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PVA (polyvinyl alcohol) composite aquagel with bioactivity and preparation method thereof

A technology of compounding hydrogel and polyvinyl alcohol is applied in the field of biomedical composite materials, which can solve the problems of improving the surface friction of artificial cartilage, and achieve the effects of low cost, mild reaction conditions and reducing friction.

Inactive Publication Date: 2012-08-15
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the introduction of HA can promote the growth of bone tissue into the gel, form a firm biological bond and osseointegration, effectively prevent the movement and dislocation of the implanted cartilage material, and improve the stability of the artificial cartilage prosthesis, but at the same time it improves the artificial cartilage. Surface friction, causing more wear
How to improve the mechanical strength of PVA hydrogel and endow it with biological activity while still maintaining the excellent low-friction behavior of PVA hydrogel has not been well solved at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) 10 g of PVA with a degree of polymerization of 1750 and a degree of hydrolysis of 95% was dissolved in 60 g of deionized water at 90° C. The number average molecular weight of 0.15g is 2×10 6 Add the PEO in 2ml of ethanol for preliminary dispersion, then add 30g of deionized water, stir at 60°C, and dissolve. Mix the PVA aqueous solution and the PEO solution, and stir thoroughly for 10 hours until the two are evenly mixed to form a transparent and uniform solution.

[0028] (2) Ca(OH) 2 Grind and sieve, take 1 g, add to 10 ml of absolute ethanol, ultrasonically disperse for 30 minutes, and heat at 70° C. for 5 minutes to prepare a suspension of Ca in absolute ethanol.

[0029] (3) Add the suspension of (2) into the mixed solution of (1) under vigorous stirring in a constant temperature water bath at 80°C, and stir thoroughly for 4 hours until the dispersion is uniform.

[0030] (4) Take refined H according to Ca / P ratio of 1.6 3 PO 4 , formulated to a concentra...

Embodiment 2

[0034] (1) 6 g of PVA with a degree of polymerization of 6000 and a degree of hydrolysis of 88% was dissolved in 64 g of deionized water at 90° C. The number average molecular weight of 0.1g is 2×10 6 Add the PEO in 2ml of ethanol for preliminary dispersion, then add 30g of deionized water, stir at 60°C, and fully dissolve. Mix the PVA solution and the PEO solution and stir thoroughly for 10 hours until the two are evenly mixed to form a transparent and homogeneous solution.

[0035] (2) Ca(OH) 2 Grind and sieve, take 2 g, add 10 ml of absolute ethanol, ultrasonically disperse for 30 minutes, and heat at 70°C for 5 minutes to prepare a Ca-ethanol suspension.

[0036] (3) Add the suspension of (2) into the mixed solution of (1) under vigorous stirring in a constant temperature water bath at 80°C, and stir thoroughly for 4 hours until the dispersion is uniform.

[0037] (4) Take refined H according to Ca / P ratio of 1.6 3 PO 4 , formulated to a concentration of 15% H 3 PO 4 ...

Embodiment 3

[0041] (1) 10 g of PVA with a degree of polymerization of 1750 and a degree of hydrolysis of 95% was dissolved in 64 g of deionized water at 90° C. The number average molecular weight of 0.15g is 8×10 5 Add the PEO in 2ml of ethanol for preliminary dispersion, then add 30g of deionized water, stir at 60°C, and fully dissolve. Mix the PVA solution and the PEO solution and stir thoroughly for 10 hours until the two are evenly mixed to form a transparent and homogeneous solution.

[0042] (2) Ca(OH) 2 Grind and sieve, take 0.5g, add 10ml of absolute ethanol, ultrasonically disperse for 30 minutes, and heat at 70°C for 5min to prepare a Ca-ethanol suspension.

[0043] (3) Add the suspension of (2) into the mixed solution of (1) under vigorous stirring in a constant temperature water bath at 80°C, and stir thoroughly for 4 hours until the dispersion is uniform.

[0044] (4) Take refined H according to Ca / P ratio of 1.5 3 PO 4 , formulated to a concentration of 10% H 3 PO 4 T...

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Abstract

The invention discloses a PVA (polyvinyl alcohol) composite aquagel with bioactivity and a preparation method thereof. The preparation method comprises the following steps: mixing a PVA water solution and a PEO (polyoxyethylene) solution, adding a Ca-ethanol suspension or calcium ethoxide solution, adding anhydrous alcohol containing H3PO4, freezing, and defreezing to obtain the PVA composite aquagel with bioactivity. The invention has the advantages of no biotoxicity of raw materials, low cost, mild reaction conditions, and safe and simple technique, and satisfies the environmental requirements; high number-average molecular weight PEO with favorable biocompatibility and lubricating property is introduced into a nano HA / PVA composite aquagel, so the high number-average molecular weight PEO molecular chain forms polymer brushes on the aquagel surface to lower the friction force of the aquagel surface; and thus, the material can be conveniently applied to joint prosthesis cartilage replacement materials.

Description

technical field [0001] The invention relates to the technical field of biomedical composite materials, in particular to a bioactive polyvinyl alcohol composite hydrogel and a preparation method thereof. Background technique [0002] Polyvinyl alcohol (PVA) hydrogel is a water-swelling body of network structure formed by the cross-linking of hydrophilic polyvinyl alcohol macromolecules. The PVA hydrogel formed by a certain process is characterized by its stable chemical properties , good physical and mechanical properties, easy molding, no toxic side effects, good biocompatibility with human tissues, and has been used in many applications. Especially in the field of biomedicine, the physical properties of PVA hydrogel materials are closer to living tissues than any other synthetic materials, excellent permeability to water molecules, suitable expansion, good flexibility and other properties are used for Such as burn or trauma treatment, plastic surgery, slow-release drug car...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L29/04C08L71/02C08K3/32A61L27/26A61L27/52
Inventor 杜淼丁维郑强
Owner ZHEJIANG UNIV
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