Preparation method of chemically crosslinked nanocomposite hydrogel

Abstract

The invention relates to a preparation method of a chemically crosslinked nanocomposite hydrogel, which comprises the following steps: (1) adding water, hydrophobic monomers and a surfactant into a container, raising the temperature to a certain temperature, adding a water-soluble initiator, carrying out reaction for 1h-2h, adding acetone solution of a polymerizable photoinitiator into a system, completing the adding within 6h, stopping heating, obtaining nano-microspheres with photo-initiation activity and carrying out dialysis on the prepared microspheres in distillated water for 72h; and (2) adding emulsion of the microspheres with the photo-initiation activity in the concentration of 5%-40% after the dialysis of the step (1) into water-soluble monomers for light radiation. The preparation method has the advantages of simpleness, wide sources of raw materials, high polymerization efficiency and fast polymerization speed, and is applicable to industrial production; and the obtained nanocomposite hydrogel has excellent mechanical properties and good stability.

Description

technical field

[0001] The invention belongs to the field of preparation of nanocomposite hydrogel, in particular to a preparation method of chemically crosslinked nanocomposite hydrogel. Background technique

[0002] Polymer hydrogel is a special soft and wet material. It is a system composed of cross-linked hydrophilic polymers with a three-dimensional network structure and a solvent. It can swell in water but not dissolve, and can maintain a certain shape. The bonding of polymer hydrogels is diverse, including chemical covalent bonds, physical weak bonds (such as hydrogen bonds, electrostatic interactions, van der Waals forces, etc.), and interpenetration and entanglement through chain segments. and so on to form a cross-linked structure.

[0003] Synthetic hydrogel materials are more similar to living tissue in terms of physical properties than any other synthetic materials, so they are expected to be widely used in biomedical and other fields. However, due to the unev...