Coating for use with medical devices and method of making same
a technology of silicone and medical devices, applied in the field of silicone based medical devices, can solve the problems of system offering poor adhesion to silicone medical devices, additional manufacturing process steps, and inability to meet the requirements of patients, and achieve the effect of enhancing adhesion and facilitating drug delivery
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example 1
[0024] A drug delivery coating for silicone medical devices is prepared by blending at room temperature the following components in three separate containers. In a first container, THF, Pellethane® and an emulsifier are mixed for at least 2-3 hours until the Pellethane® is fully dissolved forming a first solution. In a second container, NMP and norfloxacin are mixed for approximately 20 minutes forming a second solution. In a third container, tolnaftate is mixed for approximately 10 minutes with THF until the tolnaftate is dissolved forming a third solution. The second solution is added to the first solution and mixed for approximately 5-10 minutes. The third solution is added to the combination of the first and second solutions and the combined solutions are mixed for approximately 15 minutes. Prior to coating the medical device, the RTV / Silane is added to the combined solutions and mixed for approximately one hour.
THF29.75 gFirst ContainerUrethane 3 gEmulsifier 0.25 gNMP 30 g...
example 2
[0025] A drug delivery coating for silicone medical devices is prepared by blending at room temperature the following components in three separate containers. In a first container, THF, Pellethane® and an emulsifier are mixed for at least 2-3 hours until the Pellethane® is fully dissolved forming a first solution. In a second container, NMP and norfloxacin are mixed for approximately 20 minutes forming a second solution. In a third container, clotrimazole is mixed for approximately 10 minutes with THF until the clotrimazole is dissolved forming a third solution. The second solution is added to the first solution and mixed for approximately 5-10 minutes. The third solution is added to the combination of the first and second solutions and the combined solutions are mixed for approximately 15 minutes. Prior to coating the medical device, the RTV / Silane is added to the combined solutions and mixed for approximately one hour.
THF29.75 gFirst ContainerUrethane 3 gEmulsifier 0.25 gNMP ...
example 3
[0026] A drug delivery coating for silicone medical devices is prepared by blending at room temperature the following components in three separate containers. In a first container, THF, Pellethane® and an emulsifier are mixed for at least 2-3 hours until the Pellethane® is fully dissolved forming a first solution. In a second container, NMP and norfloxacin are mixed for approximately 20 minutes forming a second solution. In a third container, RTV / Silane is mixed for approximately one hour with THF until the RTV / Silane is dissolved forming a third solution. The second solution is added to the first solution and mixed for approximately 5-10 minutes. The third solution is added to the combination of the first and second solutions and the combined solutions are mixed for approximately one hour.
THF29.75 gFirst ContainerUrethane 3 gEmulsifier 0.25 gNMP 25 gSecond ContainerNorfloxacin 1 gTHF 40 gThird ContainerRTV / Silane 1 g
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