Preparation method of chemically crosslinked nanocomposite hydrogel

A nano-composite and chemical cross-linking technology, applied in the field of preparation of nano-composite hydrogels, can solve the problems of gel mechanical properties and swelling properties disappearing, and the network structure is easily destroyed, so as to achieve good network structure and performance, and raw material sources Broad, well-stabilized effect

Inactive Publication Date: 2010-10-20
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, all these nanocomposite hydrogels are formed based on physical bonding, and the network structure is easily destroyed under higher te

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 34g deionized water, 24g styrene, and 0.72g sodium lauryl sulfate are added to the equipment equipped with stirring device, reflux device and N 2 In the three-necked flask at the entrance, stir and pass N 2 After heating up to 75°C, 2ml of 3.6% potassium persulfate aqueous solution was added dropwise. After reacting for 1 hour, acetone with 0.48g of polymerizable photoinitiator 2-hydroxydimethylpropiophenone methacrylic acid ethylene glycol was added to the system. 6ml of solution was added within 6 hours. After that stop passing N 2 , the heating was stopped, the reaction was stopped, and the prepared microspheres were dialyzed in distilled water for 72 hours. Take 20 g of the reactive emulsion, add 6 g of acrylamide monomer during stirring, and illuminate for 5 minutes to prepare a chemically cross-linked nanocomposite hydrogel.

Embodiment 2

[0025] 55g deionized water, 3g methyl acrylate, 0.003g sodium dodecylbenzene sulfonate were added to the equipment equipped with stirring device, reflux device and N 2 In the three-necked flask at the entrance, stir and pass N 2 After heating up to 80°C, add 2ml of 0.15% sodium persulfate aqueous solution dropwise, and after reacting for 1 hour, add acetone with 0.3g of polymerizable photoinitiator 2-hydroxydimethylpropiophenone methacrylate glycol in the system 4ml of solution was added within 6 hours. After that stop passing N 2 , the heating was stopped, the reaction was stopped, and the prepared microspheres were dialyzed in distilled water for 72 hours. Take 20 g of reactive emulsion, add 20 g of acrylic acid monomer during stirring, and light for 5 minutes to prepare chemically cross-linked nanocomposite hydrogel.

Embodiment 3

[0027] 45g deionized water, 12g ethyl acrylate, 0.36g hexadecyltrimethylammonium chloride were added to the equipment equipped with stirring device, reflux device and N 2 In the three-necked flask at the entrance, stir and pass N 2 After heating up to 85°C, 3ml of 0.8% potassium persulfate aqueous solution was added dropwise, and after 1 hour of reaction, acetone with 0.24g of reactive photoinitiator 2-hydroxydimethylpropiophenone methacrylate glycol was added to the system. 5ml of the solution was added within 6 hours. After that stop passing N 2 , the heating was stopped, the reaction was stopped, and the prepared microspheres were dialyzed in distilled water for 72 hours. Take 20 g of the reactive emulsion, add 6 g of isopropylacrylamide monomer during stirring, and illuminate for 5 minutes to prepare a chemically cross-linked nanocomposite hydrogel.

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Abstract

The invention relates to a preparation method of a chemically crosslinked nanocomposite hydrogel, which comprises the following steps: (1) adding water, hydrophobic monomers and a surfactant into a container, raising the temperature to a certain temperature, adding a water-soluble initiator, carrying out reaction for 1h-2h, adding acetone solution of a polymerizable photoinitiator into a system, completing the adding within 6h, stopping heating, obtaining nano-microspheres with photo-initiation activity and carrying out dialysis on the prepared microspheres in distillated water for 72h; and (2) adding emulsion of the microspheres with the photo-initiation activity in the concentration of 5%-40% after the dialysis of the step (1) into water-soluble monomers for light radiation. The preparation method has the advantages of simpleness, wide sources of raw materials, high polymerization efficiency and fast polymerization speed, and is applicable to industrial production; and the obtained nanocomposite hydrogel has excellent mechanical properties and good stability.

Description

technical field [0001] The invention belongs to the field of preparation of nanocomposite hydrogel, in particular to a preparation method of chemically crosslinked nanocomposite hydrogel. Background technique [0002] Polymer hydrogel is a special soft and wet material. It is a system composed of cross-linked hydrophilic polymers with a three-dimensional network structure and a solvent. It can swell in water but not dissolve, and can maintain a certain shape. The bonding of polymer hydrogels is diverse, including chemical covalent bonds, physical weak bonds (such as hydrogen bonds, electrostatic interactions, van der Waals forces, etc.), and interpenetration and entanglement through chain segments. and so on to form a cross-linked structure. [0003] Synthetic hydrogel materials are more similar to living tissue in terms of physical properties than any other synthetic materials, so they are expected to be widely used in biomedical and other fields. However, due to the unev...

Claims

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Application Information

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IPC IPC(8): C08F285/00C08F257/02C08F2/48C08J3/075
Inventor 武永涛朱美芳夏梦阁张燕范青青
Owner DONGHUA UNIV
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