Sterile polymerized covering dressing for wound surface
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A wound repair and amorphous technology, applied in bandages, absorbent pads, medical science and other directions, can solve the problems of cumbersome preparation process, unsuitable for industrial production, etc., and achieve the effect of avoiding cross infection, reducing temperature, and avoiding air permeability.
Active Publication Date: 2013-05-08
JIANGSU HUAYI CELL & TISSUE ENG CO LTD
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Embodiment 1
[0117] Chitosan 10g, polyvinyl alcohol 30g, alginate 5g, isomaltooligosaccharide 10g, Carbopol 940 2g, gelatin 2g, carboxymethylcellulose sodium 5g, glycerin 10g, menthol 0.01g, condensed tannins 15g. Transdermal absorption accelerator synthetic borneol 5g, appearance regulator theaflavin 0.02g. For the preparation method, refer to the steps and methods for the preparation of the semi-solid amorphous dressing.
[0118] Animal model experiment results:
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[0120] Clinical Trial Results:
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[0122] Clinical trial conclusion: There were no abnormal changes in the two routine tests, and no severe allergic adverse reactions in the whole body or treatment site. The patient has strong acceptability of dressing change, and the pain is significantly reduced. The acceptability of doctors and patients has been verified in this clinical trial. Medical moist burn wound dressings can accelerate wound healing, relieve pain, and increase the acceptability of patients' ...
Embodiment 2
[0124] Chitosan 15g, polyvinyl alcohol 40g, high viscosity alginate 6g, isomaltooligosaccharide 12g, Carbopol 9403.5g, gelatin 3g, carboxymethylcellulose sodium 7g, glycerin 15g, menthol 0.08g, condensation Tannin 30g. The appearance regulator copper chlorophyllin sodium salt 0.02g. For the preparation method, refer to the steps and methods for the preparation of the semi-solid amorphous dressing.
[0125] Animal model experiment results:
[0126]
Embodiment 3
[0128] Chitosan 18g, polyvinyl alcohol 50g, alginate 14g, isomaltooligosaccharide 14g, Carbopol 940 4.5g, gelatin 4.5g, sodium carboxymethylcellulose 8g, glycerin 18g, menthol 0.1g. Transdermal absorption enhancer propylene glycol 10g, appearance regulator theaflavin 0.02g. For the preparation method, refer to the steps and methods for the preparation of the semi-solid amorphous dressing.
[0129] Animal model experiment results:
[0130]
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[0132] Clinical Trial Results:
[0133]
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Abstract
The invention provides a sterile polymerized covering for a wound surface-medical wet dressing for a burn wound, a preparation method of the dressing, and application. The dressing comprises the following components: 10 to 30g of chitosan, 30 to 80g of polyving akohol, 5 to 10g of alginate, 5 to 15g of isomaltose hypgather, 2 to 6g of carbomer 940, 2 to 5g of gelatin, 5 to 10g of sodium carboxymethylcellulose, 10 to 30g of glycerol, and 0.01 to 0.2g of menthol; 15 to 60g of condensed tannin which is remarkable in treatment can be selectively added; and a skin penetration enhancer or an appearance conditioning agent also can be selectively added. The dressing can be prepared into an irregular dressing in order to be suitable for the wound surfaces in irregular and special positions and also can be prepared into a solid plate-shaped dressing which can be shorn at random. According to the sterile polymerized covering dressing for the wound surface, the freezing and thawing technology and the irradiating technology are combined and cross-linked to realize the preparation, and the defects of the prior art can be overcome. The dressing is high in biocompatibility, free from toxicity and sensitization and high in mechanical strength and comfort level, is out of adhering during the process of being replaced after being attached for a long time, and is a nonantigenic protective barrier which has the effect of resisting and inhibiting bacteria.
Description
technical field [0001] The invention belongs to the medical technical field of burn wound protection, in particular to the medical technical field of burn wound protection, in particular to a medical moist burn wound dressing. Background technique [0002] The skin is an important organ of the human body, composed of epidermis, dermis and subcutaneous tissue. The basic functions of the skin have five aspects: protection function, temperature regulation function, sensory function, perspiration function and absorption function. At the same time, it has important physical, chemical and biological barrier functions. Burns are the most common skin wounds in peacetime and wartime, and the severity of burns is determined by the etiology, size and depth of the burns. Various damages caused by skin trauma, such as: increased metabolism, decreased body temperature, excessive loss of water, blood and protein, and disorders of the endocrine and immune systems are all related to the los...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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