Medical beta-titanium alloy composite material with osteogenesis inducing activity and preparation method thereof

A technology of β-titanium alloy and composite materials, applied in electrolytic coatings, medical science, surface reaction electrolytic coatings, etc., can solve the problems of high manufacturing costs, achieve improved interface adhesion work, ultra-low elastic modulus, and production efficiency high effect
CN103357070AActive Publication Date: 2013-10-23HEBEI UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HEBEI UNIV OF TECH
Publication Date
2013-10-23

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Abstract

The invention relates to a medical beta-titanium alloy composite material with osteogenesis inducting activity and a preparation method thereof. The material comprises a base material and a titanium oxide nano-tube array layer, which is generated in-situ and attached to the surface of the base material and contains BMP-2 cell growth factors. The base material is a medical beta-titanium alloy of the Ti-25Nb-6Zr-xMo family, wherein the x is between 2 and 5. The diameters of nano-tubes, which are generated in-situ on the alloy surface, are between 30 and 50 nm, the lengths of the nano-tubes are between 200 and 300 nm, and the nano-tubes are arranged in arrays and perpendicular to the surface of the titanium alloy. The medical beta-titanium alloy composite material has ultra-low elastic modulus and is capable of forming better interface mechanic matching with the bone tissue. So osteoblasts grow rapidly along the wall on the surface of medical beita-titanium alloy whose surface is loaded with titanium oxide nano-tube biological composite material containing BMP-2, and proliferate obviously. The composite material has a good effect on inducing osteoblasts to proliferate to form bone matrix and can be used to bone replacement or repairing.
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Description

technical field

[0001] The technical solution of the invention relates to the nanometerization and surface activation of the medical β-titanium alloy, in particular to the medical β-titanium alloy composite material with osteogenic activity and its preparation method. Background technique

[0002] Titanium and its alloys have become the first choice for biomedical metal materials due to their excellent biocompatibility and mechanical adaptability, among which medical β titanium alloy has lower elastic modulus, better biocompatibility, wear resistance and corrosion resistance And formability, and no potential toxic elements exist, so it is more suitable for use as implant material. With the development of nanotechnology and nanofabrication technology, it has become one of the research hotspots to improve the biocompatibility and bioactivity of medical titanium alloy surface by nano-modification. As an implant material, the nano-biological layer on the surface of titanium all...

Claims

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