7 results about "Vascular reactivity" patented technology

The invention discloses a combined evaluation method for in-vitro and in-vivo red fading and relieving effects of cosmetic raw materials, which comprises the following steps: in-vitro model evaluation: inducing a human immortalized umbilical vein endothelial cell model by adopting TNF-alpha, and detecting the secretion amount of a prostacyclin I2 factor to obtain a score of an in-vitro model; in-vivo model evaluation: adopting a chick embryo chorioallantoic membrane model, and obtaining a score of the in-vivo model according to the degree of vasoconstriction caused by the to-be-detected raw material sample acting on the chick embryo chorioallantoic membrane; and comprehensive evaluation: based on the score of the in-vitro model and the score of the in-vivo model, comprehensively evaluating the red fading and relieving efficacy of the raw material sample to be tested. According to the technical scheme, the defect that in the prior art, no cosmetic raw material soothing efficacy evaluation method for the vascular reactivity increasing mechanism exists is overcome, efficacy evaluation is more accurate, the method has the advantages of being comprehensive, short in test period, easy to operate, economical and convenient, and an effective reference basis is provided for screening and compounding schemes of red fading and soothing raw materials.

The invention discloses a cerebrovascular reactivity evaluation method for non-invasive calculation of a breath-holding index, and belongs to the field of hemodynamics numerical calculation and multi-scale modeling. The method comprises the following steps: constructing a one-dimensional (1D) arteriole hemodynamic model based on an allotactic scale law; constructing a main artery three-dimensional (3D) model, and coupling the main artery three-dimensional (3D) model with the arteriole one-dimensional model and the microcirculation zero-dimensional (0D) model to form a whole-brain 3D-1D-0D geometric multi-scale hemodynamic model; based on blood flow related data obtained in the experiment process, parameterization description is conducted on arteriole radius changes and microcirculation resistance changes; a breath holding index (BHI) is calculated by numerical solution of the geometric multi-scale model. According to the method, the non-invasive numerical calculation of the breath-holding index can be realized without directly implementing a breath-holding experiment or an external stimulation condition, and a stable and repeatable calculation means is provided for quantitative analysis and related engineering application of cerebrovascular hemodynamic behaviors.

A method for quantitative measurement of cerebral vascular reactivity (CVR) combines sequential gas delivery with ΔR2*-based perfusion analysis. Sequential gas delivery imposes a first stepwise reoxygenation after a first hypoxic condition and a second stepwise reoxygenation after a second hypoxic condition. In one mode, the second hypoxic condition produces greater vasodilation than the first; in another mode both hypoxia levels are minimal and an independent vasoactive stimulus, such as hypercapnia or acetazolamide, is applied between reoxygenations. MRI gradient-echo imaging records the ΔR2* time course in a target voxel during each reoxygenation. Sigmoid fitting yields perfusion metrics including relative cerebral blood flow, relative cerebral blood volume and mean transit time. Comparison of the metrics derived from the two reoxygenations provides a numerical CVR value that can be reproduced across sessions and subjects.

Embodiments of the present application disclose a kind of vascular reactivity evaluation method, device, electronic equipment and storage medium, wherein the method comprises: obtaining the first magnetic susceptibility weighted imaging of brain region of target object in free breathing state and the second magnetic susceptibility weighted imaging in breath-holding state;Determine the vascular distribution map of brain region;According to the first magnetic susceptibility weighted imaging and vascular distribution map, determine the first oxygen uptake fraction of target blood vessel in free breathing state;According to the second magnetic susceptibility weighted imaging and vascular distribution map, determine the second oxygen uptake fraction of target blood vessel in breath-holding state;According to the first oxygen uptake fraction and the second oxygen uptake fraction of target blood vessel, determine the evaluation index of vascular reactivity of target blood vessel, and evaluate the vascular reactivity of target blood vessel based on evaluation index.It can achieve the effect of simply, quickly and accurately evaluating vascular reactivity through oxygen uptake fraction in free breathing state and breath-holding state.

A method for the quantitative measurement of cerebral vascular reactivity (CVR) combines sequential gas delivery with ΔR2*-based perfusion analysis. The sequential gas delivery induces a first stepwise reoxygenation following an initial hypoxic state and a second stepwise reoxygenation following a second hypoxic state. In one mode, the second hypoxic state produces greater vasodilation than the first; in another mode, both hypoxia levels are minimal, and an independent vasoactive stimulus, such as hypercapnia or acetazolamide, is applied between reoxygenations. MRI gradient echo imaging records the ΔR2* time course in a target voxel during each reoxygenation. Sigmoid fitting provides perfusion metrics, including relative cerebral blood flow, relative cerebral blood volume, and mean transit time.The comparison of the measured values ​​derived from the two reoxygenations yields a numerical CVR value that is reproducible across sessions and subjects.

The application discloses a combined evaluation method for the in-vitro and in-vivo redness-reducing soothing effect of a cosmetic raw material, which comprises in-vitro model evaluation, adoption of a human immortalized umbilical vein endothelial cell model induced by TNF-alpha, acquisition of the in-vitro model score by detecting the secretion amount of prostacyclin I2 factor, in-vivo model evaluation, adoption of a chicken embryo chorioallantoic membrane model, acquisition of the in-vivo model score by the degree of blood vessel contraction caused by the action of the sample to be tested on the chicken embryo chorioallantoic membrane, and comprehensive evaluation of the redness-reducing soothing effect of the sample to be tested based on the in-vitro model score and the in-vivo model score. The technical scheme of the application makes up for the defect of the prior art that there is no cosmetic raw material soothing effect evaluation method for the mechanism of increased vascular reactivity, the effect evaluation is more accurate, and the method has the advantages of comprehensiveness, short test cycle, simple operation, economy and convenience, and provides an effective reference for the screening and compounding scheme of redness-reducing soothing raw materials.

To provide a technique for measuring cerebrovascular reactivity.SOLUTION: A method for quantitative measurement of cerebrovascular reactivity (CVR) combines sequential gas delivery with Δ R2 * - based perfusion analysis. The sequential gas delivery imposes a first staged reoxygenation 304 after a first hypoxia 302 and a second staged reoxygenation 310 after a second hypoxia 308. MRI gradient echo imaging records the Δ R2 * time course in the target voxel during each reoxygenation. The sigmoid fit yields perfusion indices including relative cerebral blood flow, relative cerebral blood volume, and mean transit time. Comparison of indices derived from two re-oxygenation sessions yields numerical CVR values that are reproducible between sessions and subjects.SELECTED DRAWING: Figure 3