32 results about "Vascular reactivity" patented technology

Disclosed are methods, compositions, and cells useful for increasing insulin sensitivity, as well as lack of insulin production in a host in need thereof. One aspect of the invention discloses methods of increasing skeletal muscle perfusion through administration of cells capable of directly and/or indirectly stimulatory of angiogenesis and/or vascular responsiveness. Another aspect provides means of increasing sensitivity to insulin through administration of a cell composition capable of integrating into host insulin responsive tissue and upregulating responsiveness either through mobilization of host cells capable of responding to insulin, mobilization of host cells capable of endowing insulin responsiveness on other host cells, exogenously administered cells taking the role of insulin responsiveness, or exogenously administered cells endowing insulin responsiveness on other host cells. Another aspect comprises modifying said host to allow for concurrent insulin sensitization and upregulated production of insulin.

Methods and apparatus are provided for identifying and minimizing neurovascular contributions to determinations of endothelial function, including by digital temperature monitoring such that an accurate status of vascular reactivity can be obtained. Methods are also provided for identifying individuals having increased sympathetic nervous system activity impacting peripheral vascular function as well as for determining a status of diabetic foot.

A monitoring device may include logic to receive arterial blood pressure data associated with a patient and receive tissue hemoglobin data associated with the patient. The logic may also calculate a linear correlation between the arterial blood pressure data and the tissue hemoglobin data. The correlation may be used to assess vascular reactivity.

The invention discloses a Chinese medicinal preparation for treating various dermatoses, which is prepared from 21 Chinese medicaments such as cortex dictamni, erythrina indica lam and the like capable of promoting blood circulation by removing blood stasis and promoting circulation of qi and to relieve pain. The Chinese medicinal preparation has a unique formulation and precise and appropriate compatibility, has the effects of dispelling wind to nourish blood, removing dampness to relieve itching and cooling blood to remove toxic materials, has no bad adverse effects for clinical application, has a wide treatment range, overcomes the difficulties in grouping treatment of the dermatoses by using Chinese medicines and western medicines, and has significant curative effect of treating various dermatoses such as psoriasis, neurodermatitis, eczema, hives and acne which mainly causes epidermal hyperplasia, skin sichenification, inflammation of cuticula or a derma shallow layer, and vascular reactive and obstructive folliculus pili steatadenitis. After the prescription is taken for 7 days, itching disappears, lesion parts such as papula and maculopapule are gradually fade away, erythema and wheal disappears, exsudation is reduced, and squamae become thinner or fall off; after 14 to 21 days, the papula and the maculopapule disappears, the squamae are reduced, the sichenification disappears to achieve clinical healing; and after 28 to 35 days, skin lesions return to normal and are difficult to have a relapse.

Systems and methods are disclosed for using vessel reactivity to guide diagnosis or treatment for cardiovascular disease. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; determining, by measurement or estimation, a first vessel size at one or more locations of a vessel of the patient-specific vascular model at a first physiological state; determining a second vessel size at the one or more locations of the vessel of the patient-specific vascular model at a second physiological state using a simulation or learned information; comparing the first vessel size to the corresponding second vessel size; and estimating a characteristic of the vessel of the patient-specific vascular model based on the comparison.

The invention provides methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. The invention also provides methods for increasing sensitivity and specificity of BOLD MRI.

The present invention is generally directed to methods and materials for determining the genotype of a patient to predict the patient's vasoreactivity. More particularly, the present invention is directed to a method of determining the vasoreactivity of a subject, comprising: obtaining from a subject a sample comprising a nucleic acid sequence of the BMPR2 gene or amino acid sequence of the BMPR2 gene; determining the presence or absence of a non-synonymous mutation in the BMPR2 nucleic acid or amino acid sequence, and correlating the presence of a non-synonymous mutation with non-vasoreactivity or the absence of a non-synonymous mutation with vasoreactivity.

Described here are systems and methods for estimating a quantitative measure of cerebrovascular reactivity (“CVR”) from data acquired using resting-state functional magnetic resonance imaging (“fMRI”).

Featured are methods for non-invasive assessment of vascular reactivity. The methods of the invention use phase contrast magnetic resonance imaging angiography and use the image data thereby acquired to measure shear rate, radius of the vasculature and flow through the vasculature. According to one aspect, such acquisition of image data occurs before and during, an arterial occlusion and according to another aspect such acquisition of image data occurs before during and after arterial occlusion. The disclosed methods of the invention allow for reproducible, non-invasive diagnosis of early stage indicators of atherosclerosis.

A method for digital thermal monitoring assessment of vascular function comprising a temporary arterial occlusion using a pneumatic cuff positioned on a subject's upper limb, monitoring skin temperature at the fingertip of the occluded limb for a period of time before, during, and after the occlusion, calculating a Zero Reactivity Curve based on variables including start temperature, room temperature, and the slope of temperature decline during the occlusion, and assessing vascular function based on comparing the Zero Reactivity Curve and the observed temperature rebound after the occlusion is removed. A vascular reactivity monitoring apparatus for measuring skin surface temperature comprising an inflatable cuff for placement around a subject's limb, a digital thermal measuring device and photoplethysmography measuring device for placement on a finger of the subject's limb wearing the cuff and a second digital monitoring device and photoplethysmography measuring device for placement on a finger of the subject's contralateral limb.

The invention provides methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO₂ to a subject to reach a predetermined PaCO₂ in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. The invention also provides methods for increasing sensitivity and specificity of BOLD MRI.

The invention relates to a skin classification method, a cosmetics recommendation method and a skin classification card. According to the skin classification method, skin of users is classified on the basis of erythema initial values and blood vessel reactivity of the users. The method includes the steps that the erythema initial values and the blood vessel reactivity of the users are measured; and according to the measured erythema initial values and the value of the measured blood vessel reactivity, which of four pre-classified skin types the skin belongs to is determined, wherein the four classified skin types are classified on the basis of correlation between the erythema initial values, the measured blood vessel reactivity values and skin features of multiple testees.

Circulating levels of catestatin (Cts: human chromogranin A352-372) decrease in the plasma of patients with essential hypertension. Genetic ablation of the chromogranin A (Chga) gene in mice increases blood pressure and pre-treatment of Chga-null mice with Cts prevents blood pressure elevation, indicating a direct role of Cts in preventing hypertension. This notable vasoreactivity prompted us to test the direct cardiovascular effects and mechanisms of action of wild-type Cts (WT-Cts) and naturally occurring human variants (G364S-Cts and P370L-Cts) on myocardial and coronary functions. The cardio-inhibitory influence exerted on basal mechanical performance and the counter-regulatory action against beta-adrenergic and ET-1 stimulations, point to Cts as a novel cardiac modulator, able to protect the heart against excessive sympathochromaffin over-activation, e.g. hypertensive cardiomyopathy.

The present disclosure relates to a cold and hot thermal treatment device. Hot heat and cold heat are produced by a heat production unit and are periodically and repeatedly transferred to a heat transfer unit that is in contact with a human body such that a temperature is not suddenly changed but is gradually changed. Thus, the device may be used when diagnosing whether vascular reactivity is maintained in corresponding hands and feet, may generate a temperature stimulus, and may repeatedly perform the temperature stimulus, thereby improving the vascular reactivity.

Featured are methods for non-invasive assessment of a vascular physiological parameter including but not limited to central arterial stiffness, vascular reactivity and/or local arterial stiffness. The methods of the invention use any one of a number of magnetic resonance imaging techniques known in the art to acquire image data so as to arrive at these vascular physiological parameters. Also such methods include locating the detector or imaging coil proximal to a single artery and external to the body/specimen. According to one aspect, the methodology determines the central arterial stiffness from image data acquired at the single arterial location. In another aspect, image data is acquired so that one or more of central arterial stiffness, vascular reactivity and/or local arterial stiffness can be determined from the acquired image data alone or in combination with other acquired data/information. The disclosed methods of the invention allow for reproducible, non-invasive diagnosis of early stage indicators of atherosclerosis.