Vaccine adjuvant

An adjuvant and vaccine technology, applied in the field of immunology, to achieve the effects of efficiently stimulating the body's immune response, excellent sensitization and safety, and simple preparation process

Inactive Publication Date: 2009-06-03
INST OF MEDICAL BIOLOGY CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
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  • Claims
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Problems solved by technology

[0005] In order to solve the defects of existing vaccine adjuvants in aspects such as safety, the present inventi

Method used

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Embodiment 1

[0018] 1. Preparation and qualitative and quantitative analysis of zinc hydroxide

[0019] A. Preparation of zinc hydroxide adjuvant: slowly add ammonia solution with a concentration of 7 mol / L to the zinc acetate solution with a concentration of 0.6 mol / L under continuous stirring at 60°C until the pH value reaches 5.5 and When the stability is maintained, stop adding, and then continue heating for 1 hour, a white paste is formed on the container wall, transfer the white paste into a centrifuge tube, centrifuge at 14000rpm for 1 minute, suck out the supernatant, and use an appropriate amount of the remaining white precipitate After washing with pure water three times, it was suspended and collected in pure water to obtain a zinc hydroxide suspension, which was autoclaved at 121° C. for 20 minutes and set aside. The reaction equation of this chemical reaction is as follows:

[0020] (CH3COO) 2 Zn+2NH 3 ·H 2 O→Zn(OH) 2 +2CH 3 COONH 4

[0021] B. Qualitative and quantita...

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Abstract

The invention relates to a vaccine adjuvant, in particular to the application of compound zinc hydroxide in the aspect of vaccine adjuvant preparations and further the application in the aspect of VAOTA adjuvant preparation.s The zinc hydroxide has a chemical formula of Zn(OH)2 and a chemical formula weight of 99.4046 Dalton. The zinc hydroxide working as an adjuvant is jointly applied with vaccine, so as to effectively strengthen body fluid immune response of the vaccine, and the immune strength effect is superior to that of aluminum adjuvant. In addition, according to the animal experiment result, both the sensitization and the safety of zinc hydroxide are superior to aluminum adjuvant.

Description

technical field [0001] The present invention relates to a kind of vaccine adjuvant, especially relates to chemical formula is Zn (OH) 2 The invention relates to a zinc hydroxide compound with a chemical formula of 99.4046 daltons, and its application in the preparation of vaccine adjuvants belongs to the field of immunology. Background technique [0002] Zinc is an essential trace element for all organisms, especially the growth and development of the human body is inseparable from zinc. High or low levels of zinc in the body can have important effects on the nervous, reproductive and immune systems. The relationship between zinc and the body's immune system is relatively complex, mainly reflected in the following four aspects: ①The daily intake and absorption of zinc depends on the composition of food, individual age and health status; ②As more than 300 kinds of zinc Cofactors of biologically active enzymes can indirectly affect the immune system; ③Zinc can have a direct ...

Claims

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Application Information

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IPC IPC(8): A61K39/39
Inventor 胡云章胡凝珠王海漩乌美妮
Owner INST OF MEDICAL BIOLOGY CHINESE ACAD OF MEDICAL SCI
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