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Biocompatibility modified starch sponges

A biocompatible, modified starch technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of clinical application limitations, slow absorption by the human body, etc., and achieve non-toxic side effects, good biocompatibility, and convenient use Effect

Active Publication Date: 2009-06-17
BEIJING UNIVERSAL LIKANG TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main body of this hemostatic dressing is oxidized cellulose, which is slowly absorbed by the human body, so the clinical application is limited.

Method used

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  • Biocompatibility modified starch sponges
  • Biocompatibility modified starch sponges
  • Biocompatibility modified starch sponges

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Put 2g of pregelatinized hydroxypropyl distarch phosphate 51# into 30ml of water, stir continuously to make the starch granules fully swell and disperse in the water to form a uniform suspension, add a few drops of glycerin as a forming agent, and then pour it into the container , pre-cooled at -40°C for 22 hours, then placed in a freeze dryer, and freeze-dried at -40°C with a vacuum of less than 20 Pa for 20 hours to obtain the hemostatic sponge A.

[0090] Take 3g of 51# hemostatic sponge A, add 30ml of water, and form a coagulated water mixture viscous glue after absorbing water, and its viscous work index is 76.42g·sec.

[0091] The test method of the viscous work index of the present invention adopts a physical property analyzer (texture analyzer); the test conditions are: under normal temperature, the speed before the test: 0.5mm / sec; the test speed: 10mm / sec.

[0092] The viscous work index means that the probe will be subjected to the cohesive force of the sampl...

Embodiment 2

[0094] Put 1g of pregelatinized hydroxypropyl distarch phosphate 51# into 30ml of water, stir constantly to make the starch granules fully swell and disperse in the water to form a uniform suspension, then pour it into a container and pre-cool at -40°C After 22 hours, put it into a freeze dryer, freeze-dry for 20 hours at -50°C and a vacuum of less than 20 Pa, and obtain the hemostatic sponge B.

[0095] see figure 1 Scanning electron micrograph of the section of the hemostatic sponge A, figure 2 As shown in the scanning electron micrograph of the section of the hemostatic sponge B, adding a plasticizer during the preparation process reduces the pore size of the sponge pores and increases the density and specific surface area.

Embodiment 3

[0097] Put 2g of carboxymethyl starch 66# into 30ml of water, stir continuously to make the starch granules fully swell and disperse in water to form a uniform suspension, then pour it into a container, pre-cool at -40°C for 22 hours, and then put it in In a freeze dryer, freeze-dry for 20 hours at -50°C and a vacuum of less than 20 Pa to obtain a hemostatic sponge C.

[0098] Take 1.5g of 66# hemostatic sponge C, add 30ml of water, and form a coagulated water mixture viscous glue after absorbing water, and its viscous work index is 162.68g·sec.

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Abstract

The invention relates to biocompatible modified starch sponge and use of the biocompatible modified starch sponge as a hemostatic material, an anti-adhesion material, a material for promoting tissue healing, a surgical sealant or a wound tissue adhesive. Modified starch is one or a combination of more than one among pre-gelatinized starch, acid modified starch, dextrin, oxidized starch, esterified starch, etherified starch, crosslinked starch, grafted starch and composite modified starch. The sponge is prepared by vacuum freeze drying of the modified starch and other biocompatible hemostatic material, coagulant, plasticizer and so on. The biocompatible modified starch sponge has the advantages that the biocompatible modified starch sponge has flexible form and good biocompatibility, can be directly acted on bloody wound surfaces, avoids the conditions of hypersusceptibility, infection and difficult healing of wounds caused by adoption of hemostatic materials such as animal source / human source collagens, obviously improves the water absorption speed, has larger viscosity, forms a zymoplastic mixture which has good adhesion, calks broken tissues and blood vessels, and is used for hemostasis of active hemorrhage.

Description

technical field [0001] The invention relates to a biocompatible modified starch sponge, which can be directly used on bloody wounds of humans and mammals. The invention also relates to the application of the sponge as hemostatic material, biocompatible anti-adhesion material, tissue healing promotion material, absorbable surgical sealant, wound tissue glue, and the sponge product thereof. Background technique [0002] Surgical operations and trauma will form bloody wounds, during which a large amount of blood will be lost, and it is necessary to use hemostatic means in time. Applying biocompatible absorbable hemostatic materials on bleeding wounds is a common means of hemostasis. There is an urgent need for surgical hemostasis, trauma, and emergency hemostasis. This shows the importance of providing a safe, effective, easy-to-use and low-cost hemostatic material to the market. [0003] The commonly used surgical absorbable hemostatic materials include the following: [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28
CPCA61L26/0023A61L15/28A61L26/0085A61L15/58
Inventor 纪欣刑程史学深陈建萍
Owner BEIJING UNIVERSAL LIKANG TECH CO LTD
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