Method for producing medicine using silkworm expressed numan epidermal growth factor

A technology of epidermal growth factor and medicine, applied in the field of expressing human epidermal growth factor to produce medicine, can solve the problem of high production cost
CN1405310AInactive Publication Date: 2003-03-26正源堂(天津)生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
正源堂(天津)生物科技有限公司
Publication Date
2003-03-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technique field of producing multi-peptide drugs by gene engineering. It clones human EGF gene into the silkworm bacilliform virus (Bombyx mori Nuclear polyhedrosis Virus) transferring carrier pBacPAK8 and makes them carry through homologous reformation in the silkworm cells to obtain the reformed virus BmBacEGF with human-coat growing gene. Use the reformed virus to to inocualte the silkworm grub and chrysalis by acupuncture in order to make the human-coat growing gene efficient expressed. Then make the grub and chrysalis into oral drugs which has remarkable action on the digestible ulcer by examination on animal.
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Description

technical field

[0001] The invention relates to a method for producing medicine by using silkworms to express human epidermal growth factor (Epidermal growth Factor, EGF). Background technique

[0002] Epidermal growth factor (EGF) was accidentally discovered by Cohen in 1959 when studying nerve growth factor (NGF), and was isolated from mouse submandibular gland in 1962. In vivo and in vitro experiments have proved that it has the function of promoting proliferation of epithelial cells derived from various tissues. Human epidermal growth factor was first purified from human urine by Gregory et al. in 1975. Through research, it was found that it has the same biological activity as mouse EGF . The most potential use of EGF is in clinical application. EGF has the function of promoting epithelial regeneration, and can be used to promote the healing of surgical wounds and other wounds, such as skin grafts, skin abrasions, burns, erosion, etc.; to promote corneal epithelial rege...

Claims

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