepn.

A technology of hydroxyapatite and polyvinyl alcohol, which is applied in the field of biomedical composite materials, can solve the problems of decreased mechanical properties and biological activity of composite hydrogels, uneven dispersion of HAP ultrafine particles, and unsolved problems. , to achieve the effect of high mechanical properties, avoiding agglomeration and high biological activity

Inactive Publication Date: 2003-01-08
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the composite hydrogel obtained by the commonly used physical mixing method and precipitation method, the dispersion of HAP is extremely uneven, and the highly surface-active nanoparticles are seriously agglomerated in the matrix, which makes the mechanical properties of the PVA / HAP composite hydrogel and the biological activity is greatly reduced
How to overcome the agglomeration and uneven dispersion of HAP ultrafine particles in the hydrogel matrix is ​​the key technology for the preparation of high-performance bioactive artificial cartilage implants. At present, this problem has not been well resolved at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The first step is to dissolve polyvinyl alcohol in distilled water at 90°C after refining and purification, and prepare a PVA aqueous solution with a concentration of 15% by weight;

[0016] The second step will analyze pure Ca(OH) 2 After fully grinding and sieving, add absolute ethanol, ultrasonically disperse for 30 minutes, and heat at 80°C for 5 minutes to prepare an ethanol-calcium suspension with a solid content of 4%;

[0017] Step 3 In a constant temperature water bath at 75°C, under vigorous stirring, pour the solution obtained in the second step into the solution obtained in the first step, and stir thoroughly for 3 hours until the dispersion is uniform;

[0018] The fourth step is to obtain refined H according to the Ca / P ratio of 1.67 3 PO 4 , added to absolute ethanol to prepare a solution with a weight percentage of 10%. After shaking and stirring evenly, slowly add it dropwise to the solution obtained in the third step with a separatory funnel, and rea...

Embodiment 2

[0022] The first step is to dissolve polyvinyl alcohol in 95°C distilled water after refining and purifying, and prepare a PVA aqueous solution with a concentration of 15% by weight;

[0023] In the second step, metal Ca was dropped into absolute ethanol at 80° C. under nitrogen protection, and stirred for 4 hours to obtain a calcium ethoxide solution with a concentration of 7% by weight;

[0024] In the third step, in a constant temperature water bath at 90°C, pour the solution obtained in the second step into the solution obtained in the first step, and stir thoroughly for 3 hours until the mixture is uniform;

[0025] The fourth step is to prepare 6% H with a concentration of 6% by weight according to the Ca / P ratio of 1.67. 3 PO 4 - Dehydrated ethanol solution, slowly added dropwise to the solution obtained in the third step, and stirred, fully reacted at 90°C for 8 hours, to obtain a PVA aqueous solution in which HAP was uniformly dispersed;

[0026] The fifth step is t...

Embodiment 3

[0029] The first step is to dissolve the polyvinyl alcohol in distilled water at 85°C after refining and purifying, and prepare an aqueous PVA solution with a concentration of 18% by weight;

[0030] The second step will analyze pure Ca(OH) 2 After fully grinding and sieving, add absolute ethanol, ultrasonically disperse for 60 minutes, and heat at 60°C for 15 minutes to prepare an ethanol-calcium suspension with a solid content of 10%;

[0031] Step 3 In a constant temperature water bath at 80°C, under vigorous stirring, pour the solution obtained in the second step into the solution obtained in the first step, and stir thoroughly for 2 hours until the dispersion is uniform;

[0032] The fourth step is to prepare 15% H with a weight percent concentration of 2.0 according to the Ca / P ratio. 3 PO 4 - Anhydrous ethanol solution, shake and stir evenly, slowly add dropwise to the solution obtained in the third step with a separatory funnel, and react at 70°C for 20 hours under f...

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PUM

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Abstract

The invention refers to a kind of nano complex water gel of bioactive polyvinyl alcohol / the oxhydryl apatite and preparation method which is as follows: prepare the PVA solution by using the purified polyvinyl alcohol; add the grinded and sifted Ca(OH)2 to the pure anhydrous alcohol, then heat the mixture and ultrasonically disperse it to get the alcohol-calcium suspended liquid (or add the metal calcium to the anhydrous alcohol, stir them and make them react to get the calcium alcohol solution); mix said two solutions; then add anhydrous alcohol containing H3PO4 to the mixed solution, and by freezing-melt molding, get the naneo complex water gel of bioactive polyvinyl alcohol. The invention utilizes the hydrophilicity of water-soluble polymer and the static acting force of oxhydryl to make the surface of the generative HA wetting and evenly dispersing.

Description

(1) Technical field [0001] The invention relates to the technical field of biomedical composite materials, in particular to a bioactive polyvinyl alcohol / hydroxyapatite nanocomposite hydrogel and a preparation method thereof. (2) Background technology [0002] Polyvinyl alcohol (PVA) hydrogel is a water-swellable body of network structure formed by cross-linking hydrophilic polyvinyl alcohol macromolecules. The PVA hydrogel formed by a certain process is characterized by its high elasticity and chemical stability. , easy to form, non-toxic and side effects and good compatibility with human tissue, it has obtained many uses in biomedicine. The physical properties of PVA hydrogel materials are closer to living tissues than any other synthetic materials, and its expansion characteristics and permeability to water molecules make it excellent in biocompatibility; and its good flexibility and high elasticity can Reduce mechanical stimulation to surrounding cells and tissues. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/00C08K3/32C08L29/04
Inventor 郑裕东王迎军刘青朱晓丽吴刚
Owner SOUTH CHINA UNIV OF TECH
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