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Medical beta-titanium alloy composite material with osteogenesis inducing activity and preparation method thereof

A technology of β-titanium alloy and composite materials, applied in electrolytic coatings, medical science, surface reaction electrolytic coatings, etc., can solve the problems of high manufacturing costs, achieve improved interface adhesion work, ultra-low elastic modulus, and production efficiency high effect

Active Publication Date: 2013-10-23
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method of the present invention overcomes the disadvantages of high manufacturing costs caused by the use of expensive equipment and harsh preparation conditions in those preparation methods commonly used at present, and the preparation process is simple and highly controllable

Method used

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  • Medical beta-titanium alloy composite material with osteogenesis inducing activity and preparation method thereof
  • Medical beta-titanium alloy composite material with osteogenesis inducing activity and preparation method thereof
  • Medical beta-titanium alloy composite material with osteogenesis inducing activity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Melting of medical β titanium alloy

[0033] The method of combining d-electron theory and Mo equivalent is used to determine the composition content of titanium alloys. Pure titanium rods (purity 99.9%), Ti-70Nb alloy rods, Zr rods (purity 99.9%) and Mo powder (purity 99.9%) ) as the raw material, according to the mass ratio Ti:Nb:Zr:Mo=67:25:6:2, the sum of the mass percentages of the elements involved is 100%, and Ti-25Nb-6Zr-2Moβ is smelted and centrifugally cast in a vacuum suspension furnace titanium alloy.

[0034] (2) Surface pretreatment of medical β titanium alloy substrate

[0035] Heat the smelted Ti-25Nb-6Zr-2Mo medical β-titanium alloy to 1100°C for 30 minutes, then hot-roll it into rods with a diameter of 12mm, then cut the titanium alloy rods into 200mm pieces and put them in a vacuum annealing furnace under argon gas. Annealing treatment at 820°C for 40min in a protective atmosphere, and then cut the titanium alloy rod into a sample piece with a t...

Embodiment 2

[0048] (1) Melting of medical β titanium alloy

[0049]Using pure titanium rods (99.9% purity), Ti-70Nb alloy rods, Zr rods (99.9% purity) and Mo powder (99.9% purity) as raw materials, according to the mass ratio Ti:Nb:Zr:Mo=66:25 : 6: 3, where the sum of the mass percentages of the elements involved is 100%, and the Ti-25Nb-6Zr-3Moβ titanium alloy is formed by vacuum suspension furnace melting and centrifugal casting.

[0050] (2) Surface pretreatment of medical β titanium alloy substrate

[0051] Heat the smelted Ti-25Nb-6Zr-3Mo medical β-titanium alloy to 1100°C for 30 minutes, then hot-roll it into a rod with a diameter of 12mm, then cut the titanium alloy rod into 100mm pieces and put them in a vacuum annealing furnace under argon Annealing treatment at 820°C for 40min in a protective atmosphere, and then cut the titanium alloy rod into a sample piece with a thickness of 2mm. Mix 0.8% hydrofluoric acid and 4% nitric acid at a volume ratio of 1:5 to form a solution to c...

Embodiment 3

[0057] (1) Melting of medical β titanium alloy

[0058] Using pure titanium rods (99.9% purity), Ti-70Nb alloy rods, Zr rods (99.9% purity) and Mo powder (99.9% purity) as raw materials, according to the mass ratio Ti:Nb:Zr:Mo=65:25 :6:4, where the sum of the mass percentages of the elements involved is 100%, and the Ti-25Nb-6Zr-4Moβ titanium alloy is formed by vacuum suspension furnace melting and centrifugal casting.

[0059] (2) Surface pretreatment of medical β titanium alloy substrate

[0060] Heat the smelted Ti-25Nb-6Zr-4Mo medical β-titanium alloy to 1100°C for 30 minutes, then hot-roll it into rods with a diameter of 12mm, then cut the titanium alloy rods into 100mm pieces and put them in a vacuum annealing furnace under argon Annealing treatment at 820°C for 40min in a protective atmosphere, and then cut the titanium alloy rod into a sample piece with a thickness of 2mm. Mix 0.9% hydrofluoric acid and 5% nitric acid in a volume ratio of 1:5 to form a solution to ch...

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Abstract

The invention relates to a medical beta-titanium alloy composite material with osteogenesis inducting activity and a preparation method thereof. The material comprises a base material and a titanium oxide nano-tube array layer, which is generated in-situ and attached to the surface of the base material and contains BMP-2 cell growth factors. The base material is a medical beta-titanium alloy of the Ti-25Nb-6Zr-xMo family, wherein the x is between 2 and 5. The diameters of nano-tubes, which are generated in-situ on the alloy surface, are between 30 and 50 nm, the lengths of the nano-tubes are between 200 and 300 nm, and the nano-tubes are arranged in arrays and perpendicular to the surface of the titanium alloy. The medical beta-titanium alloy composite material has ultra-low elastic modulus and is capable of forming better interface mechanic matching with the bone tissue. So osteoblasts grow rapidly along the wall on the surface of medical beita-titanium alloy whose surface is loaded with titanium oxide nano-tube biological composite material containing BMP-2, and proliferate obviously. The composite material has a good effect on inducing osteoblasts to proliferate to form bone matrix and can be used to bone replacement or repairing.

Description

technical field [0001] The technical solution of the invention relates to the nanometerization and surface activation of the medical β-titanium alloy, in particular to the medical β-titanium alloy composite material with osteogenic activity and its preparation method. Background technique [0002] Titanium and its alloys have become the first choice for biomedical metal materials due to their excellent biocompatibility and mechanical adaptability, among which medical β titanium alloy has lower elastic modulus, better biocompatibility, wear resistance and corrosion resistance And formability, and no potential toxic elements exist, so it is more suitable for use as implant material. With the development of nanotechnology and nanofabrication technology, it has become one of the research hotspots to improve the biocompatibility and bioactivity of medical titanium alloy surface by nano-modification. As an implant material, the nano-biological layer on the surface of titanium all...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/06A61L27/54C25D11/26
Inventor 戚玉敏崔春翔马柏慧刘双进孙继兵赵立臣耿月娇
Owner HEBEI UNIV OF TECH
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